INT70021

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Context Info
Confidence 0.74
First Reported 1997
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 23
Total Number 24
Disease Relevance 21.60
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BCL2) cell morphogenesis (BCL2) endoplasmic reticulum (BCL2)
intracellular (BCL2) cytoplasm (BCL2) cytosol (BCL2)
Anatomy Link Frequency
nucleus 2
SiHa 1
follicles 1
HeLa 1
cleavage 1
BCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 8 94.40 High High
imagery 9 85.20 High High
ischemia 28 79.12 Quite High
Pain 27 75.00 Quite High
Inflammation 89 72.96 Quite High
dexamethasone 63 71.92 Quite High
Dismenorea 1 64.96 Quite High
palliative 5 57.40 Quite High
Osteoarthritis 43 56.16 Quite High
local anesthetic 1 55.60 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 1026 100.00 Very High Very High Very High
Epstein-barr Virus 30 99.68 Very High Very High Very High
Cancer 604 99.66 Very High Very High Very High
Precursor Cell Lymphoblastic Leukemia-lymphoma 4 98.64 Very High Very High Very High
Death 202 97.88 Very High Very High Very High
Mantle-cell Lymphoma 33 96.72 Very High Very High Very High
Diffuse Large B-cell Lymphoma 56 96.08 Very High Very High Very High
Cervical Cancer 4 95.92 Very High Very High Very High
Cyst 12 94.96 High High
Thyroid Nodule 2 94.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also, we did not analyze the relationship between location of the primary lesion, survival and bcl-2.
Spec (analyze) Localization (location) of bcl-2
1) Confidence 0.74 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2478655 Disease Relevance 1.01 Pain Relevance 0
The samples were positive for anti-BCL-2, CD10, CD20 and CD68 antibodies and negative for CD3 (in the follicles).
Neg (negative) Localization (negative) of BCL-2 in follicles
2) Confidence 0.73 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862671 Disease Relevance 0.89 Pain Relevance 0.15
Bcl-xL is a member of the Bcl-2 family that acts on the mitochondrial membrane to prevent release of caspase activators such as cytochrome-C [27].
Localization (release) of Bcl-2
3) Confidence 0.73 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 1.19 Pain Relevance 0
The antigens tested by immunohistochemistry were: pan-keratin, keratin Cam 5.2, cytokeratin 7, cytokeratin 10, cytokeratin 18, cytokeratin 20, epithelial membrane antigen, vimentin, desmin, actin, myosin, CD34, CD68, CD99, CD117, S-100 protein, and bcl-2.
Localization (desmin) of bcl-2
4) Confidence 0.73 Published 2007 Journal Virchows Arch Section Body Doc Link PMC2039817 Disease Relevance 0.50 Pain Relevance 0
Meanwhile, Yamaguchi et al. show that proapoptotic Bcl-2 family members promote cytochrome c mobilization through Opa1-mediated cristae remodeling.
Localization (mobilization) of Bcl-2
5) Confidence 0.73 Published 2008 Journal Dev. Cell Section Abstract Doc Link 18804432 Disease Relevance 0.17 Pain Relevance 0.07
Ectopic overexpression of the secreted form of clusterin/apoliporotein J or Bcl-2 decreased the sensitivity of HaCaT cells to toxic effects of ropivacaine as demonstrated by DNA fragmentation, the proteolytic cleavage of PARP and by a reduction in procaspase-3 expression.
Localization (secreted) of Bcl-2 in cleavage
6) Confidence 0.64 Published 2004 Journal Cell Res. Section Abstract Doc Link 15538973 Disease Relevance 0.91 Pain Relevance 0.13
There was positive correlation between the expression rates of COX-2 and bcl-2 in pancreatic carcinoma.
Localization (rates) of bcl-2
7) Confidence 0.57 Published 2003 Journal Ai Zheng Section Body Doc Link 12948419 Disease Relevance 0.08 Pain Relevance 0
Bcl-2 and Bax localize at the outer membrane of mitochondrial.
Localization (localize) of Bcl-2
8) Confidence 0.51 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2924280 Disease Relevance 0.84 Pain Relevance 0
Preconditioning causes a decrease in pro-apoptotic Bax and increase in the anti-apoptotic Bcl-2 proteins resulting in an altered Bcl-2/Bax ratio and attenuation of cytochrome c release from mitochondria (Maulik et al 1999, 2000; Nakamura et al 2000).
