INT69993

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Context Info
Confidence 0.55
First Reported 1997
Last Reported 2011
Negated 1
Speculated 5
Reported most in Abstract
Documents 93
Total Number 99
Disease Relevance 69.40
Pain Relevance 22.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)
Anatomy Link Frequency
muscle tissue 10
fibroblasts 7
spinal 6
neuronal 6
spinal cord 4
Cpox (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 486 100.00 Very High Very High Very High
dorsal root ganglion 282 100.00 Very High Very High Very High
chemokine 66 100.00 Very High Very High Very High
Inflammatory stimuli 49 99.98 Very High Very High Very High
Peripheral nerve injury 39 99.98 Very High Very High Very High
qutenza 18 99.96 Very High Very High Very High
Inflammation 1085 99.84 Very High Very High Very High
cINOD 502 99.68 Very High Very High Very High
Spinal cord 30 99.68 Very High Very High Very High
Thermal hyperalgesia 26 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 285 100.00 Very High Very High Very High
Injury 308 99.98 Very High Very High Very High
Nervous System Injury 174 99.98 Very High Very High Very High
Cancer 1833 99.96 Very High Very High Very High
Colon Cancer 374 99.96 Very High Very High Very High
Disease 896 99.92 Very High Very High Very High
Renal Cancer 55 99.92 Very High Very High Very High
Pancreatic Cancer 459 99.90 Very High Very High Very High
Targeted Disruption 426 99.88 Very High Very High Very High
INFLAMMATION 1366 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To clarify the roles of cyclooxygenase (COX) in malignant tumor development and angiogenesis, we investigated the effects of COX inhibitors on two kinds of gastrointestinal cancer xenograft, one of which overexpresses COX-2 and the other expresses no COX, in nude mice in vivo.
Positive_regulation (overexpresses) of Gene_expression (overexpresses) of COX associated with malignant neoplastic disease and gastrointestinal neoplasms
1) Confidence 0.55 Published 1999 Journal Lab. Invest. Section Abstract Doc Link 10616198 Disease Relevance 0.64 Pain Relevance 0.03
COX-1 is constitutively expressed, whereas COX-2 is induced by proinflammatory stimuli.
Positive_regulation (induced) of Gene_expression (expressed) of COX
2) Confidence 0.47 Published 1999 Journal Anal. Biochem. Section Abstract Doc Link 10361000 Disease Relevance 0.15 Pain Relevance 0.26
Oral administration with a specific COX-2 or a nonspecific COX inhibitors lowered the expression of potent angiogenic factors; vascular endothelial growth factor and basic fibroblast growth factor, reduced angiogenesis and growth, induced apoptosis, and suppressed cell replication of the COX-2 overexpressing cancer xenografts in a dose-dependent manner.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of COX in fibroblast associated with cancer and apoptosis
3) Confidence 0.39 Published 1999 Journal Lab. Invest. Section Abstract Doc Link 10616198 Disease Relevance 0.82 Pain Relevance 0.10
Estrogen increases expression of COX-2 and production of prostacyclin I2, effects that have been proposed to underlie its apparent cardioprotective effects in animal models [28].
Positive_regulation (increases) of Gene_expression (expression) of COX
4) Confidence 0.35 Published 2006 Journal PLoS Clinical Trials Section Body Doc Link PMC1584256 Disease Relevance 0.28 Pain Relevance 0.31
Cyclooxygenase (COX) enzyme expression is elevated in human and rodent lung tumors, and non-steroidal anti-inflammatory drugs (NSAIDs) such as indomethacin reduce lung tumor formation in mice.
Positive_regulation (elevated) of Gene_expression (expression) of COX in lung associated with inflammation, lung cancer and cinod
5) Confidence 0.32 Published 2002 Journal Carcinogenesis Section Abstract Doc Link 12376474 Disease Relevance 0.58 Pain Relevance 0.35
Induction of COX-2 expression and enzymatic activity promotes neuronal injury in a number of models of neurological disease.
Positive_regulation (Induction) of Gene_expression (expression) of COX in neuronal associated with neurological disease and injury
6) Confidence 0.28 Published 2007 Journal J. Mol. Neurosci. Section Abstract Doc Link 17901552 Disease Relevance 1.02 Pain Relevance 0.24
Whereas COX-1 is normally expressed in many tissues, expression of COX-2 can be induced in response to inflammation.
Positive_regulation (induced) of Gene_expression (expression) of COX associated with inflammation
7) Confidence 0.28 Published 1997 Journal Lakartidningen Section Abstract Doc Link 9190460 Disease Relevance 0.51 Pain Relevance 0.49
In the present study, we investigated the effects of methanolic extracts of CB and DC on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced COX-2 expression in mouse skin.
Positive_regulation (induced) of Gene_expression (expression) of COX in skin
8) Confidence 0.26 Published 2005 Journal Cancer Lett. Section Abstract Doc Link 15639337 Disease Relevance 0.44 Pain Relevance 0.22
