INT70056

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Context Info
Confidence 0.32
First Reported 1997
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.47
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chn1) intracellular (Chn1)
Anatomy Link Frequency
neuron 1
vas deferens 1
Chn1 (Mus musculus)
Pain Link Frequency Relevance Heat
orphanin 17 100.00 Very High Very High Very High
opioid receptor 3 75.12 Quite High
narcan 1 73.28 Quite High
antagonist 4 68.56 Quite High
cerebral cortex 1 56.00 Quite High
cytokine 26 25.48 Quite Low
agonist 1 25.00 Low Low
Opioid 1 25.00 Low Low
nociceptor 1 25.00 Low Low
Inflammation 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Motor Neuron Diseases 107 97.52 Very High Very High Very High
Tics 1 71.92 Quite High
Neurodegenerative Disease 9 48.48 Quite Low
Targeted Disruption 8 44.24 Quite Low
Death 19 31.12 Quite Low
Ataxia 1 12.16 Low Low
Mouth Disease 1 10.48 Low Low
Charcot Marie Tooth Disease 2 9.92 Low Low
Disease 33 5.00 Very Low Very Low Very Low
Stress 23 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nociceptin (NC) and some of its fragments as well as nociceptin-(1-13)-peptide amide [NC- (1-13)-NH2] and a series of its analogues were prepared and tested in the mouse vas deferens in an attempt to identify the sequences involved in the activation (message) and in the binding (address) of nociceptin to its receptor.
Gene_expression (prepared) of NC in vas deferens associated with orphanin
1) Confidence 0.32 Published 1997 Journal J. Med. Chem. Section Abstract Doc Link 9191955 Disease Relevance 0.07 Pain Relevance 0.60
While most of the above genes are known to be expressed in multiple cell types, some of them (CHN1, NPTN, SNAP25, OLFM1, VSNL1) are neuron-specific.
Gene_expression (expressed) of CHN1 in neuron
2) Confidence 0.18 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 0.40 Pain Relevance 0.03
Similar data was seen using IL-13 injections (Figure 2, PC and NC1, NC2).
Gene_expression (injections) of NC1
3) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645503 Disease Relevance 0 Pain Relevance 0

General Comments

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