INT70031

Context Info Confidence 0.05 First Reported 1997 Last Reported 1997 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 1.42 Pain Relevance 1.21

extracellular region (IL1B, PRF1) endosome (PRF1) aging (IL1B) cell-cell signaling (IL1B) cytosol (IL1B) extracellular space (IL1B)

IL1B (Homo sapiens) PRF1 (Homo sapiens)

Pain Link Frequency Relevance Heat Neuritis 11 98.68 Sciatic nerve 2 96.20 cytokine 6 92.36 Peripheral nervous system 4 75.00

Disease Link Frequency Relevance Heat Disease 2 100.00 Experimental Autoimmune Neuritis 11 98.68 Necrosis 1 71.88 Cancer 1 71.52 Syndrome 3 64.40 Immunization 1 59.52 Autoimmune Disease 1 55.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The data argue for a major proinflammatory role for IL-1 beta, IL-6, TNF-alpha, TNF-beta, and IL-12 and a disease downregulating function for both cytolysin and IL-10 at the target site in EAN.

IL-1 beta Regulation (role) of Negative_regulation (downregulating) of cytolysin associated with disease and neuritis

1) Confidence 0.05 Published 1997 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 9191887 Disease Relevance 1.42 Pain Relevance 1.21

General Comments

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