INT69966

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Context Info
Confidence 0.45
First Reported 1997
Last Reported 2008
Negated 1
Speculated 1
Reported most in Abstract
Documents 11
Total Number 13
Disease Relevance 6.18
Pain Relevance 4.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CPOX) small molecule metabolic process (CPOX) oxidoreductase activity (CPOX)
cytoplasm (CPOX)
Anatomy Link Frequency
nerve 2
skin 2
bladder 2
CPOX (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 105 100.00 Very High Very High Very High
aspirin 43 100.00 Very High Very High Very High
COX-2 inhibitor 29 100.00 Very High Very High Very High
COX2 6 99.94 Very High Very High Very High
diclofenac 54 96.24 Very High Very High Very High
licofelone 1 92.88 High High
Hyperalgesia 11 91.88 High High
Pain 28 89.16 High High
Inflammation 36 88.80 High High
antagonist 3 87.76 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 56 100.00 Very High Very High Very High
Hyperplasia 1 100.00 Very High Very High Very High
Apoptosis 8 99.96 Very High Very High Very High
Renal Failure 1 99.96 Very High Very High Very High
Cv General 4 Under Development 1 99.80 Very High Very High Very High
Hypoxia 3 99.00 Very High Very High Very High
Cirrhosis 7 98.72 Very High Very High Very High
Sepsis 51 98.68 Very High Very High Very High
Skin Ulcer 6 98.04 Very High Very High Very High
Cancer 63 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We tested the hypothesis that acute inhibition of cyclooxygenase (COX), the rate-limiting enzyme in prostanoid synthesis, impairs baroreflex regulation of cardiac period (R-R interval) and muscle sympathetic nerve activity (MSNA) in humans and augments pressor reactivity.
Positive_regulation (augments) of Negative_regulation (inhibition) of COX in nerve
1) Confidence 0.45 Published 2005 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15486039 Disease Relevance 0 Pain Relevance 0.18
In addition, we could show that inhibition of COX pathways did not increase the transformation of arachidonic acid by the 5-LOX pathway.
Neg (not) Positive_regulation (increase) of Negative_regulation (inhibition) of COX
2) Confidence 0.43 Published 2008 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 18280718 Disease Relevance 0 Pain Relevance 0.09
Thus, inhibition of COX-1 by non-steroidal anti-inflammatory drugs (NSAIDs) could increase the local ischaemia and hypoxia associated with chronic venous ulcers.
Positive_regulation (increase) of Negative_regulation (inhibition) of COX associated with inflammation, hypoxia, cv general 4 under development, cinod and skin ulcer
3) Confidence 0.29 Published 2001 Journal J. Pathol. Section Abstract Doc Link 11745699 Disease Relevance 1.17 Pain Relevance 0.37
Nonselective inhibition of cyclooxygenase (COX) by nonsteroidal anti-inflammatory drugs frequently induces renal failure in decompensated cirrhosis.
Positive_regulation (induces) of Negative_regulation (inhibition) of COX associated with cirrhosis, inflammation, renal failure and cinod
4) Confidence 0.29 Published 2005 Journal Hepatology Section Abstract Doc Link 15723448 Disease Relevance 0.62 Pain Relevance 0.13
Sodium salicylate acutely (30 min) also caused a concentration-dependent inhibition of COX-2 activity measured in the presence of 0, 1, or 10 microM exogenous arachidonic acid.
Positive_regulation (caused) of Negative_regulation (inhibition) of COX
5) Confidence 0.28 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9187256 Disease Relevance 0.32 Pain Relevance 0.34
Finally, treatment with COX-2 siRNAs downregulated the expression of COX-2 mRNA; furthermore, the siCOX-2-mediated suppression of COX-2 also resulted in suppression of aromatase mRNA.
Positive_regulation (resulted) of Negative_regulation (suppression) of COX
6) Confidence 0.27 Published 2005 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 15964185 Disease Relevance 0.35 Pain Relevance 0.24
An introduction to aspirin, NSAIDs, and COX-2 inhibitors for the primary prevention of cardiovascular events and cancer and their potential preventive role in bladder carcinogenesis: part I.
Positive_regulation (introduction) of Negative_regulation (inhibitors) of COX in bladder associated with aspirin, cancer, cinod and cox-2 inhibitor
7) Confidence 0.22 Published 2001 Journal Semin. Urol. Oncol. Section Title Doc Link 11769881 Disease Relevance 0.48 Pain Relevance 1.04
Histochemical and Western blot analyses of skin biopsies revealed a strong upregulation of COX-2, a slight decrease of COX-1 and activation of nuclear factor kappa B (NF-kappaB) in the area of the freezing injury.
Positive_regulation (upregulation) of Negative_regulation (decrease) of COX in skin associated with injury
8) Confidence 0.19 Published 2007 Journal Pain Section Abstract Doc Link 17189672 Disease Relevance 0.63 Pain Relevance 0.83
In vitro experimental studies find that COX-2 inhibitors decrease cellular proliferation, increase apoptosis, and modulate genes involved in cell cycle regulation.
Positive_regulation (increase) of Negative_regulation (inhibitors) of COX associated with cox-2 inhibitor, apoptosis and hyperplasia
9) Confidence 0.17 Published 2003 Journal Clin Prostate Cancer Section Abstract Doc Link 15040874 Disease Relevance 1.14 Pain Relevance 0.35
As shown in Figure 7C, for etoricoxib and diclofenac the individual values of achieved COX selectivity were placed above 1 (which represents a balanced inhibition of COX-2 and COX-1) showing that circulating concentrations of the two drugs caused a more profound inhibition of COX-2 than COX-1.
Positive_regulation (caused) of Negative_regulation (inhibition) of COX associated with diclofenac
10) Confidence 0.15 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621416 Disease Relevance 0.05 Pain Relevance 0.34
In contrast, naproxen and aspirin caused a more profound inhibition of COX-1 than COX-2; in fact the ratio of COX-2 /COX-1 inhibition ex vivo was always lower than 1.
Positive_regulation (caused) of Negative_regulation (inhibition) of COX associated with aspirin
11) Confidence 0.15 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621416 Disease Relevance 0.06 Pain Relevance 0.34
Cells (4 × 104 cells/ml) were plated with increasing concentrations of celecoxib (a specific COX-2 inhibitor; from 40 to 60 ?
Positive_regulation (increasing) of Negative_regulation (inhibitor) of COX associated with cox-2 inhibitor
12) Confidence 0.08 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1797025 Disease Relevance 0.21 Pain Relevance 0.08
The present study was therefore conducted to determine whether COX inhibition is upregulated early after the onset of severe sepsis, and if so whether COX inhibition prevents the occurrence of septic shock.
Spec (whether) Positive_regulation (upregulated) of Spec (whether) Negative_regulation (inhibition) of COX associated with sepsis
13) Confidence 0.04 Published 2004 Journal Crit Care Section Body Doc Link PMC1065065 Disease Relevance 1.15 Pain Relevance 0.31

General Comments

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