INT7000

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Context Info
Confidence 0.67
First Reported 1983
Last Reported 2007
Negated 1
Speculated 3
Reported most in Abstract
Documents 42
Total Number 45
Disease Relevance 9.48
Pain Relevance 18.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Htr2a) cell death (Htr2a) aging (Htr2a)
plasma membrane (Htr2a) response to stress (Htr2a) cytoplasm (Htr2a)
Anatomy Link Frequency
PVN 4
brain 3
spinal cord 2
neurons 2
striatum 1
Htr2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 45 100.00 Very High Very High Very High
anesthesia 7 100.00 Very High Very High Very High
Dopamine 3 100.00 Very High Very High Very High
nociceptor 2 100.00 Very High Very High Very High
fluoxetine 59 99.92 Very High Very High Very High
amygdala 3 99.84 Very High Very High Very High
5HT 5 99.80 Very High Very High Very High
MU agonist 3 99.56 Very High Very High Very High
Morphine 9 99.50 Very High Very High Very High
Glutamate 5 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 28 99.50 Very High Very High Very High
Nociception 17 99.20 Very High Very High Very High
Heat Stroke 14 99.08 Very High Very High Very High
Cv General 4 Under Development 4 99.00 Very High Very High Very High
Shock 6 98.56 Very High Very High Very High
Urological Neuroanatomy 15 98.32 Very High Very High Very High
Anxiety Disorder 10 97.04 Very High Very High Very High
Myoclonus 4 96.72 Very High Very High Very High
Depression 9 95.76 Very High Very High Very High
Cv Unclassified Under Development 4 93.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of 5-HT2 receptors inhibits the evoked release of [3H]noradrenaline in the rat spinal cord.
Positive_regulation (Activation) of 5-HT2 in spinal cord associated with noradrenaline and spinal cord
1) Confidence 0.67 Published 1992 Journal Gen. Pharmacol. Section Title Doc Link 1336746 Disease Relevance 0 Pain Relevance 0.56
Northern blot analysis demonstrated that 5-HT2 receptor mRNA occurs as two bands (approximately 5 and 6 kb in size), both of which were increased by chronic ECS treatment.
Positive_regulation (occurs) of 5-HT2 in bands associated with convulsion
2) Confidence 0.67 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8376984 Disease Relevance 0.80 Pain Relevance 0.29
The effective concentration of DOI, however, was higher than that needed for activation of 5-HT2 receptors, and Northern analysis using a cDNA probe encoding the rat 5-HT2 receptor failed to reveal the presence of 5-HT2 mRNA in myenteric ganglia, although it hybridizes with mRNA of the right size in the guinea pig brain.
Positive_regulation (activation) of 5-HT2 in brain
3) Confidence 0.67 Published 1993 Journal Synapse Section Abstract Doc Link 8386861 Disease Relevance 0 Pain Relevance 0.37
We conclude that serotonin enhances N-methyl-D-aspartate depolarization of rat cortical neurons through activation of 5-HT2 receptors, however the cellular mechanism underlying the facilitation remains to be established.
Positive_regulation (activation) of 5-HT2 in neurons associated with serotonin
4) Confidence 0.67 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8449227 Disease Relevance 0 Pain Relevance 0.36
Activation of 5-HT2 receptors facilitates depolarization of neocortical neurons by N-methyl-D-aspartate.
Positive_regulation (Activation) of 5-HT2 in neurons
5) Confidence 0.67 Published 1993 Journal Eur. J. Pharmacol. Section Title Doc Link 8449227 Disease Relevance 0 Pain Relevance 0.34
Activation of central 5HT2A receptors reduces the craniofacial nociception of rats.
Positive_regulation (Activation) of 5HT2A associated with nociception and nociceptor
6) Confidence 0.67 Published 2007 Journal Neuroscience Section Title Doc Link 17582689 Disease Relevance 0.44 Pain Relevance 0.30
Stimulation of 5-HT2 receptors in the nucleus tractus solitarius enhances NMDA receptor-mediated reflex-evoked bradycardiac responses in the rat.
Positive_regulation (Stimulation) of 5-HT2 in nucleus associated with anesthesia and nmda receptor
7) Confidence 0.67 Published 2001 Journal Auton Neurosci Section Title Doc Link 11570703 Disease Relevance 0.24 Pain Relevance 0.29
Stimulation of both NMDA and 5-HT2A/2C receptors had a mutually potentiating effect.
Positive_regulation (Stimulation) of 5-HT2A
8) Confidence 0.67 Published 1997 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9077592 Disease Relevance 0.84 Pain Relevance 0.54
These findings suggest that operant ethanol self-administration can be suppressed in a specific manner by activation of 5-HT2A and, possibly, 5-HT2C receptors, and in a nonselective manner by activation of 5-HT1B receptors.
