INT70089

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Context Info
Confidence 0.59
First Reported 1997
Last Reported 2010
Negated 3
Speculated 2
Reported most in Abstract
Documents 7
Total Number 9
Disease Relevance 6.45
Pain Relevance 3.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (APP) extracellular matrix organization (APP) DNA binding (APP)
cytoplasm (APP) cytosol (APP) extracellular region (APP)
Anatomy Link Frequency
macrophage 2
APP (Homo sapiens)
Pain Link Frequency Relevance Heat
Abeta 26 100.00 Very High Very High Very High
cINOD 18 99.98 Very High Very High Very High
aspirin 10 99.98 Very High Very High Very High
cOX1 2 99.00 Very High Very High Very High
COX2 2 99.00 Very High Very High Very High
Potency 1 90.64 High High
Arthritis 4 90.60 High High
imagery 1 81.48 Quite High
monoamine 1 72.00 Quite High
Inflammation 6 68.48 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 26 100.00 Very High Very High Very High
Cognitive Disorder 26 100.00 Very High Very High Very High
INFLAMMATION 16 99.86 Very High Very High Very High
Disease 200 98.92 Very High Very High Very High
Immunization 1 97.48 Very High Very High Very High
Amyloid Plaque 14 94.64 High High
Arthritis 4 90.60 High High
Increased Venous Pressure Under Development 5 75.00 Quite High
Amyloidosis 1 73.32 Quite High
Atherosclerotic Plaque 3 67.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Remarkably, the same NSAIDs reported to alter gamma-secretase activity in Alzheimer's disease also reduce macrophage activation after platelet phagocytosis and inhibit formation of Abeta-containing peptides.
Negative_regulation (inhibit) of Abeta Binding (formation) of in macrophage associated with cinod, disease and abeta
1) Confidence 0.59 Published 2006 Journal Cardiovascular & hematological disorders drug targets Section Abstract Doc Link 16724933 Disease Relevance 0.93 Pain Relevance 0.46
Aspirin prevented enhanced Abeta aggregation by aluminum, an environmental risk factor for AD.
Negative_regulation (prevented) of Abeta Binding (aggregation) of associated with aspirin, disease and abeta
2) Confidence 0.51 Published 2001 Journal Neuroreport Section Abstract Doc Link 11711868 Disease Relevance 0.86 Pain Relevance 0.70
E9 mice to a diet high in omega-3 fatty acids, however, neither improved cognition in APPswe/PS1?
Neg (neither) Negative_regulation (improved) of APP Neg (neither) Binding (cognition) of associated with cognitive disorder
3) Confidence 0.41 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2952897 Disease Relevance 0.60 Pain Relevance 0
Aspirin and non-steroidal anti-inflammatory drugs inhibit amyloid-beta aggregation.
Negative_regulation (inhibit) of amyloid-beta Neg (inhibit) Binding (aggregation) of associated with aspirin, inflammation, alzheimer's dementia and cinod
4) Confidence 0.38 Published 2001 Journal Neuroreport Section Title Doc Link 11711868 Disease Relevance 0.88 Pain Relevance 0.90
Naproxen, ibuprofen and even FDDNP significantly inhibit aggregation of the Abeta(1-40) peptide in the micromolar range.
Negative_regulation (inhibit) of Abeta Neg (inhibit) Binding (aggregation) of associated with abeta
5) Confidence 0.22 Published 2003 Journal Mol Imaging Biol Section Abstract Doc Link 14667495 Disease Relevance 0.85 Pain Relevance 0.51
At this point, inhibitors able to interact at the peripheral binding site are of particular relevance, as they might disrupt the interactions between the enzyme acetylcholinesterase and the beta-amyloid peptide.
Spec (might) Negative_regulation (disrupt) of beta-amyloid peptide Spec (might) Binding (interactions) of associated with alzheimer's dementia
6) Confidence 0.09 Published 2004 Journal Curr. Pharm. Des. Section Abstract Doc Link 15544503 Disease Relevance 0.32 Pain Relevance 0.11
Our results demonstrate that some of the known inhibitors, such as L-685,458 and III-31C as well as inhibitors IV and V, inhibit the formation of secreted Abeta(40/42) by inhibiting the formation of the intermediate Abeta(46).
Negative_regulation (inhibiting) of Abeta Binding (formation) of associated with abeta
7) Confidence 0.08 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17241131 Disease Relevance 0.15 Pain Relevance 0.61
It is also possible to inhibit the aggregation of the beta-amyloid peptide with peptide fragments or with Cu2+ and Zn2+ ion chelators.
Spec (possible) Negative_regulation (inhibit) of beta-amyloid peptide Binding (aggregation) of associated with alzheimer's dementia
8) Confidence 0.03 Published 2009 Journal Neuropsychopharmacol Hung Section Abstract Doc Link 19731816 Disease Relevance 1.25 Pain Relevance 0.03
Pharmacologic inhibition of transglutaminase-induced cross-linking of Alzheimer's amyloid beta-peptide.
Negative_regulation (inhibition) of beta-peptide Binding (cross-linking) of associated with alzheimer's dementia
9) Confidence 0.00 Published 1997 Journal Life Sci. Section Title Doc Link 9194688 Disease Relevance 0.61 Pain Relevance 0.11

General Comments

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