INT70049

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Context Info
Confidence 0.32
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.66
Pain Relevance 3.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (LTA) extracellular space (LTA) extracellular region (LTA)
cell-cell signaling (LTA)
Anatomy Link Frequency
sciatic nerve 2
muscles 2
T-cell 2
LTA (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuritis 22 99.48 Very High Very High Very High
Sciatic nerve 4 99.24 Very High Very High Very High
cytokine 41 99.16 Very High Very High Very High
Pain 1 98.60 Very High Very High Very High
rheumatoid arthritis 24 98.24 Very High Very High Very High
Peripheral nervous system 8 91.96 High High
Inflammatory response 3 79.52 Quite High
Inflammation 71 74.16 Quite High
antagonist 15 57.04 Quite High
depression 3 50.00 Quite Low
Disease Link Frequency Relevance Heat
Cancer 8 100.00 Very High Very High Very High
Necrosis 5 100.00 Very High Very High Very High
Experimental Autoimmune Neuritis 22 99.48 Very High Very High Very High
Pain 1 98.60 Very High Very High Very High
Rheumatoid Arthritis 24 98.24 Very High Very High Very High
Pruritus 2 98.24 Very High Very High Very High
Disease 32 96.44 Very High Very High Very High
Syndrome 14 96.20 Very High Very High Very High
Wheal 3 92.64 High High
Immunization 2 91.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is evidence of enhanced LT production in the pathogenesis of AD.
Positive_regulation (enhanced) of Gene_expression (production) of LT
1) Confidence 0.32 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945673 Disease Relevance 1.21 Pain Relevance 0.20
, LT production was increased in the n-3 LCPUFA-supplemented group compared with placebo at 6 months.
Positive_regulation (increased) of Gene_expression (production) of LT
2) Confidence 0.27 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483446 Disease Relevance 0.11 Pain Relevance 0.11
It remains to be established why low-dose n-3 LCPUFA supplementation promotes production of LT but not the other T-cell cytokines, IFN?
Positive_regulation (promotes) of Gene_expression (production) of LT in T-cell associated with cytokine
3) Confidence 0.27 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483446 Disease Relevance 0.22 Pain Relevance 0.19
Nevertheless, such increases in LT production can be protective against tissue damage in RA.
Positive_regulation (increases) of Gene_expression (production) of LT associated with rheumatoid arthritis
4) Confidence 0.24 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483446 Disease Relevance 0.29 Pain Relevance 0.23
Masseter (LMM, 17.05; RMM, 16.30), and the anterior temporalis muscles (LTA, 17.81; RTA, 17.69) were activated during swallowing, but had a lower SEMG value than the submental group.
Positive_regulation (activated) of Gene_expression (value) of LTA in muscles
5) Confidence 0.24 Published 2008 Journal BMC Oral Health Section Body Doc Link PMC2294114 Disease Relevance 0 Pain Relevance 0
To study the potential role of cytokines in EAN, we used in situ hybridization to detect mRNA expression of interleukin 1 beta (IL-1 beta), IL-6, IL-10, IL-12, tumor necrosis factor-alpha (TNF-alpha), TNF-beta, and cytolysin in sciatic nerve sections over the course of EAN.
Positive_regulation (detect) of Gene_expression (expression) of TNF-beta in sciatic nerve associated with necrosis, cancer, sciatic nerve, neuritis and cytokine
6) Confidence 0.06 Published 1997 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 9191887 Disease Relevance 1.44 Pain Relevance 1.22
TNF-alpha, TNF-beta, and IL-12 mRNA expression was maximally upmodulated on Day 14 p.i., i.e., at height of clinical EAN, favoring a role for these cytokines in disease development.
Positive_regulation (upmodulated) of Gene_expression (expression) of TNF-beta associated with disease, neuritis and cytokine
7) Confidence 0.06 Published 1997 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 9191887 Disease Relevance 1.39 Pain Relevance 1.30

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