INT69980

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Context Info
Confidence 0.33
First Reported 1997
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 7.75
Pain Relevance 6.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1rn) extracellular region (Il1rn) nucleus (Il1rn)
lipid metabolic process (Il1rn) cytoplasm (Il1rn)
Anatomy Link Frequency
spinal cord 1
Il1rn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 10 99.96 Very High Very High Very High
Hyperalgesia 6 99.52 Very High Very High Very High
analgesia 12 99.08 Very High Very High Very High
electroacupuncture 9 99.00 Very High Very High Very High
Pain 16 98.56 Very High Very High Very High
Inflammation 36 98.04 Very High Very High Very High
allodynia 5 98.04 Very High Very High Very High
Spinal cord 9 97.68 Very High Very High Very High
Thermal hyperalgesia 4 97.48 Very High Very High Very High
intrathecal 4 96.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Serositis 1 99.68 Very High Very High Very High
Hyperalgesia 10 99.52 Very High Very High Very High
Appetite Loss 1 99.40 Very High Very High Very High
Fever 3 99.20 Very High Very High Very High
Disease 50 98.88 Very High Very High Very High
Pain 14 98.56 Very High Very High Very High
INFLAMMATION 29 98.04 Very High Very High Very High
Neuropathic Pain 5 98.04 Very High Very High Very High
Hypertension 8 97.88 Very High Very High Very High
Anxiety Disorder 4 97.86 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We observed that: (1) intracerebral ventricular injection of (ICV) IL-1beta induced pressor responses; (2) hypertension induced by IL-1beta was blocked by ICV an IL-1 antagonist, IL-1ra; (3) ICV IL-1ra attenuated the pressor response induced by FS but intravenous injection of IL-1ra did not significantly reduce this response; (4) the hypertensive response to conditioned fear stimuli was reversed by ICV IL-1ra; (5) FS-induced-analgesia was attenuated by ICV IL-1ra and this effect disappeared 15 min after ICV IL-1ra.
Negative_regulation (disappeared) of IL-1ra associated with antagonist, anxiety disorder, hypertension and analgesia
1) Confidence 0.33 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11585563 Disease Relevance 0.60 Pain Relevance 0.39
We observed that: (1) intracerebral ventricular injection of (ICV) IL-1beta induced pressor responses; (2) hypertension induced by IL-1beta was blocked by ICV an IL-1 antagonist, IL-1ra; (3) ICV IL-1ra attenuated the pressor response induced by FS but intravenous injection of IL-1ra did not significantly reduce this response; (4) the hypertensive response to conditioned fear stimuli was reversed by ICV IL-1ra; (5) FS-induced-analgesia was attenuated by ICV IL-1ra and this effect disappeared 15 min after ICV IL-1ra.
Negative_regulation (injection) of IL-1ra associated with antagonist, anxiety disorder, hypertension and analgesia
2) Confidence 0.33 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11585563 Disease Relevance 0.62 Pain Relevance 0.38
CONCLUSION(S): Our results suggested that decreased levels of PF IL-1ra in patients with endometriosis and disease-related dysmenorrhea may play an important role in the pathogenesis of this disease.


Negative_regulation (decreased) of PF IL-1ra
3) Confidence 0.17 Published 2007 Journal Fertil. Steril. Section Body Doc Link 17292896 Disease Relevance 0.06 Pain Relevance 0
By contrast, PPT elevations produced by EA were dose-dependently antagonized by local i.pl. injection of alpha-helical CRF or IL-1ra.
Negative_regulation (injection) of IL-1ra associated with electroacupuncture
4) Confidence 0.16 Published 2004 Journal Am. J. Chin. Med. Section Abstract Doc Link 15315264 Disease Relevance 0.54 Pain Relevance 1.33
In behavioural studies, intrathecal injection of LPS in the lumbar spinal cord produced mechanical hyperalgesia in the rat hind-paws which was attenuated by concomitant injections of a p38 MAPK inhibitor, a caspase 1 inhibitor or the rat recombinant interleukin 1 receptor antagonist.
Negative_regulation (inhibitor) of interleukin 1 receptor in spinal cord associated with hyperalgesia, antagonist, spinal cord and intrathecal
5) Confidence 0.14 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16942597 Disease Relevance 0.56 Pain Relevance 0.70
I.t. pretreatment of IL-1 receptor antagonist (IL-1ra), p38 MAPK inhibitor or iNOS inhibitor, inhibits the i.t.
Negative_regulation (inhibitor) of IL-1ra associated with antagonist
6) Confidence 0.08 Published 2007 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Abstract Doc Link 17694686 Disease Relevance 0.69 Pain Relevance 0.93
I.t. pretreatment of IL-1 receptor antagonist (IL-1ra), p38 MAPK inhibitor or iNOS inhibitor, inhibits the i.t.
Negative_regulation (inhibitor) of IL-1ra associated with antagonist
7) Confidence 0.08 Published 2007 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Abstract Doc Link 17694686 Disease Relevance 0.69 Pain Relevance 0.93
Blockade of interleukin-1 (IL1) inhibited hyperalgesia induced by both sPLA2s, while leaving allodynia unaffected.
Negative_regulation (Blockade) of IL1 associated with hyperalgesia and allodynia
8) Confidence 0.04 Published 2004 Journal Pain Section Abstract Doc Link 15327810 Disease Relevance 1.11 Pain Relevance 1.09
Dexamethasone, IL-1-Ra and TNF inhibitor decreased active MMP-3, indicating that the clinical use of these drugs may affect the resorption of DH under certain conditions.


Negative_regulation (inhibitor) of IL-1-Ra
9) Confidence 0.02 Published 2009 Journal Arthritis Res. Ther. Section Body Doc Link 19906289 Disease Relevance 0 Pain Relevance 0
In contrast, IL-1ra and sTNFR-1 are inhibitors of IL-1 and TNF-?
Negative_regulation (inhibitors) of IL-1ra
10) Confidence 0.01 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3022224 Disease Relevance 1.05 Pain Relevance 0.36
The treatment was well tolerated and induced rapid control of fever, anorexia and serositis, together with downregulation of interleukin (IL)-6, soluble TNF receptors (sTNFR) and IL-1ra, and the acute-phase proteins C-reactive protein (CRP) and serum amyloid A (SAA).
Negative_regulation (downregulation) of IL-1ra associated with appetite loss, alzheimer's dementia, serositis and fever
11) Confidence 0.01 Published 1997 Journal Br. J. Rheumatol. Section Abstract Doc Link 9189062 Disease Relevance 1.84 Pain Relevance 0.58

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