INT69967

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Context Info
Confidence 0.35
First Reported 1997
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 7.73
Pain Relevance 4.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CPOX) small molecule metabolic process (CPOX) oxidoreductase activity (CPOX)
cytoplasm (CPOX)
Anatomy Link Frequency
stomach 2
PGE2 2
CPOX (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 7 99.96 Very High Very High Very High
cINOD 40 99.78 Very High Very High Very High
Inflammation 106 99.76 Very High Very High Very High
cytokine 51 97.64 Very High Very High Very High
Pain 4 96.44 Very High Very High Very High
chemokine 29 96.00 Very High Very High Very High
Osteoarthritis 105 93.60 High High
aspirin 12 92.40 High High
COX-2 inhibitor 25 91.68 High High
Inflammatory stimuli 3 89.84 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 140 99.96 Very High Very High Very High
Apoptosis 13 98.24 Very High Very High Very High
Cancer 31 97.20 Very High Very High Very High
Disease 15 97.12 Very High Very High Very High
Pain 4 96.44 Very High Very High Very High
Pressure And Volume Under Development 4 96.08 Very High Very High Very High
Breast Cancer 56 93.80 High High
Osteoarthritis 106 93.60 High High
Ulcers 12 92.40 High High
Drug Induced Neurotoxicity 3 92.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, the identification of a cytokine-inducible isoform of COX, COX-2, has led to the suggestion that salicylate produces its anti-inflammatory actions by inhibiting COX-2 induction through actions on nuclear factor kappaB (NF-kappaB).
Negative_regulation (inhibiting) of Positive_regulation (induction) of COX associated with inflammation and cytokine
1) Confidence 0.35 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9187256 Disease Relevance 0.42 Pain Relevance 0.45
Classical NSAIDs like indomethacin inhibit both the constitutive COX-1 and the inducible COX-2 enzymes.
Negative_regulation (inhibit) of Positive_regulation (inducible) of COX associated with cinod
2) Confidence 0.30 Published 2005 Journal Neurochem. Int. Section Abstract Doc Link 16169124 Disease Relevance 0.89 Pain Relevance 0.49
However, in situations where the release of protective PGs by COX-1 has been lost, the induction of COX-2 may compensate and reduce inflammatory responses.
Negative_regulation (reduce) of Positive_regulation (induction) of COX associated with inflammatory response
3) Confidence 0.27 Published 1998 Journal Inflamm. Res. Section Abstract Doc Link 9831329 Disease Relevance 0.57 Pain Relevance 0.29
After characterization of the COX-1 enzyme in 1976, a second COX gene was discovered in 1991 encoding for the inducible COX-2.
Negative_regulation (discovered) of Positive_regulation (inducible) of COX
4) Confidence 0.22 Published 1998 Journal Int J Tissue React Section Abstract Doc Link 9561441 Disease Relevance 0.39 Pain Relevance 0.43
The selectivity of S(+) flurbiprofen for inhibition of constitutively present COX-1, relative to the inhibition of induced COX-2, was 3,600.
Negative_regulation (inhibition) of Positive_regulation (induced) of COX
5) Confidence 0.15 Published 2000 Journal J Ocul Pharmacol Ther Section Abstract Doc Link 10977131 Disease Relevance 0 Pain Relevance 0.04
In order to reduce the gastroduodenal side-effects of NSAIDs, selective cyclo-oxygenase (COX)-2 inhibitors have been developed, which inhibit the inducible COX-2 isoform in inflammatory tissue but have only limited effect on the constitutive COX-1 isoform in the stomach.
Negative_regulation (inhibit) of Positive_regulation (inducible) of COX in stomach associated with inflammation and cinod
6) Confidence 0.15 Published 1998 Journal Am. J. Med. Section Abstract Doc Link 9572320 Disease Relevance 1.35 Pain Relevance 0.67
Selective inhibitors of sulindac sulfide-induced ERKp44/42 (PD98059) and p38 MAPK (SB203580) activation also suppressed the induction of COX-2 by this NSAID.
Negative_regulation (suppressed) of Positive_regulation (induction) of COX associated with cinod
7) Confidence 0.14 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15657353 Disease Relevance 0.74 Pain Relevance 0.34
Furthermore, the inhibition of eicosanoid production by the action of nonsteroidal anti-inflammatory drugs or by the prevention of COX-2 induction with the p38 mitogen-activated protein kinase inhibitor SKF86002 was greater for PGE2 than for TXA2.
Negative_regulation (prevention) of Positive_regulation (induction) of COX in PGE2 associated with inflammation and cinod
8) Confidence 0.12 Published 2000 Journal J. Immunol. Section Abstract Doc Link 10903770 Disease Relevance 0.10 Pain Relevance 0.19
These later compounds are aimed at decreasing the inducible COX-2 activity responsible for prostaglandin synthesis.
Negative_regulation (decreasing) of Positive_regulation (inducible) of COX
9) Confidence 0.06 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.86 Pain Relevance 0.65
COX-2 induction and the resulting production of arachidonic acid metabo-lites could similarly be inhibited by treatment with dexa-methasone [13,51].
Negative_regulation (inhibited) of Positive_regulation (induction) of COX
10) Confidence 0.04 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 1.06 Pain Relevance 0.48
Other studies have suggested that high concentrations of COX inhibitors (over 25 ?
Negative_regulation (inhibitors) of Positive_regulation (concentrations) of COX
11) Confidence 0.04 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1559713 Disease Relevance 1.37 Pain Relevance 0.04

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