INT69981

Context Info Confidence 0.09 First Reported 1997 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 3 Disease Relevance 3.28 Pain Relevance 2.48

extracellular space (Il1rn) extracellular region (Il1rn) nucleus (Il1rn) lipid metabolic process (Il1rn) cytoplasm (Il1rn)

Il1rn (Rattus norvegicus)

Pain Link Frequency Relevance Heat antagonist 2 100.00 allodynia 2 99.72 Thermal hyperalgesia 4 99.16 nociceptor 2 97.80 Arthritis 8 93.08 Pain 7 88.88 intrathecal 2 88.68 Spinal cord 4 87.08 rheumatoid arthritis 3 85.24 cytokine 1 82.00

Disease Link Frequency Relevance Heat Fever 3 100.00 Appetite Loss 1 100.00 Serositis 1 100.00 Neuropathic Pain 2 99.72 Hyperalgesia 4 99.16 Alzheimer's Dementia 1 97.36 Juvenile Chronic Polyarthritis 7 93.08 Arthritis 1 91.04 Arthralgia 1 89.36 Nociception 4 87.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

I.t. pretreatment of IL-1 receptor antagonist (IL-1ra), p38 MAPK inhibitor or iNOS inhibitor, inhibits the i.t.

Positive_regulation (pretreatment) of Negative_regulation (inhibitor) of IL-1ra associated with antagonist

1) Confidence 0.09 Published 2007 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Abstract Doc Link 17694686 Disease Relevance 0.70 Pain Relevance 0.94

I.t. pretreatment of IL-1 receptor antagonist (IL-1ra), p38 MAPK inhibitor or iNOS inhibitor, inhibits the i.t.

Positive_regulation (pretreatment) of Negative_regulation (inhibitor) of IL-1ra associated with antagonist

2) Confidence 0.09 Published 2007 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Abstract Doc Link 17694686 Disease Relevance 0.70 Pain Relevance 0.94

The treatment was well tolerated and induced rapid control of fever, anorexia and serositis, together with downregulation of interleukin (IL)-6, soluble TNF receptors (sTNFR) and IL-1ra, and the acute-phase proteins C-reactive protein (CRP) and serum amyloid A (SAA).

Positive_regulation (induced) of Negative_regulation (downregulation) of IL-1ra associated with appetite loss, alzheimer's dementia, serositis and fever

3) Confidence 0.01 Published 1997 Journal Br. J. Rheumatol. Section Abstract Doc Link 9189062 Disease Relevance 1.88 Pain Relevance 0.59

General Comments

This test has worked.