INT70025

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Context Info
Confidence 0.27
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.96
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BCL2) cell morphogenesis (BCL2) endoplasmic reticulum (BCL2)
intracellular (BCL2) cytoplasm (BCL2) cytosol (BCL2)
Anatomy Link Frequency
neuronal 2
RPE 2
BCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
bDMF 16 88.96 High High
anticonvulsant 8 88.24 High High
Lamotrigine 23 86.24 High High
Gabapentin 7 85.20 High High
Glutamate 4 64.56 Quite High
Calcium channel 2 61.60 Quite High
gABA 7 43.52 Quite Low
Central nervous system 5 40.08 Quite Low
Hippocampus 4 35.04 Quite Low
Raphe 1 14.84 Low Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 1 99.40 Very High Very High Very High
Death 7 97.44 Very High Very High Very High
Apoptosis 142 97.20 Very High Very High Very High
Lymphatic System Cancer 1 94.00 High High
Stress 2 92.64 High High
Manic Depressive Disorder 125 90.24 High High
Neurodegenerative Disease 4 43.52 Quite Low
Papillomavirus Infection 1 38.16 Quite Low
Cervical Cancer 1 36.64 Quite Low
Repression 4 24.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment of RPE cells in serum-free medium with flupirtine (flupirtine gluconate, 100 microM) for 72 hours caused an upregulation of bcl-2 protein.
Positive_regulation (caused) of Positive_regulation (upregulation) of bcl-2 in RPE
1) Confidence 0.27 Published 1997 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 9191602 Disease Relevance 0 Pain Relevance 0
Finally, the pro-survival BCL2L2 or BCL-W and GLRX2 [78,79] genes, in addition to the induction of BCL2 and CYCS (encodes cytochrome c) that also occurs in WT cells, were induced in WTSTS cells.
Positive_regulation (induced) of Positive_regulation (induction) of BCL2
2) Confidence 0.16 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.32 Pain Relevance 0
It has been shown that administration of both lithium and VPA induces a two-fold increase in bcl-2 levels in the frontal cortex of chronically-treated rodents [127] and in the neuronal cell lines SH-SY5Y [128].
Positive_regulation (induces) of Positive_regulation (increase) of bcl-2 in neuronal associated with urological neuroanatomy
3) Confidence 0.04 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.64 Pain Relevance 0.58

General Comments

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