In both types of mice induction of thermal hyperalgesia was accompanied by similar increases in COX-1 and COX-2 mRNA expression.
Positive_regulation (increases) of Gene_expression (expression) of COX associated with thermal hyperalgesia
9) Confidence 0.25 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10964977 Disease Relevance 0.43 Pain Relevance 0.51
In both types of mice induction of thermal hyperalgesia was accompanied by similar increases in COX-1 and COX-2 mRNA expression.
Positive_regulation (increases) of Gene_expression (expression) of COX associated with thermal hyperalgesia
10) Confidence 0.25 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10964977 Disease Relevance 0.43 Pain Relevance 0.51
The stimulation of PG production by NO therefore involves an increase in enzymatic activity, rather than an alteration of COX gene expression.
Positive_regulation (alteration) of Gene_expression (expression) of COX gene
11) Confidence 0.25 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10964977 Disease Relevance 0.36 Pain Relevance 0.49
We found that the expression of both COX isoforms is increased by treatment with PGs and that this autoregulation occurs via PG receptors linked to a cAMP signaling pathway.
Positive_regulation (increased) of Gene_expression (expression) of COX
12) Confidence 0.23 Published 2002 Journal J. Environ. Pathol. Toxicol. Oncol. Section Abstract Doc Link 12086405 Disease Relevance 0.26 Pain Relevance 0
We found that overexpression of COX-2 in tumors maybe caused by a dysregulation in the expression pattern of the CCAAT/enhancer binding protein (C/EBP) family of transcription factors.
Positive_regulation (overexpression) of Gene_expression (overexpression) of COX associated with cancer
13) Confidence 0.23 Published 2002 Journal J. Environ. Pathol. Toxicol. Oncol. Section Abstract Doc Link 12086405 Disease Relevance 0.52 Pain Relevance 0.15
We next investigated cis- and transacting factors required for COX-2 expression.
Spec (investigated) Positive_regulation (required) of Spec (investigated) Gene_expression (expression) of COX
14) Confidence 0.23 Published 2002 Journal J. Environ. Pathol. Toxicol. Oncol. Section Abstract Doc Link 12086405 Disease Relevance 0.40 Pain Relevance 0.08
It is widely accepted that peripheral injury increases spinal inducible cyclooxygenase (COX-2) expression and prostaglandin E(2) (PGE(2)) formation as key mediators of nociceptive sensitization.
Positive_regulation (increases) of Gene_expression (expression) of COX in spinal associated with nociception and injury
15) Confidence 0.22 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10964977 Disease Relevance 0.49 Pain Relevance 0.22
It is widely accepted that peripheral injury increases spinal inducible cyclooxygenase (COX-2) expression and prostaglandin E(2) (PGE(2)) formation as key mediators of nociceptive sensitization.
Positive_regulation (inducible) of Gene_expression (expression) of COX in spinal associated with nociception and injury
16) Confidence 0.22 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10964977 Disease Relevance 0.49 Pain Relevance 0.22
Ceramide has been shown to induce, by itself, and also augment, LPS-stimulated COX-2 expression and PGE2 production.
Positive_regulation (augment) of Gene_expression (expression) of COX
17) Confidence 0.21 Published 2004 Journal Brain Behav. Immun. Section Abstract Doc Link 15331118 Disease Relevance 0.25 Pain Relevance 0.06
The aqueous extract of corni fructus suppressed PGE(2) synthesis and NO production by inhibiting the lipopolysaccharide-induced expression of cyclooxygenase (COX)-2 and inducible NO synthase (iNOS) in murine RAW 264.7 macrophage cells.
Positive_regulation (induced) of Gene_expression (expression) of COX in macrophage
18) Confidence 0.21 Published 2009 Journal J Med Food Section Abstract Doc Link 19735178 Disease Relevance 0.30 Pain Relevance 0.55
It is unclear whether increased expression of HADH2 in COX-2-/- mice, as observed in the present study, contributed to those previous findings, but it is interesting that mice overexpressing HADH2 and COX-2-/- mice are both resistant to the aforementioned nervous system insults.


Positive_regulation (overexpressing) of Gene_expression (overexpressing) of COX in nervous system
19) Confidence 0.21 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.44 Pain Relevance 0.08
It is unclear whether increased expression of HADH2 in COX-2-/- mice, as observed in the present study, contributed to those previous findings, but it is interesting that mice overexpressing HADH2 and COX-2-/- mice are both resistant to the aforementioned nervous system insults.


Spec (whether) Positive_regulation (increased) of Spec (whether) Gene_expression (expression) of COX in nervous system
20) Confidence 0.21 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.47 Pain Relevance 0.07

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