INT70052

Context Info Confidence 0.41 First Reported 1997 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 3.10 Pain Relevance 2.58

endosome (PRF1) extracellular region (PRF1) cytoplasmic membrane-bounded vesicle (PRF1) plasma membrane (PRF1)

Anatomy Link Frequency sciatic nerves 1 peripheral nervous system 1 PRF1 (Homo sapiens)

Pain Link Frequency Relevance Heat Neuritis 22 99.62 Sciatic nerve 4 99.44 Peripheral nervous system 8 98.48 cytokine 12 98.28 Inflammation 3 10.00 Inflammatory response 2 5.00 Paracetamol 1 5.00 tolerance 1 5.00 Angina 1 5.00

Disease Link Frequency Relevance Heat Experimental Autoimmune Neuritis 22 99.92 Disease 8 98.72 Autoimmune Disease 2 97.52 Immunization 2 93.36 Syndrome 6 88.52 Apoptosis 7 85.52 Cancer 11 81.08 Necrosis 2 80.84 Cardiovascular Disease 3 77.76 Cv General 3 Under Development 1 77.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Despite substantial variability, there was a trend toward increased transcript abundance for PRF1, IL2RB, and KIR3DL1 with increasing urinary arsenic concentration.

Transcription (abundance) of PRF1

1) Confidence 0.41 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2290973 Disease Relevance 0.32 Pain Relevance 0

Cytokine dichotomy in peripheral nervous system influences the outcome of experimental allergic neuritis: dynamics of mRNA expression for IL-1 beta, IL-6, IL-10, IL-12, TNF-alpha, TNF-beta, and cytolysin.

Transcription (expression) of cytolysin in peripheral nervous system associated with peripheral nervous system, experimental autoimmune neuritis, neuritis and cytokine

2) Confidence 0.19 Published 1997 Journal Clin. Immunol. Immunopathol. Section Title Doc Link 9191887 Disease Relevance 1.39 Pain Relevance 1.32

On the contrary, transcription of cytolysin and IL-10 in sciatic nerves reached maxima during clinical improvement of EAN.

Transcription (ranscription ) of cytolysin in sciatic nerves associated with sciatic nerve and neuritis

3) Confidence 0.19 Published 1997 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 9191887 Disease Relevance 1.31 Pain Relevance 1.26

CD4+CD28null cells were separated by flow cytometry and assessed for antigen recognition using upregulation of interferon-gamma and perforin mRNA transcription as criteria for activation.

Transcription (transcription) of perforin mRNA

4) Confidence 0.01 Published 2004 Journal Circulation Section Body Doc Link 14993140 Disease Relevance 0.08 Pain Relevance 0

General Comments

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