INT7003

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Context Info
Confidence 0.13
First Reported 1989
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.83
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRD1) cytoplasm (OPRD1) signal transducer activity (OPRD1)
Anatomy Link Frequency
brain 2
OPRD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 8 100.00 Very High Very High Very High
Opioid 8 100.00 Very High Very High Very High
antagonist 2 96.80 Very High Very High Very High
narcan 2 95.92 Very High Very High Very High
mu opioid receptor 2 95.84 Very High Very High Very High
agonist 5 88.36 High High
MU agonist 5 85.64 High High
analgesia 1 85.48 High High
tail-flick 1 78.72 Quite High
Delta opioid receptors 2 77.84 Quite High
Disease Link Frequency Relevance Heat
Shock 4 99.34 Very High Very High Very High
Stress 3 98.74 Very High Very High Very High
Urological Neuroanatomy 1 97.52 Very High Very High Very High
Neuroblastoma 2 75.00 Quite High
Bordatella Infection 1 63.44 Quite High
Decompression Sickness 1 31.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, antagonist-induced increases in adenylate cyclase activity were observed only after chronic PLO17 administration.2+ Finally, chronic pretreatment of cells with PLO17 (10 microM) resulted in a significant decrease in mu opioid, but not delta opioid receptor, binding, whereas treatment with DPDPE (0.3 microM) resulted in a significant decrease in delta opioid, but not mu opioid receptor binding.
Negative_regulation (decrease) of delta opioid receptor Binding (binding) of associated with antagonist, mu opioid receptor, opioid receptor and opioid
1) Confidence 0.13 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8035314 Disease Relevance 0.14 Pain Relevance 0.93
Treatment with MTSEA significantly inhibited [3H]diprenorphine binding to 11 of 22 mutants of the rat mu receptor and 9 of 22 mutants of the human delta receptor and 10 of 22 mutants of the human kappa receptor.
Negative_regulation (inhibited) of delta receptor Binding (binding) of
2) Confidence 0.03 Published 2001 Journal Biochemistry Section Abstract Doc Link 11434771 Disease Relevance 0 Pain Relevance 0.29
Moreover, the presumptive mild stress of handling in the foot shock control group was sufficient to decrease mu or delta receptor binding in seven out of 17 brain regions investigated (including the frontal cortex and olfactory tubercle where both mu and delta binding were increased) when compared to unhandled deprivation control animals.
Negative_regulation (decrease) of delta receptor Binding (binding) of in brain associated with stress, shock and urological neuroanatomy
3) Confidence 0.01 Published 1992 Journal Neuroscience Section Abstract Doc Link 1336824 Disease Relevance 0.69 Pain Relevance 0.49
In particular, gradual augmentation of the positive charge from 1+ to 3+ in a series of dermorphin-(1-4) tetrapeptide analogues produced an enhancement of mu-receptor affinity and a progressive decrease in delta-receptor affinity, resulting in increasingly higher mu-receptor selectivity.
Negative_regulation (decrease) of delta-receptor Binding (affinity) of
4) Confidence 0.00 Published 1989 Journal J. Med. Chem. Section Abstract Doc Link 2537427 Disease Relevance 0 Pain Relevance 0.18

General Comments

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