INT69989

Context Info Confidence 0.43 First Reported 1997 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.44 Pain Relevance 0.67

structural molecule activity (Nefl) locomotion (Nefl) response to stress (Nefl)

Anatomy Link Frequency frontal cortex 2 Nefl (Rattus norvegicus)

Pain Link Frequency Relevance Heat methadone 1 96.84 opiate 5 95.00 Morphine 1 89.40 induced neuropathy 1 72.80

Disease Link Frequency Relevance Heat Urological Neuroanatomy 1 99.12 Overdose 1 97.20 Drug Induced Neurotoxicity 2 84.12 Neurodegenerative Disease 1 79.36 Neuropathic Pain 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Levels of immunoreactive NF-L proteins were markedly decreased (47%, n = 17) in the frontal cortex.

Negative_regulation (decreased) of Gene_expression (Levels) of NF-L in frontal cortex associated with urological neuroanatomy

1) Confidence 0.43 Published 1997 Journal Neuroreport Section Abstract Doc Link 9189892 Disease Relevance 0.20 Pain Relevance 0.59

Compared with the control, the levels of NF-L, NF-M, NF-H, beta-actin, tau, MAP2 proteins decreased and the level of alpha-tubulin increased in high ACR group, the levels of alpha-tubulin, beta-tubulin and MAP2 increased in low ACR group.

Negative_regulation (decreased) of Gene_expression (levels) of NF-L

2) Confidence 0.27 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 16845587 Disease Relevance 0.25 Pain Relevance 0.07

General Comments

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