INT70017

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 1997
Last Reported 2011
Negated 3
Speculated 0
Reported most in Body
Documents 87
Total Number 87
Disease Relevance 66.62
Pain Relevance 8.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BCL2) cell morphogenesis (BCL2) endoplasmic reticulum (BCL2)
intracellular (BCL2) cytoplasm (BCL2) cytosol (BCL2)
Anatomy Link Frequency
HL-60 2
RPE 2
smooth muscle 1
brain 1
fibroblast 1
BCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 77 99.54 Very High Very High Very High
Analgesic 10 99.48 Very High Very High Very High
thoracic epidural anesthesia 4 98.80 Very High Very High Very High
qutenza 17 98.56 Very High Very High Very High
Dismenorea 5 98.52 Very High Very High Very High
anesthesia 8 98.12 Very High Very High Very High
fibrosis 36 98.04 Very High Very High Very High
opiate 14 97.88 Very High Very High Very High
potassium channel 3 97.40 Very High Very High Very High
Kinase C 38 97.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 3126 100.00 Very High Very High Very High
Leukemia 71 99.92 Very High Very High Very High
Cancer 1538 99.68 Very High Very High Very High
Shock 10 99.66 Very High Very High Very High
Myocardial Infarction 100 99.64 Very High Very High Very High
Death 424 99.52 Very High Very High Very High
Injury 64 99.42 Very High Very High Very High
Stomach Cancer 57 99.40 Very High Very High Very High
Urological Neuroanatomy 2 99.40 Very High Very High Very High
Disease 332 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
General anesthesia with thoracic epidural anesthesia in the cardiopulmonary bypass surgery reduces apoptosis by upregulating antiapoptotic protein Bcl-2.
Positive_regulation (upregulating) of Bcl-2 in thoracic associated with anesthesia, thoracic epidural anesthesia and apoptosis
1) Confidence 0.67 Published 2006 Journal J Cardiovasc Surg (Torino) Section Title Doc Link 16760868 Disease Relevance 0.10 Pain Relevance 0.34
RESULTS: In the TEA+GA group, the Bcl-2 positive cardiomyocytes were distinctly statistically increased compared to the GA group (P<0.001).
Positive_regulation (increased) of Bcl-2 in cardiomyocytes
2) Confidence 0.67 Published 2006 Journal J Cardiovasc Surg (Torino) Section Body Doc Link 16760868 Disease Relevance 0.15 Pain Relevance 0
After 4 degrees C storage and warm reperfusion, MEGX production was preserved in 24 h- and 48 h-stored bioreactors as well as a sharp increase of Bcl-2 and a decrease of Bax mRNAs.
Positive_regulation (increase) of Bcl-2 associated with apoptosis
3) Confidence 0.63 Published 2003 Journal Int J Artif Organs Section Abstract Doc Link 12653348 Disease Relevance 0.58 Pain Relevance 0.07
Additionally, U69593 increased the content of the anti-apoptotic members of the Bcl-2 family of proteins, the Bcl-2 and Bcl-x(L), whereas it had no significant effect on the apoptosis-promoting homologues Bax, Bcl-x(S) and Bak.
Positive_regulation (increased) of Bcl-2 associated with apoptosis
4) Confidence 0.57 Published 2001 Journal Mol. Hum. Reprod. Section Abstract Doc Link 11517294 Disease Relevance 0.92 Pain Relevance 0.64
These data support the idea that endomorphins induce apoptosis in HL-60 cells through the activation of the Bcl-2-Bax and the Fas-FasL pathway.
Positive_regulation (activation) of Bcl-2-Bax in HL-60 associated with apoptosis
5) Confidence 0.57 Published 2004 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 15644942 Disease Relevance 0.62 Pain Relevance 0.21
On immunohistochemistry they were found to be positive for Bcl2, CD20, CD45RB and CD79a, but negative for CD3, CD5, CD10 and cyclin D1.
Positive_regulation (positive) of Bcl2
6) Confidence 0.54 Published 2008 Journal Pathol. Int. Section Abstract Doc Link 18324920 Disease Relevance 0.58 Pain Relevance 0.24
Although some authors have described an increase in bcl-2 during the progression of normal melanocytes to melanomas, others have observed the opposite [11-15].
Positive_regulation (increase) of bcl-2 in melanocytes associated with melanoma
7) Confidence 0.49 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2478655 Disease Relevance 1.30 Pain Relevance 0
Results presented here also show increased Bak-1 (a proapoptotic member of the Bcl-2 family) levels, which are required along with Bax to increase MOMP and apoptosis.
Positive_regulation (increased) of Bcl-2 associated with apoptosis
8) Confidence 0.49 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 1.40 Pain Relevance 0.03
Yet, recent evidence favors a central role for vBcl-2s of ?
Positive_regulation (role) of Bcl-2
9) Confidence 0.49 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752191 Disease Relevance 0.49 Pain Relevance 0
In addition, to evaluate the Bcl-2/Bax status during the menstrual cycle in these tissues.
Positive_regulation (evaluate) of Bcl-2
10) Confidence 0.48 Published 2001 Journal Eur. J. Obstet. Gynecol. Reprod. Biol. Section Abstract Doc Link 11788183 Disease Relevance 0.35 Pain Relevance 0.17
Moreover, the finding that tissue injury is associated with elevated Bcl-2 activation could open up new diagnostic possibilities and therapeutic strategies to prevent tissue destruction in periodontal disease.


