INT69974

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Context Info
Confidence 0.70
First Reported 1997
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 30
Total Number 35
Disease Relevance 2.44
Pain Relevance 5.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oxtr) response to stress (Oxtr) signal transducer activity (Oxtr)
Anatomy Link Frequency
smooth muscle 2
uterine 2
horn 2
fundus 2
epithelial cells 1
Oxtr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 61 99.56 Very High Very High Very High
Action potential 75 99.46 Very High Very High Very High
fluoxetine 6 99.16 Very High Very High Very High
withdrawal 12 99.08 Very High Very High Very High
cocaine 10 98.86 Very High Very High Very High
Pain 21 98.56 Very High Very High Very High
amygdala 25 98.28 Very High Very High Very High
Cholecystokinin 19 97.84 Very High Very High Very High
antagonist 172 97.44 Very High Very High Very High
COX2 3 96.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 67 99.16 Very High Very High Very High
Pain 22 98.56 Very High Very High Very High
Urological Neuroanatomy 17 97.04 Very High Very High Very High
Dysmenorrhea 11 95.60 Very High Very High Very High
Breast Cancer 1 93.92 High High
Generalized Anxiety Disorder 7 87.76 High High
Stroke 4 83.48 Quite High
Aggression 6 81.80 Quite High
Shock 46 75.00 Quite High
Critical Illness 1 66.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increase of OTR mRNA in cervical epithelial cells was minimal in all situations.
Positive_regulation (increase) of OTR mRNA in epithelial cells
1) Confidence 0.70 Published 1998 Journal Biol. Reprod. Section Abstract Doc Link 9780319 Disease Relevance 0 Pain Relevance 0.10
Whereas estrogen administration strongly induced the uterine OTR mRNA levels (>5-fold), mammary gland remained unaffected by steroid treatment.
Positive_regulation (induced) of OTR mRNA in uterine
2) Confidence 0.70 Published 2001 Journal J. Mol. Endocrinol. Section Abstract Doc Link 11564602 Disease Relevance 0 Pain Relevance 0
Fenoterol in vivo elicited a maximum 125% increase of OTR mRNA, in vitro produced a maximum fourfold increase in OTR mRNA.
Positive_regulation (increase) of OTR mRNA
3) Confidence 0.69 Published 2004 Journal Mol. Reprod. Dev. Section Abstract Doc Link 15278905 Disease Relevance 0 Pain Relevance 0.22
Fenoterol in vivo elicited a maximum 125% increase of OTR mRNA, in vitro produced a maximum fourfold increase in OTR mRNA.
Positive_regulation (increase) of OTR mRNA
4) Confidence 0.69 Published 2004 Journal Mol. Reprod. Dev. Section Abstract Doc Link 15278905 Disease Relevance 0 Pain Relevance 0.21
Hexoprenaline induced a maximum 24% increase of OTR mRNA.
Positive_regulation (increase) of OTR mRNA
5) Confidence 0.69 Published 2004 Journal Mol. Reprod. Dev. Section Abstract Doc Link 15278905 Disease Relevance 0 Pain Relevance 0.20
Cocaine and fluoxetine treatment both resulted in a significant up-regulation of oxytocin receptor number and lower receptor affinity in the amygdala of lactating rat dams compared to saline controls and the amfonelic acid/fluoxetine combination treatment group.
Positive_regulation (up-regulation) of oxytocin receptor in amygdala associated with amygdala, fluoxetine and cocaine
6) Confidence 0.65 Published 2004 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 15380831 Disease Relevance 0.39 Pain Relevance 1.13
Estradiol-dependent activation of OTR gene expression and active OTR synthesis in smooth muscle cells account for the increased OTR level in rat cervix in vivo, in which progesterone acted as an antagonist of estradiol on OTR gene expression.
Positive_regulation (increased) of OTR in smooth muscle cells associated with antagonist
7) Confidence 0.61 Published 1998 Journal Biol. Reprod. Section Abstract Doc Link 9780319 Disease Relevance 0 Pain Relevance 0.10
Up-regulation of oxytocin receptor messenger ribonucleic acid and protein by estradiol in the cervix of ovariectomized rat.