Spec (possibly) Positive_regulation (activation) of 5-HT2A
9) Confidence 0.67 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10334495 Disease Relevance 0 Pain Relevance 0.39
Although the results suggest that selective stimulation of 5-HT1A and 5-HT2A receptors produces a decrease of USV, we postulate that only 5-HT2A receptors play a pivotal role in the effects of SSRIs in this model of anxiety.
Positive_regulation (stimulation) of 5-HT2A associated with anxiety disorder and ssri
10) Confidence 0.67 Published 1998 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9539263 Disease Relevance 0.38 Pain Relevance 0.36
We evaluated whether the anxiolytic effects of selective serotonin reuptake inhibitors (SSRIs) in the rat ultrasonic vocalization (USV) test are preferentially mediated by (indirect) activation of 5-HT1A, 5-HT1B/1D, 5-HT2A, 5-HT3 or 5-HT4 receptors.
Positive_regulation (activation) of 5-HT2A associated with anxiety disorder and ssri
11) Confidence 0.67 Published 1998 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9539263 Disease Relevance 0.26 Pain Relevance 0.44
Chronic (10 or 14 days), but not acute (1 or 3 days), ECS treatment significantly increased levels of 5-HT2 receptor mRNA.
Positive_regulation (increased) of 5-HT2 associated with convulsion
12) Confidence 0.67 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8376984 Disease Relevance 0.84 Pain Relevance 0.27
Progesterone alone caused a smaller increase in 5HT2 receptors, a similar decrease in 5HT1 and had no significant effect on noradrenergic receptors.
Positive_regulation (increase) of 5HT2
13) Confidence 0.67 Published 1983 Journal Life Sci. Section Abstract Doc Link 6188018 Disease Relevance 0 Pain Relevance 0.11
The results support earlier evidence that serum corticosterone concentration in rats can be increased by activation of either 5-HT1A or 5-HT2 receptors.
Positive_regulation (activation) of 5-HT2
14) Confidence 0.67 Published 1990 Journal Neuroendocrinology Section Abstract Doc Link 2148812 Disease Relevance 0 Pain Relevance 0.68
Estrogen treatment resulted in a decrease in the number of 5HT1 and beta adrenergic receptors, with a concomitant increase in 5HT2 receptors.
Positive_regulation (increase) of 5HT2
15) Confidence 0.67 Published 1983 Journal Life Sci. Section Abstract Doc Link 6188018 Disease Relevance 0 Pain Relevance 0.03
The present results strongly suggest that previous activation of 5-HT1A receptors or antagonism of 5-HT2A receptors protects against heatstroke by reducing circulatory shock and cerebral ischemia, whereas prior antagonism of 5-HT1A receptors or activation of 5-HT2A receptors exacerbates heatstroke.
Positive_regulation (activation) of 5-HT2A associated with heat stroke, cv general 4 under development, ischemia and shock
16) Confidence 0.67 Published 2005 Journal Shock Section Abstract Doc Link 16205318 Disease Relevance 1.37 Pain Relevance 0.30
Fluoxetine treatment also resulted in upregulation of 5-HT2 receptors in layers of frontoparietal cortex (31-38%) and in CA2-3 fields of hippocampus (by 39%).
Positive_regulation (upregulation) of 5-HT2 in cortex associated with hippocampus and fluoxetine
17) Confidence 0.67 Published 1993 Journal Synapse Section Abstract Doc Link 8248854 Disease Relevance 0.07 Pain Relevance 0.67
Chronic fluoxetine treatment upregulates 5-HT uptake sites and 5-HT2 receptors in rat brain: an autoradiographic study.
Positive_regulation (upregulates) of 5-HT2 in brain associated with fluoxetine
18) Confidence 0.67 Published 1993 Journal Synapse Section Title Doc Link 8248854 Disease Relevance 0.09 Pain Relevance 0.56
In addition, activation of the serotonin2A receptor selectively enhances late components of electrically evoked excitatory postsynaptic currents.
Positive_regulation (activation) of serotonin2A receptor
19) Confidence 0.50 Published 2001 Journal Neuroscience Section Abstract Doc Link 11483300 Disease Relevance 0 Pain Relevance 0.44
The results obtained indicate that: (a) activation of 5-HT1A receptors stimulated PRL secretion on day 16 and inhibited it on day 23; activation of 5-HT2 receptors stimulated PRL secretion on days 16 and 23, whereas activation of 5-HT3 receptors inhibited PRL release only on day 23; (b) activation of AMPA receptors inhibited PRL secretion on day 23, but not on day 16 and (c) a cross-talk is apparent between 5-HT2 and AMPA receptors in the regulation of PRL secretion, the stimulatory effect of DOI being blocked by AMPA.
Positive_regulation (activation) of 5-HT2
20) Confidence 0.49 Published 2001 Journal J. Physiol. Biochem. Section Abstract Doc Link 11800286 Disease Relevance 0 Pain Relevance 0.45

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