INT69992

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Context Info
Confidence 0.50
First Reported 1997
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 93
Total Number 96
Disease Relevance 49.01
Pain Relevance 44.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Hmox2) endoplasmic reticulum (Hmox2) plasma membrane (Hmox2)
Anatomy Link Frequency
upper 4
platelet 2
plasma 1
liver 1
bowel 1
Hmox2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 113 100.00 Very High Very High Very High
COX2 47 100.00 Very High Very High Very High
aspirin 43 100.00 Very High Very High Very High
cOX1 12 100.00 Very High Very High Very High
cINOD 408 99.98 Very High Very High Very High
Paracetamol 62 99.92 Very High Very High Very High
Analgesic 37 99.82 Very High Very High Very High
corticosteroid 3 99.80 Very High Very High Very High
diclofenac 81 99.74 Very High Very High Very High
Inflammation 98 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ulcers 51 100.00 Very High Very High Very High
Colon Cancer 8 100.00 Very High Very High Very High
Pancreatitis 4 100.00 Very High Very High Very High
Injury 26 99.92 Very High Very High Very High
Esophageal Cancer 1 99.92 Very High Very High Very High
INFLAMMATION 276 99.86 Very High Very High Very High
Pain 111 99.56 Very High Very High Very High
Hypoalagesia 8 99.56 Very High Very High Very High
Pressure And Volume Under Development 18 99.48 Very High Very High Very High
Arthritis 26 99.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of cyclo-oxygenase-2 can lead to peripheral oedema and hypertension, and may promote thrombosis.
Negative_regulation (Inhibition) of cyclo-oxygenase-2 associated with pressure and volume under development and thrombosis
1) Confidence 0.50 Published 2001 Journal Dig Liver Dis Section Abstract Doc Link 11827359 Disease Relevance 0.83 Pain Relevance 0.22
BACKGROUND: Clinical trials have shown rofecoxib, a selective inhibitor of cyclo-oxygenase-2, to be associated with fewer gastrointestinal complications than non-selective nonsteroidal anti-inflammatory drugs (NSAIDs).
Negative_regulation (inhibitor) of cyclo-oxygenase-2 associated with inflammation and cinod
2) Confidence 0.50 Published 2001 Journal Pharmacoeconomics Section Abstract Doc Link 11735672 Disease Relevance 0.17 Pain Relevance 0.31
Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which preferentially inhibits cyclo-oxygenase 2 and has been associated with a total of 13 reported cases of severe liver injury including our case.
Negative_regulation (inhibits) of cyclo-oxygenase 2 in liver associated with inflammation, injury and cinod
3) Confidence 0.49 Published 2001 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 11549211 Disease Relevance 0.62 Pain Relevance 0.20
Although the precise mechanism(s) by which these drugs inhibit tumour growth is not completely understood, it is likely that at least a part of their anti-tumorigenic effects results from an inhibition of the cyclo-oxygenase-2 enzyme.
Negative_regulation (inhibition) of cyclo-oxygenase-2 enzyme associated with cancer
4) Confidence 0.48 Published 2002 Journal Best Pract Res Clin Gastroenterol Section Abstract Doc Link 12473300 Disease Relevance 0.68 Pain Relevance 0.09
The current literature with regard to systemic analgesia supports the concept of multimodal analgesia with an emphasis on the widespread use of appropriate nonopioids including NSAIDs or cyclo-oxygenase-2 inhibitors.
Negative_regulation (inhibitors) of cyclo-oxygenase-2
5) Confidence 0.48 Published 2009 Journal Curr Opin Anaesthesiol Section Body Doc Link 19606022 Disease Relevance 0 Pain Relevance 0
In ten large, well-controlled, randomised trials (n = 203 to 1089), valdecoxib, a selective inhibitor of cyclo-oxygenase-2, was significantly more effective than placebo in the treatment of osteoarthritis, rheumatoid arthritis and pain associated with primary dysmenorrhoea, and for postsurgical analgesia.
Negative_regulation (inhibitor) of cyclo-oxygenase-2 associated with pain, dismenorea, rheumatoid arthritis, osteoarthritis and analgesia
6) Confidence 0.48 Published 2002 Journal Drugs Section Abstract Doc Link 12269850 Disease Relevance 0.65 Pain Relevance 0.55
Parecoxib (parecoxib sodium) is an injectable pro drug of valdecoxib, which is a potent and selective inhibitor of cyclo-oxygenase-2.
Negative_regulation (inhibitor) of cyclo-oxygenase-2
7) Confidence 0.48 Published 2001 Journal Drugs Section Abstract Doc Link 11465874 Disease Relevance 0.08 Pain Relevance 0.64
The authors report two cases of myocardial infarction in patients considered to be at low risk treated by type 2 cyclo-oxygenase inhibitors.
Negative_regulation (inhibitors) of type 2 cyclo-oxygenase associated with myocardial infarction
8) Confidence 0.39 Published 2003 Journal Arch Mal Coeur Vaiss Section Abstract Doc Link 12868352 Disease Relevance 0.35 Pain Relevance 0.22
Cyclo-oxygenase-2 inhibitors appear to be safer to the small intestine than traditional NSAIDs.
