INT70027

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Context Info
Confidence 0.62
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 7.21
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (C6orf25) endoplasmic reticulum (C6orf25) plasma membrane (C6orf25)
Anatomy Link Frequency
myocardium 4
Cerebrospinal fluid 2
T cell 2
C6orf25 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 59 96.76 Very High Very High Very High
intrathecal 4 95.80 Very High Very High Very High
methotrexate 14 94.20 High High
Inflammation 69 91.84 High High
Sciatica 1 89.92 High High
tolerance 7 87.00 High High
headache 18 83.64 Quite High
corticosteroid 24 57.84 Quite High
cytokine 42 54.72 Quite High
Inflammatory response 2 47.28 Quite Low
Disease Link Frequency Relevance Heat
Leukocytosis 1 100.00 Very High Very High Very High
Coronary Heart Disease 274 99.00 Very High Very High Very High
Thrombocytopenia 2 98.80 Very High Very High Very High
Spinal Cord Diseases 1 98.64 Very High Very High Very High
Granuloma 1 98.28 Very High Very High Very High
Disease 113 98.18 Very High Very High Very High
Bullous Skin Disease 75 98.16 Very High Very High Very High
Blister 8 97.72 Very High Very High Very High
Coagulation Disorder 1 97.24 Very High Very High Very High
Rheumatoid Arthritis 71 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The patient also developed a nonspecific increase in immunoglobulin production.
Positive_regulation (increase) of Gene_expression (production) of immunoglobulin
1) Confidence 0.62 Published 1997 Journal Neurology Section Abstract Doc Link 9191777 Disease Relevance 0.90 Pain Relevance 0.08
Cerebrospinal fluid exam showed elevation of protein, mononuclear pleocytosis and immunoglobulin synthesis.
Positive_regulation (elevation) of Gene_expression (synthesis) of immunoglobulin in Cerebrospinal fluid associated with leukocytosis
2) Confidence 0.46 Published 2008 Journal J. Neurol. Sci. Section Abstract Doc Link 17949753 Disease Relevance 0.88 Pain Relevance 0.43
Patients with anti-IgA antibodies, intolerant of low-IgA IVIg have successfully been transitioned to subcutaneous therapy.20,29 Young children and pregnant women with PIDD have safely received subcutaneous infusions of immunoglobulin.30,31 And while little data exists on the use of subcutaneous immunoglobulin therapy in patients with significant thrombocytopenia, anticoagulant use or bleeding disorders, there is a report of the safe use of subcutaneous therapy in a child with CVID and von Willebrand disease.32

Comparative costs of immunoglobulin therapy

Positive_regulation (exists) of Gene_expression (therapy) of immunoglobulin associated with coagulation disorder, thrombocytopenia and disease
3) Confidence 0.35 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2817783 Disease Relevance 0.74 Pain Relevance 0
The studies do agree that inhaled 23-PPV is less effective than injected but in our series we did not see the increase in serum immunoglobulin levels in response to inhaled vaccine seen in some subjects (4/10 in healthy subjects, 7/10 in COPD patients) previous studies.
Positive_regulation (increase) of Gene_expression (levels) of immunoglobulin associated with pulmonary disease
4) Confidence 0.12 Published 2008 Journal Vaccine Section Body Doc Link PMC2612086 Disease Relevance 0.10 Pain Relevance 0
Intravenous immunoglobulin
Positive_regulation (Intravenous) of Gene_expression (Intravenous) of immunoglobulin
5) Confidence 0.03 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2211463 Disease Relevance 1.41 Pain Relevance 0.07
Passive transfer of immunoglobulin fractions that have been immunoabsorbed with pemphigus antigen do not cause blister formation (Amagai et al 1994).
Positive_regulation (transfer) of Gene_expression (transfer) of immunoglobulin associated with blister and bullous skin disease
6) Confidence 0.01 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936286 Disease Relevance 1.30 Pain Relevance 0
TRAF6 was also identified as a T cell-intrinsic negative regulator in mice with T cell-specific TRAF6 deletion, in which signs of hyperactive humoral immunity, including increased serum levels of immunoglobulin and DNA autoantibodies [37-39], were observed with similar clinical features of RA.
Positive_regulation (increased) of Gene_expression (levels) of immunoglobulin in T cell associated with rheumatoid arthritis
7) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.39 Pain Relevance 0.17
Smaller concentrations of nonmaternal fetal cells may aid the viability of the fetus, but higher levels may trigger autoimmune disease.50 Development of autoantibodies against smooth and cardiac muscle has also been reported.5,50 These autoantibodies may cross react with the myocardium and can cause cardiomyopathy.5,25,50,62 The higher rate of PPCM in twin pregnancies and its familial predisposition also support this autoimmune theory.32 Warraich et al. found markedly increased levels of immunoglobulin (IgG and subclasses) in PPCM patients.
Positive_regulation (support) of Gene_expression (levels) of immunoglobulin in myocardium associated with autoimmune disease and coronary heart disease
8) Confidence 0.00 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628138 Disease Relevance 0.69 Pain Relevance 0
Smaller concentrations of nonmaternal fetal cells may aid the viability of the fetus, but higher levels may trigger autoimmune disease.50 Development of autoantibodies against smooth and cardiac muscle has also been reported.5,50 These autoantibodies may cross react with the myocardium and can cause cardiomyopathy.5,25,50,62 The higher rate of PPCM in twin pregnancies and its familial predisposition also support this autoimmune theory.32 Warraich et al. found markedly increased levels of immunoglobulin (IgG and subclasses) in PPCM patients.
Positive_regulation (increased) of Gene_expression (levels) of immunoglobulin in myocardium associated with autoimmune disease and coronary heart disease
9) Confidence 0.00 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628138 Disease Relevance 0.68 Pain Relevance 0
They express high levels of inhibitory immunoglobulin like transcript (ILT) receptors, particularly ILT4, and its ligand, HLA-G.
Positive_regulation (levels) of Gene_expression (express) of immunoglobulin
10) Confidence 0.00 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 0.13 Pain Relevance 0.07

General Comments

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