Positive_regulation (Up-regulation) of oxytocin receptor in cervix
8) Confidence 0.50 Published 1998 Journal Biol. Reprod. Section Title Doc Link 9780319 Disease Relevance 0 Pain Relevance 0.08
Progesterone alone had no effect on OTR mRNA expression; however, progesterone combined with estradiol significantly inhibited the up-regulation of OTR mRNA by estradiol alone.
Positive_regulation (up-regulation) of OTR mRNA
9) Confidence 0.50 Published 1998 Journal Biol. Reprod. Section Abstract Doc Link 9780319 Disease Relevance 0 Pain Relevance 0.07
These results suggest that the OTR is expressed on the smooth muscle of the stomach and mediates excitatory effect of OT on gastric motility.
Positive_regulation (mediates) of OTR in smooth muscle
10) Confidence 0.50 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19309416 Disease Relevance 0 Pain Relevance 0.21
OTR activation leads to the stimulation of phospholipase A2 production and an increase in cyclooxygenase 2 levels, both resulting in increased prostaglandin production.
Positive_regulation (activation) of OTR associated with cox2
11) Confidence 0.45 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2972642 Disease Relevance 0.11 Pain Relevance 0.05
Physical GRK2/OTR association was further demonstrated by coimmunoprecipitation of endogenous GRK2 with activated OTR.
Positive_regulation (activated) of OTR
12) Confidence 0.34 Published 2004 Journal Mol. Endocrinol. Section Abstract Doc Link 14976224 Disease Relevance 0.07 Pain Relevance 0.14
Mechanical stretch appears largely responsible for increased OTR mRNA and to a lesser degree PGHS2 mRNA.
Spec (appears) Positive_regulation (increased) of OTR
13) Confidence 0.31 Published 1999 Journal Endocrinology Section Abstract Doc Link 10579336 Disease Relevance 0.07 Pain Relevance 0
ERalpha, Hsp90, OTR, and PGHS2 mRNA were all significantly up-regulated during betamethasone-induced labor (P < 0.01) in gravid and nongravid horn myometrium.
Positive_regulation (up-regulated) of OTR in horn
14) Confidence 0.31 Published 1999 Journal Endocrinology Section Abstract Doc Link 10579336 Disease Relevance 0.07 Pain Relevance 0.07
In addition, endocrine factors may be required for full activation of OTR and PGHS2 mRNA associated with labor.
Positive_regulation (activation) of OTR
15) Confidence 0.31 Published 1999 Journal Endocrinology Section Abstract Doc Link 10579336 Disease Relevance 0.07 Pain Relevance 0
The mechanism of this inhibition was based on the oxytocin receptor leading to the activation of protein kinase A and the elevation of intracellular Ca2+, thus corroborating our data.
Positive_regulation (leading) of oxytocin receptor
16) Confidence 0.30 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2972642 Disease Relevance 0 Pain Relevance 0.09
The increased OTR mRNA may serve as a mechanism to increase uterine sensitivity to OT during late gestation.
Positive_regulation (increased) of OTR in uterine
17) Confidence 0.28 Published 2001 Journal J. Endocrinol. Section Abstract Doc Link 11739010 Disease Relevance 0 Pain Relevance 0.08
Then, OTR activation leads to parallel signaling pathways that can converge on a common target.
Positive_regulation (activation) of OTR
18) Confidence 0.26 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2972642 Disease Relevance 0 Pain Relevance 0.12
Furthermore, variations in maternal care that are associated with increased OTR also increase ER?
Positive_regulation (increased) of OTR
19) Confidence 0.25 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2048512 Disease Relevance 0.38 Pain Relevance 0.17
Classically, the effects of vasopressin on the heart were thought to be mediated through the V1R (vascular smooth muscle/calcium-dependent effect) or OTR (endothelial/NO effect).
Positive_regulation (mediated) of OTR in smooth muscle
20) Confidence 0.24 Published 2004 Journal Crit Care Section Body Doc Link PMC420051 Disease Relevance 0.30 Pain Relevance 0.04

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