Negative_regulation (inhibitors) of Cyclo-oxygenase-2 in small intestine associated with cinod
9) Confidence 0.38 Published 2000 Journal J Pharm Pharm Sci Section Abstract Doc Link 10954683 Disease Relevance 0.74 Pain Relevance 0.89
Our objective was to determine the efficacy and safety of valdecoxib (a cyclo-oxygenase 2 inhibitor) in the treatment of arthritis.
Negative_regulation (inhibitor) of cyclo-oxygenase 2 associated with arthritis
10) Confidence 0.37 Published 2004 Journal Pain Section Abstract Doc Link 15363872 Disease Relevance 0.90 Pain Relevance 0.59
Two had relapsed after taking a cyclo-oxygenase 2 inhibitor.
Negative_regulation (inhibitor) of cyclo-oxygenase 2
11) Confidence 0.37 Published 2004 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 15569105 Disease Relevance 0.23 Pain Relevance 0
Indeed, there is recent evidence of increased rates of myocardial infarction in arthritis patients taking a selective cyclo-oxygenase-2 inhibitor.
Negative_regulation (inhibitor) of cyclo-oxygenase-2 associated with myocardial infarction and arthritis
12) Confidence 0.37 Published 2001 Journal Dig Liver Dis Section Abstract Doc Link 11827359 Disease Relevance 0.97 Pain Relevance 0.24
The incidence of non-steroidal anti-inflammatory drug-related ulcer complications remains high despite the availability of potent anti-ulcer drugs and selective cyclo-oxygenase-2 inhibitors.
Negative_regulation (inhibitors) of cyclo-oxygenase-2 associated with inflammation and ulcers
13) Confidence 0.37 Published 2004 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 15142194 Disease Relevance 0.85 Pain Relevance 0.25
BACKGROUND: Case reports have suggested that the use of newer cyclo-oxygenase-2 selective inhibitors may cause acute pancreatitis, but there has been no formal study of the association.
Negative_regulation (inhibitors) of cyclo-oxygenase-2 associated with pancreatitis
14) Confidence 0.37 Published 2006 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 16803609 Disease Relevance 0.25 Pain Relevance 0.07
Current recommendations regarding strategies using anti-ulcer drugs and cyclo-oxygenase-2 inhibitors for prevention of clinical non-steroidal anti-inflammatory drug upper gastrointestinal events are largely derived from studies using surrogates such as endoscopic ulcers, erosions, and symptoms in low- to average-risk patients.
Negative_regulation (inhibitors) of cyclo-oxygenase-2 in upper associated with inflammation and ulcers
15) Confidence 0.37 Published 2004 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 15142194 Disease Relevance 1.05 Pain Relevance 0.36
Use of low-dose aspirin concurrently with use of a selective cyclo-oxygenase-2 inhibitor may provide some degree of protection against the potential cardiovascular toxicity of the latter but both laboratory and clinical studies suggest that the concomitant use of these two types of drugs results in gastrointestinal ulceration comparable to what is seen with conventional non-steroidal anti-inflammatory drugs.
Negative_regulation (inhibitor) of cyclo-oxygenase-2 associated with aspirin, toxicity, inflammation and cinod
16) Confidence 0.37 Published 2001 Journal Dig Liver Dis Section Abstract Doc Link 11827359 Disease Relevance 0.99 Pain Relevance 0.29
The introduction of selective inhibitors of cyclo-oxygenase-2 to the marketplace has been much anticipated for several years.
Negative_regulation (inhibitors) of cyclo-oxygenase-2
17) Confidence 0.37 Published 2001 Journal Dig Liver Dis Section Abstract Doc Link 11827359 Disease Relevance 0.24 Pain Relevance 0.08
AIM: To assess the relationship between the use of cyclo-oxygenase-2 inhibitors and other non-steroidal anti-inflammatory drugs, and risk of acute pancreatitis.
Negative_regulation (inhibitors) of cyclo-oxygenase-2
18) Confidence 0.37 Published 2006 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 16803609 Disease Relevance 0.10 Pain Relevance 0
Cyclo-oxygenase-2 inhibitors : beneficial or detrimental for athletes with acute musculoskeletal injuries?
Negative_regulation (inhibitors) of Cyclo-oxygenase-2 associated with injury and cox2
19) Confidence 0.37 Published 2005 Journal Sports Med Section Title Doc Link 15831058 Disease Relevance 0.76 Pain Relevance 0.58
We propose management strategies based on the risk category: low risk (absence of risk factors) (least ulcerogenic non-steroidal anti-inflammatory drug at lowest effective dose), moderate risk (one to two risk factors) (as above, plus an antisecretory agent or misoprostol or a cyclo-oxygenase-2 inhibitor), high risk (multiple risk factors or patients using concomitant low-dose aspirin, steroids, or anticoagulants) (cyclo-oxygenase-2 inhibitor alone with steroids, plus misoprostol with warfarin, or plus a proton pump inhibitors or misoprostol with aspirin), and very high risk (history of ulcer complications) (avoid all non-steroidal anti-inflammatory drugs, if possible or a cyclo-oxygenase-2 plus a proton pump inhibitors and/or misoprostol).
Negative_regulation (inhibitors) of cyclo-oxygenase-2 associated with aspirin, inflammation, ulcers and cinod
20) Confidence 0.37 Published 2004 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 15142194 Disease Relevance 0.85 Pain Relevance 0.49

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