INT70043

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Context Info
Confidence 0.18
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 3.59
Pain Relevance 2.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6, IL10) extracellular region (IL6, IL10) aging (IL6)
intracellular (IL10) cell-cell signaling (IL10) response to stress (IL10)
Anatomy Link Frequency
plasma 1
IL6 (Homo sapiens)
IL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 67 100.00 Very High Very High Very High
Inflammation 38 100.00 Very High Very High Very High
Inflammatory response 14 99.72 Very High Very High Very High
Neuritis 11 99.08 Very High Very High Very High
Sciatic nerve 2 96.20 Very High Very High Very High
Peripheral nervous system 4 75.00 Quite High
chemokine 10 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 51 100.00 Very High Very High Very High
Disease 20 100.00 Very High Very High Very High
Necrosis 5 99.20 Very High Very High Very High
Experimental Autoimmune Neuritis 11 99.08 Very High Very High Very High
Cancer 4 98.84 Very High Very High Very High
Diabetes Mellitus 14 91.36 High High
Influenza Virus Infection 15 88.28 High High
Critical Illness 41 82.32 Quite High
Infection 14 69.64 Quite High
Syndrome 3 64.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
and IL-6, with no effect on the anti-inflammatory cytokine IL-10.
IL-6 Neg (no) Regulation (effect) of IL-10 associated with inflammation and cytokine
1) Confidence 0.18 Published 2005 Journal Crit Care Section Abstract Doc Link PMC1414017 Disease Relevance 1.06 Pain Relevance 0.45
IL6 is known to be responsible for regulating plasma levels of IL1RA and IL10 [16].
IL6 Regulation (responsible) of IL10 in plasma
2) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 1.11 Pain Relevance 0.35
The data argue for a major proinflammatory role for IL-1 beta, IL-6, TNF-alpha, TNF-beta, and IL-12 and a disease downregulating function for both cytolysin and IL-10 at the target site in EAN.
IL-6 Regulation (role) of IL-10 associated with disease and neuritis
3) Confidence 0.05 Published 1997 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 9191887 Disease Relevance 1.42 Pain Relevance 1.21

General Comments

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