INT70086

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Context Info
Confidence 0.50
First Reported 1997
Last Reported 1997
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 1.58
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (TGM1) transferase activity, transferring acyl groups (TGM1)
Anatomy Link Frequency
bands 2
TGM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 3 97.76 Very High Very High Very High
monoamine 3 94.28 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 3 97.56 Very High Very High Very High
Disease 12 97.52 Very High Very High Very High
Alzheimer's Dementia 6 83.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that inhibition of TGase-induced cross-linking of A beta is a potential pharmacologic target for the treatment of AD.
Negative_regulation (inhibition) of TGase-induced Binding (cross-linking) of associated with disease
1) Confidence 0.50 Published 1997 Journal Life Sci. Section Abstract Doc Link 9194688 Disease Relevance 0.52 Pain Relevance 0.13
A method is also presented for the determination of percent inhibition of TGase-induced A beta cross-linking based on the separated monomer, dimer and polymer bands on SDS-PAGE gels.
Negative_regulation (inhibition) of TGase-induced Binding (cross-linking) of in bands
2) Confidence 0.37 Published 1997 Journal Life Sci. Section Abstract Doc Link 9194688 Disease Relevance 0.49 Pain Relevance 0.12
This report evaluated the potential of a total of ten different pharmacological agents to inhibit TGase-induced cross-linking of A beta, including known TGase inhibitors (dansylcadaverine, spermine), non-steroidal anti-inflammatory drugs (indomethacin, meclofenamic acid, diflunisal, salicylic acid), monoamine oxidase inhibitors (tranylcypromine, phenelzine), an acetylcholinesterase inhibitor (tacrine), and an iron chelating agent (deferoxamine).
Negative_regulation (inhibit) of TGase Neg (inhibit) Binding (cross-linking) of associated with inflammation, cinod and monoamine
3) Confidence 0.36 Published 1997 Journal Life Sci. Section Abstract Doc Link 9194688 Disease Relevance 0.57 Pain Relevance 0.14

General Comments

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