INT70088

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Context Info
Confidence 0.41
First Reported 1997
Last Reported 2008
Negated 1
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 5.30
Pain Relevance 1.22

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protein modification process (TGM1) transferase activity, transferring acyl groups (TGM1)
Anatomy Link Frequency
neuronal 2
bands 1
TGM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 5 97.76 Very High Very High Very High
Inflammatory response 2 95.36 Very High Very High Very High
monoamine 5 94.28 High High
anesthesia 4 91.80 High High
cytokine 2 89.80 High High
Inflammation 2 89.40 High High
palliative 1 69.88 Quite High
Pain 4 55.88 Quite High
ischemia 1 48.84 Quite Low
Disease Link Frequency Relevance Heat
Ataxia 2 99.98 Very High Very High Very High
Apoptosis 7 98.84 Very High Very High Very High
Celiac Disease 2 98.28 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 102 97.72 Very High Very High Very High
INFLAMMATION 9 97.56 Very High Very High Very High
Cancer 2 97.56 Very High Very High Very High
Disease 20 97.28 Very High Very High Very High
Neurological Disease 3 95.28 Very High Very High Very High
Death 2 92.68 High High
Autoimmune Disease 2 87.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that inhibition of TGase-induced cross-linking of A beta is a potential pharmacologic target for the treatment of AD.
TGase-induced Binding (cross-linking) of associated with disease
1) Confidence 0.41 Published 1997 Journal Life Sci. Section Abstract Doc Link 9194688 Disease Relevance 0.52 Pain Relevance 0.13
All but one (salicylic acid) of these ten agents had an inhibitory effect on TGase-induced A beta cross-linking.
TGase-induced Binding (cross-linking) of
2) Confidence 0.41 Published 1997 Journal Life Sci. Section Abstract Doc Link 9194688 Disease Relevance 0.53 Pain Relevance 0.13
A method is also presented for the determination of percent inhibition of TGase-induced A beta cross-linking based on the separated monomer, dimer and polymer bands on SDS-PAGE gels.
TGase-induced Binding (cross-linking) of in bands
3) Confidence 0.41 Published 1997 Journal Life Sci. Section Abstract Doc Link 9194688 Disease Relevance 0.48 Pain Relevance 0.12
This report evaluated the potential of a total of ten different pharmacological agents to inhibit TGase-induced cross-linking of A beta, including known TGase inhibitors (dansylcadaverine, spermine), non-steroidal anti-inflammatory drugs (indomethacin, meclofenamic acid, diflunisal, salicylic acid), monoamine oxidase inhibitors (tranylcypromine, phenelzine), an acetylcholinesterase inhibitor (tacrine), and an iron chelating agent (deferoxamine).
TGase Neg (inhibit) Binding (cross-linking) of associated with inflammation, cinod and monoamine
4) Confidence 0.41 Published 1997 Journal Life Sci. Section Abstract Doc Link 9194688 Disease Relevance 0.57 Pain Relevance 0.14
This report evaluated the potential of a total of ten different pharmacological agents to inhibit TGase-induced cross-linking of A beta, including known TGase inhibitors (dansylcadaverine, spermine), non-steroidal anti-inflammatory drugs (indomethacin, meclofenamic acid, diflunisal, salicylic acid), monoamine oxidase inhibitors (tranylcypromine, phenelzine), an acetylcholinesterase inhibitor (tacrine), and an iron chelating agent (deferoxamine).
TGase-induced Binding (cross-linking) of associated with inflammation, cinod and monoamine
5) Confidence 0.30 Published 1997 Journal Life Sci. Section Abstract Doc Link 9194688 Disease Relevance 0.57 Pain Relevance 0.14
Furthermore, a recent cross-sectional observational study of 374 FSW in Nigeria found a statistically significant association between use of LeJ/LiJ (n = 81) and the presence of cervicovaginal intraepithelial neoplasia (CIN) [23].
LiJ Binding (association) of associated with cancer
6) Confidence 0.19 Published 2008 Journal Retrovirology Section Body Doc Link PMC2259360 Disease Relevance 0.86 Pain Relevance 0.19
Whilst B. vaginosis appeared to show an association with LiJ/LeJ usage (55.8% in users versus 44% in non-users), this did not reach statistical significance (p = 0.06).
LiJ Spec (appeared) Binding (association) of
7) Confidence 0.17 Published 2008 Journal Retrovirology Section Body Doc Link PMC2259360 Disease Relevance 0.63 Pain Relevance 0.12
Autoantibodies in gluten ataxia recognize a novel neuronal transglutaminase.
transglutaminase Binding (recognize) of in neuronal associated with ataxia
8) Confidence 0.14 Published 2008 Journal Ann. Neurol. Section Title Doc Link 18825674 Disease Relevance 0.38 Pain Relevance 0.17
Inhibition studies showed that in those patients with ataxia and enteropathy, separate antibody populations react with the two different transglutaminase isozymes.
transglutaminase Binding (react) of
9) Confidence 0.11 Published 2008 Journal Ann. Neurol. Section Body Doc Link 18825674 Disease Relevance 0 Pain Relevance 0
Transglutaminase-catalyzed protein cross-linking in the molecular program of apoptosis and its relationship to neuronal processes.
Transglutaminase Binding (cross-linking) of in neuronal associated with apoptosis
10) Confidence 0.07 Published 1998 Journal Cell. Mol. Neurobiol. Section Title Doc Link 9876874 Disease Relevance 0.76 Pain Relevance 0.07

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