INT69990

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Context Info
Confidence 0.59
First Reported 1997
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 2.82
Pain Relevance 3.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Nefl) locomotion (Nefl) response to stress (Nefl)
Anatomy Link Frequency
nerves 2
plasma 1
retina 1
cerebral cortex 1
brains 1
Nefl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 15 99.04 Very High Very High Very High
cerebral cortex 5 98.32 Very High Very High Very High
methadone 3 95.84 Very High Very High Very High
Neuritis 6 94.92 High High
Sciatic nerve 9 93.92 High High
Spinal cord 5 92.96 High High
Morphine 3 91.88 High High
induced neuropathy 4 79.92 Quite High
Demyelination 2 75.52 Quite High
Central nervous system 1 72.32 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 3 99.76 Very High Very High Very High
Diabetes Mellitus 71 98.94 Very High Very High Very High
Overdose 4 96.20 Very High Very High Very High
Optic Neuritis 6 95.16 Very High Very High Very High
Drug Induced Neurotoxicity 4 83.72 Quite High
Neuropathic Pain 6 83.60 Quite High
Neurodegenerative Disease 1 78.96 Quite High
Nerve Degeneration 1 77.68 Quite High
Demyelinating Disease 2 75.52 Quite High
Frailty 1 74.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Levels of immunoreactive NF-L proteins were markedly decreased (47%, n = 17) in the frontal cortex.
Negative_regulation (decreased) of NF-L in frontal cortex associated with urological neuroanatomy
1) Confidence 0.59 Published 1997 Journal Neuroreport Section Abstract Doc Link 9189892 Disease Relevance 0.20 Pain Relevance 0.59
Marked decrease of immunolabelled 68 kDa neurofilament (NF-L) proteins in brains of opiate addicts.
Negative_regulation (decrease) of NF-L in brains associated with opiate
2) Confidence 0.59 Published 1997 Journal Neuroreport Section Title Doc Link 9189892 Disease Relevance 0.16 Pain Relevance 0.57
The reduced abundance of brain NF-L proteins was not related to the post-mortem delay or to the plasma concentrations of opiates, suggesting that the observed changes represent a specific long-term effect of opiate drugs.
Negative_regulation (reduced) of NF-L in plasma associated with opiate
3) Confidence 0.43 Published 1997 Journal Neuroreport Section Abstract Doc Link 9189892 Disease Relevance 0.19 Pain Relevance 0.61
Results showed that in the pellet fraction, the contents of three NF subunits in both treated groups decreased significantly except NF-L in low dose group.
Neg (except) Negative_regulation (decreased) of NF-L
4) Confidence 0.37 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 17120161 Disease Relevance 0.06 Pain Relevance 0.10
Results showed that the three neurofilament (NF) subunits (NF-L, NF-M, NF-H) in both the pellet and the supernatant fraction decreased significantly (P < 0.01) in the high-dosing group, except for NF-M in the pellet. alpha-tubulin, beta-tubulin, and beta-actin increased significantly in the supernatant (P < 0.01), whereas both alpha-tubulin and beta-tubulin decreased significantly in the pellet (P < 0.01).
Negative_regulation (decreased) of NF-L
5) Confidence 0.26 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 17043767 Disease Relevance 0.31 Pain Relevance 0.26
Results showed myelin associated glycoprotein and 68 kD neurofilament protein levels were significantly decreased while calpain translational expression and calpain-autolyzed fodrin levels were significantly increased in experimental optic neuritis compared to controls.
Negative_regulation (decreased) of 68 kD neurofilament protein in optic associated with optic neuritis and neuritis
6) Confidence 0.26 Published 1999 Journal Histol. Histopathol. Section Abstract Doc Link 10212825 Disease Relevance 0.57 Pain Relevance 0.61
The levels of neurofilaments (NFs) subunits (NF-L, NF-M and NF-H) in nerve tissues of 200 and 400mg/kg HD rats significantly decreased in both the supernatant and pellet fractions.
Negative_regulation (decreased) of NF-L in nerve
7) Confidence 0.25 Published 2008 Journal Toxicology Section Abstract Doc Link 18177991 Disease Relevance 0.08 Pain Relevance 0.26
Therefore, we suggest that the axonal degeneration in STZ-induced diabetic rats was reflected by the distorted circularity and decreased NF-H, NF-M, and NF-L in the distal sural nerves of STZ-induced diabetic rats.
Negative_regulation (decreased) of NF-L in nerves associated with diabetes mellitus
8) Confidence 0.25 Published 2008 Journal Diabetes Section Body Doc Link PMC2570407 Disease Relevance 1.00 Pain Relevance 0.18
Compared with the control, the levels of NF-L, NF-M, NF-H, beta-actin, tau, MAP2 proteins decreased and the level of alpha-tubulin increased in high ACR group, the levels of alpha-tubulin, beta-tubulin and MAP2 increased in low ACR group.
Negative_regulation (decreased) of NF-L
9) Confidence 0.12 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 16845587 Disease Relevance 0.24 Pain Relevance 0.07
The NFL and IPL were chosen to be measured in their labeling intensity as these layers of the retina showed the highest intensity of continuous specific labeling across all eccentricities of the retina.
Negative_regulation (measured) of NFL in retina
10) Confidence 0.07 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254964 Disease Relevance 0 Pain Relevance 0
We demonstrated that pre-treatment of cerebral cortex slices of young rats with 2.5 mM buffered methylmalonic acid (MMA) is effective in decreasing in vitro incorporation of [32P]ATP into neurofilament subunits (NF-M and NF-L) and alpha- and beta-tubulins.
Negative_regulation (decreasing) of NF-L in cerebral cortex associated with cerebral cortex
11) Confidence 0.06 Published 1997 Journal Brain Res. Section Abstract Doc Link 9296563 Disease Relevance 0 Pain Relevance 0.13

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