INT70053

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Context Info
Confidence 0.12
First Reported 1997
Last Reported 2005
Negated 2
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 3.41
Pain Relevance 2.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (PRF1) extracellular region (PRF1) cytoplasmic membrane-bounded vesicle (PRF1)
plasma membrane (PRF1)
Anatomy Link Frequency
T cells 10
sciatic nerve 2
PRF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 155 99.84 Very High Very High Very High
Sciatic nerve 2 99.84 Very High Very High Very High
Neuritis 11 99.30 Very High Very High Very High
cytokine 31 99.16 Very High Very High Very High
Arthritis 80 92.96 High High
rheumatoid arthritis 100 92.04 High High
Peripheral nervous system 4 91.96 High High
Inflammation 10 91.80 High High
tolerance 5 5.00 Very Low Very Low Very Low
Infliximab 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 21 100.00 Very High Very High Very High
Cancer 21 100.00 Very High Very High Very High
Low Back Pain 155 99.84 Very High Very High Very High
Experimental Autoimmune Neuritis 11 99.30 Very High Very High Very High
Syndrome 8 96.20 Very High Very High Very High
Seronegative Spondarthritis 80 92.96 High High
Rheumatoid Arthritis 100 92.04 High High
INFLAMMATION 10 91.80 High High
Immunization 1 91.32 High High
Autoimmune Disease 1 87.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To study the potential role of cytokines in EAN, we used in situ hybridization to detect mRNA expression of interleukin 1 beta (IL-1 beta), IL-6, IL-10, IL-12, tumor necrosis factor-alpha (TNF-alpha), TNF-beta, and cytolysin in sciatic nerve sections over the course of EAN.
Positive_regulation (detect) of Gene_expression (expression) of cytolysin in sciatic nerve associated with necrosis, cancer, sciatic nerve, neuritis and cytokine
1) Confidence 0.12 Published 1997 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 9191887 Disease Relevance 1.45 Pain Relevance 1.23
As expected, LPS-induced perforin production of CD4+CD28null T cells was reversed by blocking sCD14 and mCD14 (24.0 ± 16.3% versus 3.1 ± 2.5% perforin+ cells, P = 0.006) but not by isotype control antibody (Figure 5b).
Positive_regulation (-) of Gene_expression (production) of perforin in T cells
2) Confidence 0.06 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.24 Pain Relevance 0.24
Blocking assays with antibodies directed against TLR4 were then performed to specifically address the role of TLR4 in LPS-mediated perforin production of CD4+CD28null T cells.
Positive_regulation (mediated) of Gene_expression (production) of perforin in T cells
3) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.20 Pain Relevance 0.20
LPS-mediated perforin production of CD4+CD28null T cells depends on CD14 and TLR4
Positive_regulation (mediated) of Gene_expression (production) of perforin in T cells
4) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.69 Pain Relevance 0.42
In our experiments both the addition of recombinant sCD14 and autologous serum had a comparable additional effect on LPS-induced perforin production of CD4+CD28null T cells, which indicates serum LPS binding protein not to be indispensable in AS.
Positive_regulation (indispensable) of Neg (not) Gene_expression (production) of perforin in T cells associated with spinal inflammation
5) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.59 Pain Relevance 0.40
CD4+CD28+ T cells did not produce perforin after co-incubation with LPS, even after addition of sCD14 or autologous serum (Figure 4a and data not shown).
Neg (not) Positive_regulation (after) of Neg (not) Gene_expression (produce) of perforin in T cells
6) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.24 Pain Relevance 0.24

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