INT70019

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.47
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 25
Total Number 25
Disease Relevance 17.55
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BCL2) cell morphogenesis (BCL2) endoplasmic reticulum (BCL2)
intracellular (BCL2) cytoplasm (BCL2) cytosol (BCL2)
Anatomy Link Frequency
smooth muscle 1
pore 1
BCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 26 98.96 Very High Very High Very High
Pain 9 90.56 High High
cINOD 40 85.88 High High
Inflammation 97 82.32 Quite High
Central nervous system 8 74.80 Quite High
Spinal cord 6 66.56 Quite High
ischemia 22 61.92 Quite High
chemokine 13 56.96 Quite High
Catecholamine 2 51.04 Quite High
cytokine 42 47.84 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 1105 100.00 Very High Very High Very High
Stomach Cancer 52 99.20 Very High Very High Very High
Periodontitis 25 98.96 Very High Very High Very High
Breast Cancer 214 98.92 Very High Very High Very High
Stress 98 98.08 Very High Very High Very High
Necrosis 29 97.88 Very High Very High Very High
Lymphatic System Cancer 142 97.52 Very High Very High Very High
Parkinson's Disease 14 97.32 Very High Very High Very High
Skin Cancer 48 96.98 Very High Very High Very High
Cancer 869 93.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hyper-activation of CaN reduces the phosphorylation of BAD [18], which then disassociate from the scaffolding protein 14-3-3 and interacts with Bcl-Lx or other Bcl2 family proteins located in the mitochondrial membrane.
Bcl2 Binding (interacts) of
1) Confidence 0.47 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2951383 Disease Relevance 0.36 Pain Relevance 0
This domain is required for its ability to bind to Bcl-2-like, pro-survival proteins and to initiate apoptosis.
Bcl-2 Binding (bind) of associated with apoptosis
2) Confidence 0.43 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.86 Pain Relevance 0
COS-7 cells were treated as shown for 24 h and blotted for phosphorylated Bcl-2 (PBcl-2) before stripping and reprobing for total Bcl-2 (TBcl-2).
Bcl-2 Binding (reprobing) of
3) Confidence 0.36 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2916709 Disease Relevance 0 Pain Relevance 0
This could be explained in three distinct ways: first, there is no correlation between survival and the immunohistochemical expression of bcl-2 in CM; second, this correlation exists, but was not demonstrated in the present study due to the small sample size and short follow-up time; and third, the interaction between the other members of the BCL-2 family may have neutralized the expression of bcl-2.
BCL-2 Binding (interaction) of associated with skin cancer
4) Confidence 0.35 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2478655 Disease Relevance 0.76 Pain Relevance 0
Interactions between pro- and anti-apoptotic proteins of the Bcl-2 family decide the fate of cells in response to stress signals.
Bcl-2 Binding (Interactions) of associated with stress and apoptosis
5) Confidence 0.35 Published 2009 Journal Neurotox Res Section Body Doc Link PMC3006666 Disease Relevance 0.80 Pain Relevance 0.08
Bik/Nbk BCL2-interacting killer/ natural-born killer
BCL2 Binding (interacting) of
6) Confidence 0.33 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 1.00 Pain Relevance 0.09
BH3 peptides from Bad and Bik cannot directly activate Bax or Bak, but instead bind anti-apoptotic members of BCL-2, resulting in displacement of Bid-like BH3 domains which initiate mitochondrial dysfunction.
BCL-2 Neg (cannot) Binding (bind) of associated with parkinson's disease and apoptosis
7) Confidence 0.33 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.72 Pain Relevance 0
However, mutation of the Bik phosphorylation sites, in which the Thr and Ser residues were changed to alanine residues, reduced the apoptotic activity of Bik protein without significantly affecting its ability to heterodimerize with BCL-2 [44]
BCL-2 Binding (heterodimerize) of associated with apoptosis
8) Confidence 0.32 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 1.06 Pain Relevance 0
One hypothesis is that both pro-apoptotic and anti-apoptotic Bcl-2 proteins bind directly to components of the mitochondrial pore, leading to either its opening or closure, respectively (Gross et al 1999; Mattson and Kroemer 2003).
Bcl-2 Binding (bind) of in pore associated with apoptosis
9) Confidence 0.31 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291307 Disease Relevance 0.86 Pain Relevance 0.06
mRNA encodes the Bax protein, which promotes apoptosis due to its ability to form heterodimers with bcl-2 [24].
bcl-2 Binding (form) of associated with apoptosis
10) Confidence 0.26 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2873331 Disease Relevance 0.78 Pain Relevance 0
However, staining for Bcl-2 was more frequent in the GAP specimens than in the controls.
Bcl-2 Binding (staining) of associated with periodontitis
11) Confidence 0.25 Published 2006 Journal Head Face Med Section Body Doc Link PMC1524725 Disease Relevance 0.93 Pain Relevance 0.06
Thus, the majority of gastric carcinomas (if not all) are immunohistochemically negative for bcl-2.
bcl-2 Binding (negative) of associated with stomach cancer
12) Confidence 0.23 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.03 Pain Relevance 0
Moreover cells were processed for the localization of oncogene proteins (bcl-2, TIAR, ICH-1t) associated with apoptosis.
bcl-2 Binding (associated) of
13) Confidence 0.22 Published 1997 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 9191602 Disease Relevance 0.08 Pain Relevance 0
These cells were strongly immunoreactive with CD34, Bcl-2, CD99, and vimentin, but were negative with S100 protein, smooth muscle actin, and epithelial membrane antigen.
Bcl-2 Binding (immunoreactive) of in smooth muscle
14) Confidence 0.20 Published 2004 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 14987150 Disease Relevance 0.83 Pain Relevance 0.12
This positive association of bcl-2 with hormone receptors in breast cancer may explain its apparent correlation with response to hormonal therapy.
bcl-2 Binding (association) of associated with breast cancer
15) Confidence 0.15 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 1.17 Pain Relevance 0
In this view, the interaction between Bcl-2 family pro- and antiapoptotic members represents a crucial and delicate step.
Bcl-2 Binding (interaction) of
16) Confidence 0.12 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.05 Pain Relevance 0
Anti-rabbit Bcl-2, Bid, Bax, cytochrome c, and ?
Bcl-2 Binding (rabbit) of
17) Confidence 0.11 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2987898 Disease Relevance 0.33 Pain Relevance 0
The membrane was then probed with primary antibodies to Bcl-2, Bax, Bid, cytochrome c, caspase-3, -8, -9, PARP and ?
Bcl-2 Binding (antibodies) of
18) Confidence 0.11 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2987898 Disease Relevance 0 Pain Relevance 0
The interaction between Bax/Bak and the Bcl-2 family anti-apoptotic members is carefully regulated by the BH-3-only proteins.
Bcl-2 Binding (interaction) of associated with apoptosis
19) Confidence 0.09 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.07 Pain Relevance 0
Antagonizing this reaction are the BH3-only proteins, which promote apoptosis by displacing Bax and Bak bound to the Bcl-2 proteins.
Bcl-2 Binding (bound) of associated with apoptosis
20) Confidence 0.05 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 0.91 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox