INT69947

Context Info Confidence 0.40 First Reported 1997 Last Reported 2010 Negated 0 Speculated 1 Reported most in Abstract Documents 5 Total Number 6 Disease Relevance 2.63 Pain Relevance 0.48

cytosol (MTAP) small molecule metabolic process (MTAP) nucleus (MTAP) cellular nitrogen compound metabolic process (MTAP) cytoplasm (MTAP)

Anatomy Link Frequency muscle tissue 2 blood vessels 1 MTAP (Homo sapiens)

Pain Link Frequency Relevance Heat adenocard 2 99.16 Pain 9 93.84 Paracetamol 2 75.00 halothane 2 5.00 peripheral neuropathy 2 5.00 Analgesic 1 5.00 antiepileptic Drug 1 5.00 backache 1 5.00 agonist 1 5.00 Glutamate 1 5.00

Disease Link Frequency Relevance Heat Death 7 99.68 Acute Renal Failure 4 99.08 Myoglobinuria 12 98.00 Infection 3 96.00 Disease 39 95.16 Cramps 5 94.16 Pain 5 93.84 Myalgia 5 88.76 Liver Cancer 1 85.40 Injury 2 79.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Biochemical study showed a partial defect in phosphorylase activity.

Spec (partial) Negative_regulation (defect) of phosphorylase

1) Confidence 0.40 Published 2003 Journal Rev. Neurol. (Paris) Section Abstract Doc Link 12910079 Disease Relevance 0.16 Pain Relevance 0.09

Three of them showed reduced phosphorylase activity in biopsied muscle tissue.

Negative_regulation (reduced) of phosphorylase in muscle tissue

2) Confidence 0.29 Published 2001 Journal An Med Interna Section Abstract Doc Link 11594178 Disease Relevance 0.90 Pain Relevance 0.09

The diagnosis is established by documentation of elevated glycogen content and reduced phosphorylase activity in biopsied muscle tissue.

Negative_regulation (reduced) of phosphorylase in muscle tissue

3) Confidence 0.29 Published 2001 Journal An Med Interna Section Abstract Doc Link 11594178 Disease Relevance 0.84 Pain Relevance 0.09

CONCLUSION: Flavonoids suppress tyrosine phosphorylase in a dose-dependent manner, and may have pharmacoceutical applications.

Negative_regulation (suppress) of phosphorylase

4) Confidence 0.05 Published 2002 Journal Clin. Chim. Acta Section Body Doc Link 11750278 Disease Relevance 0 Pain Relevance 0

The Ca2+ chelator, ethylene glycol-bis (beta-aminoethyl ether) N',N',N', N'-tetraacetic acid (EGTA), blocked APAP-induced phosphorylase a activation and necrotic cell death, but failed to inhibit phosphorylase a activation by the adenosine 3',5'-cyclic monophosphate (cAMP) analogue, dibutyryl cAMP, indicating little or no contribution of the cAMP pathway to phosphorylase a stimulation during APAP-induced necrotic death.

Negative_regulation (inhibit) of phosphorylase associated with adenocard and death

5) Confidence 0.04 Published 1997 Journal Hepatology Section Abstract Doc Link 9185764 Disease Relevance 0.50 Pain Relevance 0.16

Staining for phosphorylase is negative in muscle fibres whereas smooth muscle of blood vessels stains normally.Biochemically, reduced activity of phosphorylase may be found by enzymatic assays.

Negative_regulation (reduced) of phosphorylase in blood vessels

6) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2877206 Disease Relevance 0.23 Pain Relevance 0.05

General Comments

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