INT70037

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Context Info
Confidence 0.09
First Reported 1997
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.11
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (TNF, IL10) extracellular space (TNF, IL10) extracellular region (TNF, IL10)
extracellular matrix organization (TNF) cell-cell signaling (IL10) response to stress (IL10)
TNF (Homo sapiens)
IL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuritis 11 99.08 Very High Very High Very High
Sciatic nerve 2 96.20 Very High Very High Very High
cytokine 10 92.36 High High
Inflammatory mediators 3 88.96 High High
Peripheral nervous system 4 75.00 Quite High
Inflammation 5 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Versed 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 4 100.00 Very High Very High Very High
Experimental Autoimmune Neuritis 11 99.08 Very High Very High Very High
INFLAMMATION 9 88.96 High High
Nicotine Addiction 66 86.16 High High
Pulmonary Disease 40 77.80 Quite High
Necrosis 2 71.88 Quite High
Cancer 2 71.52 Quite High
Syndrome 3 64.40 Quite High
Immunization 1 59.52 Quite High
Autoimmune Disease 1 55.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data argue for a major proinflammatory role for IL-1 beta, IL-6, TNF-alpha, TNF-beta, and IL-12 and a disease downregulating function for both cytolysin and IL-10 at the target site in EAN.
TNF-alpha Regulation (role) of IL-10 associated with disease and neuritis
1) Confidence 0.09 Published 1997 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 9191887 Disease Relevance 1.42 Pain Relevance 1.21
In addition, differential regulation of TLR2 by IL-1, IL-10 and GM-CSF (upregulation) and IFN-gamma, TNF-?
TNF Regulation (regulation) of IL-10
2) Confidence 0.03 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 0.69 Pain Relevance 0.04

General Comments

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