INT70018

Context Info Confidence 0.55 First Reported 1997 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.49 Pain Relevance 0.13

cell differentiation (AXL) signal transduction (AXL) plasma membrane (AXL)

AXL (Homo sapiens)

Pain Link Frequency Relevance Heat endometriosis 108 84.76 Thalamus 1 10.36 Analgesic 1 10.00 pain pelvic 2 5.00 cytokine 1 5.00 Inflammation 1 5.00 Dismenorea 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 2 85.00 Endometriosis 138 84.76 Cancer 3 68.40 Ovarian Cancer 15 5.00 Disease 11 5.00 Reprotox - General 3 4 5.00 Carcinoma 3 5.00 Myelodysplastic Syndromes 2 5.00 Malignant Neoplastic Disease 2 5.00 Chromosome Aberrations 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The following primary antibodies were used: AXL (polyclonal, dilution 1:50, Santa Cruz Biotech., Santa Cruz, CA, USA), SHC1 (polyclonal, dilution 1:300, Santa Cruz Biotech.), phospho-Erk1/2 (monoclonal, dilution 1:50 Santa Cruz Biotech.), PI3KCA (polyclonal, dilution 1:50, Abgent, San Diego, CA, USA), phospho-Akt (Ser473) (clone 736E11, dilution 1:50, Cell Signaling Technology, Danvers, MA, USA), phospho-mTOR (Ser 2448) (clone 49F9, dilution 1:50, Cell Signaling Technology).

Localization (phospho) of AXL

1) Confidence 0.55 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 0.41 Pain Relevance 0.13

Moreover cells were processed for the localization of oncogene proteins (bcl-2, TIAR, ICH-1t) associated with apoptosis.

Localization (localization) of oncogene

2) Confidence 0.06 Published 1997 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 9191602 Disease Relevance 0.09 Pain Relevance 0

General Comments

This test has worked.