INT70015

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Context Info
Confidence 0.64
First Reported 1997
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk)
Anatomy Link Frequency
Cleavage 1
striatum 1
brain 1
Penk (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 6 100.00 Very High Very High Very High
Nicotine 7 98.54 Very High Very High Very High
medulla 2 96.80 Very High Very High Very High
Peripheral nervous system 1 94.00 High High
Neurotransmitter 1 84.08 Quite High
antagonist 1 77.20 Quite High
Dopamine 1 76.00 Quite High
Glutamate receptor 1 75.00 Quite High
Glutamate 3 72.72 Quite High
gABA 3 65.92 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the guinea-pig brain, preproenkephalin mRNA transcripts are cleaved at a specific site located in the 3' untranslated region.
Protein_catabolism (cleaved) of preproenkephalin in brain
1) Confidence 0.64 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9191091 Disease Relevance 0 Pain Relevance 0.13
A single dose of nicotine given to mice induces first a rapid decrease (presumed release/enhanced degradation) and then a rise (presumed synthesis/enhanced accumulation) of met-enkephalin (Met-Enk) in dorsal and ventral striatum observed at 30 and 60 min post-treatment, respectively.
Protein_catabolism (degradation) of Met-Enk in striatum associated with nicotine and enkephalin
2) Confidence 0.50 Published 2000 Journal Brain Res. Section Abstract Doc Link 10996137 Disease Relevance 0 Pain Relevance 0.72
Cleavage of recombinant proenkephalin and blockade mutants by prohormone convertases 1 and 2: an in vitro specificity study.
Protein_catabolism (Cleavage) of proenkephalin in Cleavage associated with enkephalin
3) Confidence 0.10 Published 2003 Journal J. Neurochem. Section Title Doc Link 14622118 Disease Relevance 0 Pain Relevance 0.26

General Comments

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