Localization (release) of Bcl-2 associated with apoptosis
9) Confidence 0.48 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291307 Disease Relevance 1.23 Pain Relevance 0.15
(ER), progesterone receptor (PgR), proliferation marker (ki-67), tumor suppressor p53, regulator of apoptosis Bcl2, protooncogene cerbB2/HER2neu, epidermal growth factor receptor (EGFR) were assessed according to routine bio- and/or immunohistochemical methods.
Localization (regulator) of Bcl2 associated with cancer and apoptosis
10) Confidence 0.47 Published 2005 Journal J Transl Med Section Body Doc Link PMC1201176 Disease Relevance 0.52 Pain Relevance 0
Moreover cells were processed for the localization of oncogene proteins (bcl-2, TIAR, ICH-1t) associated with apoptosis.
Localization (localization) of bcl-2
11) Confidence 0.47 Published 1997 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 9191602 Disease Relevance 0.09 Pain Relevance 0
Exercise and bcl-2 pathway apoptotic signaling
Localization (apoptotic) of bcl-2 associated with apoptosis
12) Confidence 0.43 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0.23 Pain Relevance 0
The antibodies against caspase3, caspase8, caspase9, DR5, Bcl-2, Bax and ?
Localization (caspase9) of Bcl-2
13) Confidence 0.37 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2941086 Disease Relevance 0 Pain Relevance 0
This is not undisputed, because it has also been shown in another study that zinc can increase the expression of Bax, leading to an decreased Bcl-2/Bax ratio and the release of cytochrome-c from mitochondria [101].
Localization (release) of Bcl-2
14) Confidence 0.24 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872358 Disease Relevance 0.84 Pain Relevance 0
Mitochondria play critical roles in the regulation of various apoptotic processes including drug-induced apoptosis[16].The mitochondrial death pathway is controlled by members of the Bcl-2 family, which play a central regulatory role to decide the fate of the cells via the interaction between pro- and anti-apoptotic members[17,18].The Bcl-2 family consists of pro-apoptotic and anti-apoptotic members[19].During apoptosis, Bcl-2 family pro-apoptotic proteins including Bim, Bax and Bid can translocate to the outer membrane of mitochondria, promote the release of pro-apoptotic factors, and induce apoptosis.
Localization (translocate) of Bcl-2 associated with apoptosis and death
15) Confidence 0.22 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2987898 Disease Relevance 2.54 Pain Relevance 0
The pro-apoptotic (e.g., Bax, Bcl-xS) and anti-apoptotic (e.g., Bcl-2, Bcl-xL) members of this family, respectively, promote and inhibit the translocation of cytochrome c from mitochondria to cytosol [15].
Localization (translocation) of Bcl-2 associated with apoptosis
16) Confidence 0.20 Published 2004 Journal Mol Cancer Section Body Doc Link PMC544397 Disease Relevance 1.41 Pain Relevance 0.24
Curcumin-mediated apoptosis in these cells is initiated by up-regulation of pro-apoptotic Bax, AIF, release of cytochrome c, and downregulation of anti-apoptotic Bcl-2, Bcl-xL in HeLa and SiHa cell lines.
Localization (release) of Bcl-2 in HeLa associated with apoptosis
17) Confidence 0.18 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.22 Pain Relevance 0
Our findings reveal that OGE pretreatment increased the level of Bcl-2, suggesting that OGE's protective effects consists of the inhibition of the CytC release and apoptosome formation, resulting in the inhibition of mitochondrial pathway activation.
Localization (release) of Bcl-2
18) Confidence 0.16 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952314 Disease Relevance 0.47 Pain Relevance 0
In contrast to Bcl-2, Mcl-1 is not only found in mitochondrial membranes, but also in the nucleus and cytoplasm [11].
Localization (found) of Bcl-2 in nucleus
19) Confidence 0.11 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.90 Pain Relevance 0.06
mol/l induced increased expression of Bax in the MDA-MB-231 cells (Fig. 3c), but no significant decrease in Bcl-2 was observed (data not shown).
Localization (decrease) of Bcl-2 in MDA-MB-231
20) Confidence 0.10 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1175053 Disease Relevance 0.70 Pain Relevance 0

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