INT70048

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Context Info
Confidence 0.55
First Reported 1997
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 90
Total Number 92
Disease Relevance 71.34
Pain Relevance 25.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL10) extracellular region (IL10) intracellular (IL10)
cell-cell signaling (IL10) response to stress (IL10)
Anatomy Link Frequency
T cells 20
macrophages 10
plasma 7
blood 6
naive T cells 4
IL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 2420 100.00 Very High Very High Very High
Inflammation 2004 100.00 Very High Very High Very High
Inflammatory mediators 78 100.00 Very High Very High Very High
rheumatoid arthritis 240 99.84 Very High Very High Very High
antidepressant 16 99.78 Very High Very High Very High
Inflammatory response 214 99.60 Very High Very High Very High
spastic colon 90 99.54 Very High Very High Very High
Chronic pancreatitis 22 99.48 Very High Very High Very High
Neuritis 13 99.30 Very High Very High Very High
chemokine 368 99.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2285 100.00 Very High Very High Very High
Metabolic Syndrome 19 99.88 Very High Very High Very High
Immune Reconstitution Inflammatory Syndrome 284 99.84 Very High Very High Very High
Rheumatoid Arthritis 242 99.84 Very High Very High Very High
Inflammatory Breast Neoplasms 134 99.84 Very High Very High Very High
Hepatocellular Cancer 88 99.84 Very High Very High Very High
Targeted Disruption 143 99.82 Very High Very High Very High
Sepsis 119 99.72 Very High Very High Very High
Cancer 509 99.68 Very High Very High Very High
Graft Vs Host Disease 39 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, exposure to a lower concentration (1 microM) of the antidepressants tended to increase T-cell-derived IL-10 production, with significant effects elicited by the noradrenaline reuptake inhibitors reboxetine and desipramine.
Positive_regulation (increase) of Gene_expression (production) of IL-10 in T-cell associated with desipramine, antidepressant and noradrenaline
1) Confidence 0.55 Published 2006 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 16388933 Disease Relevance 0.18 Pain Relevance 1.00
Plasma concentrations of epinephrine, norepinephrine, cortisol, IL-6 and IL-10 as well as monocyte surface expression of HLA-DR and their ex vivo capacity to release TNF-alpha after LPS stimulation were measured perioperatively.
Positive_regulation (measured) of Gene_expression (expression) of IL-10 in Plasma
2) Confidence 0.47 Published 2003 Journal Cytokine Section Abstract Doc Link 14609565 Disease Relevance 0.36 Pain Relevance 0.52
The observed benefit was derived from interactions between the injected MSCs and lung macrophages leading to increased IL-10 production via a prostaglandin E2-dependent mechanism.
Positive_regulation (leading) of Gene_expression (production) of IL-10 in macrophages
3) Confidence 0.44 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2956462 Disease Relevance 0.53 Pain Relevance 0.08
By contrast, mice with transgenic T cells overexpressing IL-10 are protected from atherosclerosis, [39] and in several experimental models, transfer of Tregs will also inhibit atherosclerosis [40].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of IL-10 in T cells associated with targeted disruption and atherosclerosis
4) Confidence 0.44 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868866 Disease Relevance 1.91 Pain Relevance 0.20
Endomorphins 1 and 2 inhibited lipopolysaccharide (LPS)-stimulated IL-10 and IL-12 production in THP-1 differentiated to macrophage-like cells by phorbol 12-myristate 13-acetate (PMA).
Spec (like) Positive_regulation (stimulated) of Gene_expression (production) of IL-10 in THP-1
5) Confidence 0.43 Published 2002 Journal Scand. J. Immunol. Section Abstract Doc Link 12193227 Disease Relevance 0 Pain Relevance 0.14
During the last months of pregnancy Treg lymphocytes level is elevated leading to overexpression of IL-4 and IL-10.
Positive_regulation (overexpression) of Gene_expression (overexpression) of IL-10 in lymphocytes
6) Confidence 0.40 Published 2008 Journal Presse Med Section Abstract Doc Link 18819772 Disease Relevance 0.72 Pain Relevance 0.31
activity may be related to the simultaneous presence of elevated levels of IL-10 and TGF-?
Positive_regulation (elevated) of Gene_expression (levels) of IL-10
7) Confidence 0.37 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2910702 Disease Relevance 0.73 Pain Relevance 0.20
Increased expression of IL-10, both at protein and mRNA level, has been detected in OA human cartilage [10], but its role in OA pathogenesis need to be further investigated.
