INT70051

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Context Info
Confidence 0.25
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.61
Pain Relevance 3.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL12A) extracellular region (IL12A) cytoplasm (IL12A)
Anatomy Link Frequency
B cells 1
NK cell 1
peripheral nervous system 1
IL12A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 128 100.00 Very High Very High Very High
Neuritis 11 99.62 Very High Very High Very High
cytokine 102 99.58 Very High Very High Very High
Enkephalin 4 99.40 Very High Very High Very High
antagonist 8 99.28 Very High Very High Very High
corticosteroid 13 98.88 Very High Very High Very High
Peripheral nervous system 4 98.48 Very High Very High Very High
Neuropeptide 2 96.72 Very High Very High Very High
cINOD 3 96.56 Very High Very High Very High
Osteoarthritis 10 91.92 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 149 100.00 Very High Very High Very High
Experimental Autoimmune Neuritis 11 99.62 Very High Very High Very High
Cancer 67 99.32 Very High Very High Very High
Lymphoproliferative Disease 1 96.68 Very High Very High Very High
Autoimmune Disease 5 96.08 Very High Very High Very High
Leukemia 3 95.32 Very High Very High Very High
Body Weight 3 95.20 Very High Very High Very High
Adhesions 11 93.68 High High
Osteoarthritis 10 91.92 High High
Immunization 1 91.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULT: Met-enk promoted NK activity at 1 x 10(-8) - 1 x 10(-5) mol.L-1, increased TNF-alpha production both in vitro and in vivo, and enhanced IL-12 p35 gene transcription after ip 0.1 mg.kg-1 for 6 d.
Transcription (transcription) of IL-12
1) Confidence 0.25 Published 1996 Journal Zhongguo Yao Li Xue Bao Section Body Doc Link 9772675 Disease Relevance 0 Pain Relevance 0
Cytokine dichotomy in peripheral nervous system influences the outcome of experimental allergic neuritis: dynamics of mRNA expression for IL-1 beta, IL-6, IL-10, IL-12, TNF-alpha, TNF-beta, and cytolysin.
Transcription (expression) of IL-12 in peripheral nervous system associated with peripheral nervous system, experimental autoimmune neuritis, neuritis and cytokine
2) Confidence 0.23 Published 1997 Journal Clin. Immunol. Immunopathol. Section Title Doc Link 9191887 Disease Relevance 1.37 Pain Relevance 1.30
We [1], [9] have previously shown that the IL-12RB2 gene, encoding the IL-12R chain essential for IL-12 signal transduction, functions as a tumor suppressor in human neoplastic B cells from various chronic lymphoproliferative disorders and acute lymphoblastic leukemia.
Transcription (transduction) of IL-12 in B cells associated with leukemia, cancer and lymphoproliferative disease
3) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702099 Disease Relevance 0.64 Pain Relevance 0.12
Augmentation of TNF-alpha production, NK cell activity and IL-12 p35 mRNA expression by methionine enkephalin.
Transcription (expression) of IL-12 in NK cell associated with enkephalin
4) Confidence 0.19 Published 1996 Journal Zhongguo Yao Li Xue Bao Section Title Doc Link 9772675 Disease Relevance 0 Pain Relevance 0.24
We have also studied cytokines associated with the function of Th2 (IL-4 and IL-10) and Th1 (IL-2, IL-12 (p70), and INF?)
Transcription (function) of IL-12 associated with cytokine
5) Confidence 0.14 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991033 Disease Relevance 1.19 Pain Relevance 0.76
and IL-12 p35 transcription.
Transcription (transcription) of IL-12 p35
6) Confidence 0.07 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621411 Disease Relevance 1.08 Pain Relevance 0.09
Corticosteroids may also control airway inflammation by increasing the transcription of anti-inflammatory genes like IL-10, IL-12 or IL-1 receptor antagonist, the gene products of which appear to be the most potent anti-inflammatory drugs for use in the treatment of airway inflammation [63].
Transcription (transcription) of IL-12 associated with corticosteroid, inflammation, antagonist and cinod
7) Confidence 0.05 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 1.32 Pain Relevance 0.89

General Comments

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