INT6996

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Context Info
Confidence 0.70
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 2.22
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Tfrc) peptidase activity (Tfrc) mitochondrion (Tfrc)
aging (Tfrc) extracellular region (Tfrc) cytoplasmic membrane-bounded vesicle (Tfrc)
Anatomy Link Frequency
plasma 1
spinal 1
livers 1
Tfrc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 1 100.00 Very High Very High Very High
Morphine 1 99.72 Very High Very High Very High
depression 5 99.60 Very High Very High Very High
cytokine 42 98.60 Very High Very High Very High
withdrawal 3 96.12 Very High Very High Very High
Paracetamol 1 96.08 Very High Very High Very High
Enkephalin 2 75.00 Quite High
Opioid 1 75.00 Quite High
aspirin 1 67.92 Quite High
fluoxetine 1 66.76 Quite High
Disease Link Frequency Relevance Heat
Infection 1 100.00 Very High Very High Very High
Hypersplenism 1 99.84 Very High Very High Very High
Depression 5 99.60 Very High Very High Very High
Disease 9 90.84 High High
Injury 18 90.64 High High
Sickle Cell Anemia 8 90.52 High High
Abscess 6 77.08 Quite High
Hepatotoxicity 3 72.00 Quite High
Burns 3 65.04 Quite High
Hepatocellular Cancer 3 61.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Experiment 2 demonstrated that the dose-response curve relating systemic morphine treatment to increases in TFR thresholds was shifted to the right in chronic spinal rats.
Positive_regulation (increases) of TFR in spinal associated with morphine
1) Confidence 0.70 Published 1992 Journal Physiol. Behav. Section Abstract Doc Link 1336601 Disease Relevance 0 Pain Relevance 0.24
Serum TfR levels did not change with infection or painful crisis but were markedly elevated in hypersplenism and fell following splenectomy in these subjects.
Positive_regulation (elevated) of TfR associated with pain, hypersplenism and infection
2) Confidence 0.66 Published 1993 Journal Br. J. Haematol. Section Abstract Doc Link 8398834 Disease Relevance 1.28 Pain Relevance 0.10
GF120918 administration caused an unexpected increase in perfusate clearance in both control and TR- rat livers.
Positive_regulation (increase) of TR in livers
3) Confidence 0.43 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15302892 Disease Relevance 0 Pain Relevance 0.23
Increased plasma concentrations of interleukin-6, soluble interleukin-6, soluble interleukin-2 and transferrin receptor in major depression.
Positive_regulation (Increased) of transferrin receptor in plasma associated with depression
4) Confidence 0.19 Published 1995 Journal J Affect Disord Section Title Doc Link 8550956 Disease Relevance 0.34 Pain Relevance 0.27
1 and up-regulation of TR?
Positive_regulation (up-regulation) of TR
5) Confidence 0.11 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2977073 Disease Relevance 0.60 Pain Relevance 0.04
In contrast, an early (1 h) up-regulation of TR?
Positive_regulation (up-regulation) of TR
6) Confidence 0.11 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2977073 Disease Relevance 0 Pain Relevance 0.04
Likewise, an up-regulation of TR?
Positive_regulation (regulation) of TR
7) Confidence 0.11 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2977073 Disease Relevance 0 Pain Relevance 0.15
The lubricant effects of TR-FB and HB during tablet punching (pressure transmission ratio, ejection force) were similar to those of Mg-St and were better than those of SSE.
Positive_regulation (effects) of TR-FB
8) Confidence 0.02 Published 2005 Journal Int J Pharm Section Abstract Doc Link 15778041 Disease Relevance 0 Pain Relevance 0.13

General Comments

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