Positive_regulation (Increased) of Gene_expression (expression) of IL-10 in cartilage associated with osteoarthritis
8) Confidence 0.35 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2268688 Disease Relevance 0.54 Pain Relevance 0.32
The nociceptive status of CP patients correlated with pancreatic PACAP levels and with IL-10 bias of PACAP-exposed CP PBMC.
Positive_regulation (pancreatic) of Gene_expression (levels) of IL-10 in PBMC associated with nociception and chronic pancreatitis
9) Confidence 0.35 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17962362 Disease Relevance 0.95 Pain Relevance 1.00
For example, we have demonstrated previously that in-hospital resuscitation with HSD enhances spontaneous and LPS-stimulated IL-10 expression in blood monocytes of shock patients [14], which corresponds with increased production by tissue macrophages in rodent models of shock/resuscitation [92-94].
Positive_regulation (enhances) of Gene_expression (expression) of IL-10 in macrophages associated with shock
10) Confidence 0.35 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 0.87 Pain Relevance 0.07
Conversely, synthesis of the anti-inflammatory cytokine IL-10 only increased significantly at very high concentrations of supplemented PRL.
Positive_regulation (increased) of Gene_expression (synthesis) of IL-10 associated with inflammation and cytokine
11) Confidence 0.35 Published 2004 Journal Eur. Cytokine Netw. Section Abstract Doc Link 15319167 Disease Relevance 0.51 Pain Relevance 0.26
This observation correlates with the elevated levels of TLR3, 4, and 7, Th2 cytokines (IL6 and IL10) at protein level and IL4, IL5, IL6, IL10 at gene level.
Positive_regulation (elevated) of Gene_expression (levels) of IL10 associated with cytokine
12) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 1.13 Pain Relevance 0.19
Comparison of lung cytokines and chemokines at protein and gene levels showed comparable elevated levels of IL12B, CXCL8, IL1B, CCL3, IL1A and IL6 while IL17, TNF and IL10 were elevated only at the gene level.
Positive_regulation (elevated) of Gene_expression (levels) of IL10 in lung associated with chemokine and cytokine
13) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 0.56 Pain Relevance 0.14
This observation correlates with the elevated levels of TLR3, 4, and 7, Th2 cytokines (IL6 and IL10) at protein level and IL4, IL5, IL6, IL10 at gene level.
Positive_regulation (elevated) of Gene_expression (levels) of IL10 associated with cytokine
14) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 1.15 Pain Relevance 0.19
The disease severity correlated with increased plasma levels of IL1RA, IL2, IL6, CCL3, CCL4 and IL10.
Positive_regulation (increased) of Gene_expression (levels) of IL10 in plasma associated with disease
15) Confidence 0.34 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2948498 Disease Relevance 0.59 Pain Relevance 0.07
Comparison of lung cytokines and chemokines at protein and gene levels showed comparable elevated levels of IL12B, CXCL8, IL1B, CCL3, IL1A and IL6 while IL17, TNF and IL10 were elevated only at the gene level.
Positive_regulation (elevated) of Gene_expression (levels) of IL10 in lung associated with chemokine and cytokine
16) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 0.56 Pain Relevance 0.14
Patients with hyperglycemia on admission to the ICU had increased levels of IL-6 and IL-10, although after multivariate analysis only IL-6 was associated with hyperglycemia [22].
Positive_regulation (increased) of Gene_expression (levels) of IL-10 associated with hyperglycemia
17) Confidence 0.34 Published 2005 Journal Crit Care Section Body Doc Link PMC1414017 Disease Relevance 1.30 Pain Relevance 0.34
patients presented significantly higher levels than high IL-10/low TNF?
Positive_regulation (levels) of Gene_expression (presented) of IL-10
18) Confidence 0.31 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526590 Disease Relevance 0.39 Pain Relevance 0.12
The observed benefit was derived from interactions between the injected MSCs and lung macrophages leading to increased IL-10 production via a prostaglandin E2-dependent mechanism.
Positive_regulation (increased) of Gene_expression (production) of IL-10 in macrophages
19) Confidence 0.30 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2956462 Disease Relevance 0.52 Pain Relevance 0.08
It has been observed recently that whereas women with uncomplicated obesity have increased serum levels of IL-10, those with the metabolic syndrome do not [36].
Positive_regulation (increased) of Gene_expression (levels) of IL-10 associated with metabolic syndrome
20) Confidence 0.29 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868866 Disease Relevance 1.81 Pain Relevance 0.29

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