Positive_regulation (activation) of Bcl-2 associated with injury and periodontal disease
11) Confidence 0.47 Published 2006 Journal Head Face Med Section Body Doc Link PMC1524725 Disease Relevance 1.27 Pain Relevance 0.15
By contrast, the antiapoptotic bcl-2 RNA levels increased in the group after marathon (Figure 2B) (Table 1).
Positive_regulation (increased) of bcl-2 RNA
12) Confidence 0.46 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0.15 Pain Relevance 0
We have shown that RNA levels of proapoptotic bax were consistently decreased after marathon, whereas, RNA levels of antiapoptotic bcl-2 were slightly increased after marathon thereby causing a decreased bax: bcl-2 ratio (Figure 2B, C).
Positive_regulation (increased) of bcl-2
13) Confidence 0.46 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0.59 Pain Relevance 0
JNK activation has also been implicated in FFA-induced hepatocyte lipoapoptosis by activation of proapoptotic BCL-2 proteins Bim and Bax, triggering the mitochondrial apoptotic pathway [4, 67].
Positive_regulation (activation) of BCL-2 in hepatocyte associated with apoptosis
14) Confidence 0.45 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.93 Pain Relevance 0.03
affected cell proliferation by inducing expression of p21, and cell death by influencing various Bcl-2 family proteins and caspase-3 activation.
Positive_regulation (activation) of Bcl-2 associated with death
15) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885411 Disease Relevance 0.30 Pain Relevance 0.05
We report here that various NSAIDs, including celecoxib, up-regulate PUMA, a Bcl-2 family protein with potent apoptosis-inducing activity, in human gastric carcinoma cell line, accompanying the induction of apoptosis.
Positive_regulation (up-regulate) of Bcl-2 associated with cinod, apoptosis and stomach cancer
16) Confidence 0.45 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17368424 Disease Relevance 0.87 Pain Relevance 0.23
Zhou et al. (18) reported that combined gene therapy using VEGF and Ang-1 significantly reduced myocardial infarct size through the induction of the phosphatidylinositol 3-kinase and Bcl-2 survival pathways and nuclear factor-?
Positive_regulation (induction) of Bcl-2 associated with myocardial infarction
17) Confidence 0.45 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 0.67 Pain Relevance 0.13
Therefore any increase in bcl-2 or decrease in bax will push the balance towards chemo resistance and an increase in bax or decrease in bcl-2 will result in increased apoptosis [26-30].
Positive_regulation (increase) of bcl-2 associated with apoptosis
18) Confidence 0.45 Published 2004 Journal BMC Cancer Section Body Doc Link PMC514705 Disease Relevance 1.39 Pain Relevance 0
In pancreatic ductal adenocarcinoma and ampullary cancer, bcl-2 was not detected compared with expression seen in normal acini (p < 0.01), minor (p < 0.001) and major ducts (p < 0.01), bax expression was reduced with respect to minor ducts (p < 0.01) but no different from normal acini or major ducts. bak and bcl-x were more strongly expressed in malignant epithelia compared with acini and major ducts but reduced when compared with minor ducts (p < 0.01).
Neg (not) Positive_regulation (detected) of bcl-2 in ducts
19) Confidence 0.43 Published 2001 Journal Pancreatology Section Body Doc Link 12120204 Disease Relevance 0.08 Pain Relevance 0
Instead, the chronic modulation of some of their components (downregulation of FADD and cytochrome c; upregulation of FLIP(L) and Bcl-2) suggests the induction of non-apoptotic actions by opiate drugs related to phenomena of synaptic plasticity in the brain.
Positive_regulation (upregulation) of Bcl-2 in brain associated with opiate and apoptosis
20) Confidence 0.42 Published 2008 Journal Neuroscience Section Abstract Doc Link 18834930 Disease Relevance 0.74 Pain Relevance 0.48

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox