INT69946

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Context Info
Confidence 0.04
First Reported 1997
Last Reported 1997
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.55
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MTAP) small molecule metabolic process (MTAP) nucleus (MTAP)
cellular nitrogen compound metabolic process (MTAP) cytoplasm (MTAP)
MTAP (Homo sapiens)
Pain Term Frequency Confidence Heat
adenocard 2 96.20 Very High Very High Very High
Paracetamol 2 75.00 Quite High
Disease Term Frequency Confidence Heat
Death 3 98.72 Very High Very High Very High
Liver Cancer 1 88.88 High High
Injury 2 75.00 Quite High
Hepatotoxicity 4 50.44 Quite High
Necrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Ca2+ chelator, ethylene glycol-bis (beta-aminoethyl ether) N',N',N', N'-tetraacetic acid (EGTA), blocked APAP-induced phosphorylase a activation and necrotic cell death, but failed to inhibit phosphorylase a activation by the adenosine 3',5'-cyclic monophosphate (cAMP) analogue, dibutyryl cAMP, indicating little or no contribution of the cAMP pathway to phosphorylase a stimulation during APAP-induced necrotic death.
Negative_regulation (blocked) of APAP Neg (failed) Positive_regulation (induced) of phosphorylase associated with adenocard and death
1) Confidence 0.04 Published 1997 Journal Hepatology Section Abstract Doc Link 9185764 Disease Relevance 0.55 Pain Relevance 0.16

General Comments

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