INT69947

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Context Info
Confidence 0.40
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 2.63
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MTAP) small molecule metabolic process (MTAP) nucleus (MTAP)
cellular nitrogen compound metabolic process (MTAP) cytoplasm (MTAP)
Anatomy Link Frequency
muscle tissue 2
blood vessels 1
MTAP (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 2 99.16 Very High Very High Very High
Pain 9 93.84 High High
Paracetamol 2 75.00 Quite High
halothane 2 5.00 Very Low Very Low Very Low
peripheral neuropathy 2 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
antiepileptic Drug 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 7 99.68 Very High Very High Very High
Acute Renal Failure 4 99.08 Very High Very High Very High
Myoglobinuria 12 98.00 Very High Very High Very High
Infection 3 96.00 Very High Very High Very High
Disease 39 95.16 Very High Very High Very High
Cramps 5 94.16 High High
Pain 5 93.84 High High
Myalgia 5 88.76 High High
Liver Cancer 1 85.40 High High
Injury 2 79.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Biochemical study showed a partial defect in phosphorylase activity.
Spec (partial) Negative_regulation (defect) of phosphorylase
1) Confidence 0.40 Published 2003 Journal Rev. Neurol. (Paris) Section Abstract Doc Link 12910079 Disease Relevance 0.16 Pain Relevance 0.09
Three of them showed reduced phosphorylase activity in biopsied muscle tissue.
Negative_regulation (reduced) of phosphorylase in muscle tissue
2) Confidence 0.29 Published 2001 Journal An Med Interna Section Abstract Doc Link 11594178 Disease Relevance 0.90 Pain Relevance 0.09
The diagnosis is established by documentation of elevated glycogen content and reduced phosphorylase activity in biopsied muscle tissue.
Negative_regulation (reduced) of phosphorylase in muscle tissue
3) Confidence 0.29 Published 2001 Journal An Med Interna Section Abstract Doc Link 11594178 Disease Relevance 0.84 Pain Relevance 0.09
CONCLUSION: Flavonoids suppress tyrosine phosphorylase in a dose-dependent manner, and may have pharmacoceutical applications.


Negative_regulation (suppress) of phosphorylase
4) Confidence 0.05 Published 2002 Journal Clin. Chim. Acta Section Body Doc Link 11750278 Disease Relevance 0 Pain Relevance 0
The Ca2+ chelator, ethylene glycol-bis (beta-aminoethyl ether) N',N',N', N'-tetraacetic acid (EGTA), blocked APAP-induced phosphorylase a activation and necrotic cell death, but failed to inhibit phosphorylase a activation by the adenosine 3',5'-cyclic monophosphate (cAMP) analogue, dibutyryl cAMP, indicating little or no contribution of the cAMP pathway to phosphorylase a stimulation during APAP-induced necrotic death.
Negative_regulation (inhibit) of phosphorylase associated with adenocard and death
5) Confidence 0.04 Published 1997 Journal Hepatology Section Abstract Doc Link 9185764 Disease Relevance 0.50 Pain Relevance 0.16
Staining for phosphorylase is negative in muscle fibres whereas smooth muscle of blood vessels stains normally.Biochemically, reduced activity of phosphorylase may be found by enzymatic assays.
Negative_regulation (reduced) of phosphorylase in blood vessels
6) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2877206 Disease Relevance 0.23 Pain Relevance 0.05

General Comments

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