INT701

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.80
First Reported 1978
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 87
Total Number 87
Disease Relevance 40.50
Pain Relevance 10.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
mast cells 14
skin 10
B cells 6
leukocytes 5
basophils 4
IGHE (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 184 99.98 Very High Very High Very High
aspirin 192 99.84 Very High Very High Very High
Clonidine 8 99.80 Very High Very High Very High
Analgesic 6 99.76 Very High Very High Very High
Migraine 2 99.66 Very High Very High Very High
Codeine 3 99.64 Very High Very High Very High
dexamethasone 5 99.22 Very High Very High Very High
Antihistamine 81 98.96 Very High Very High Very High
corticosteroid 155 98.82 Very High Very High Very High
Inflammation 503 98.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urticaria 368 100.00 Very High Very High Very High
Multiple Myeloma 39 99.96 Very High Very High Very High
Myopia 1 99.90 Very High Very High Very High
Hypersensitivity 524 99.84 Very High Very High Very High
Anaphylaxis 83 99.80 Very High Very High Very High
Asthma 1072 99.72 Very High Very High Very High
Eosinophilia 77 99.70 Very High Very High Very High
Worm Infection 15 99.68 Very High Very High Very High
Headache 16 99.66 Very High Very High Very High
Anaphylactic Hypersensitivity 2 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specific IgE released from B lymphocytes circulates and binds to specific high-affinity receptors (Fc-epilson-RI) on the surface of mast cells and basophils.
Localization (released) of IgE in B lymphocytes
1) Confidence 0.80 Published 2008 Journal Core Evidence Section Body Doc Link PMC2899803 Disease Relevance 1.12 Pain Relevance 0.15
Thus, single small samples of feces can be used to measure the excretion of IgE with feces at that time.
Localization (excretion) of IgE in feces
2) Confidence 0.78 Published 1986 Journal Int. Arch. Allergy Appl. Immunol. Section Abstract Doc Link 3949413 Disease Relevance 0.35 Pain Relevance 0
The excretion of IgE with feces from healthy individuals and from others with allergy and diseases affecting the intestinal tract.
Localization (excretion) of IgE in feces associated with hypersensitivity and disease
3) Confidence 0.78 Published 1986 Journal Int. Arch. Allergy Appl. Immunol. Section Title Doc Link 3949413 Disease Relevance 0.34 Pain Relevance 0
Although functional opiate receptors may exist on mast cells and may be capable of modulating IgE-mediated histamine release, there is no evidence that these receptors account for opiate-induced histamine release.
Localization (release) of IgE in mast cells associated with opiate
4) Confidence 0.78 Published 1993 Journal Life Sci. Section Abstract Doc Link 7694026 Disease Relevance 0.33 Pain Relevance 0.91
In the present study, we have analyzed the effect of overnight culture with dexamethasone (10(-6) to 10(-7)M) on the subsequent IgE-dependent release of mediators from human mast cells derived from airway tissue, intestine, and skin.
Localization (release) of IgE in mast cells associated with dexamethasone
5) Confidence 0.78 Published 1989 Journal Am. Rev. Respir. Dis. Section Abstract Doc Link 2478059 Disease Relevance 0.16 Pain Relevance 0.20
In the group of sick children during attack (I), 20 children (80%) excreted IgE in urine, 10 children (40%) excreted eosinophils.
Localization (excreted) of IgE in eosinophils
6) Confidence 0.77 Published 1996 Journal Pediatr Pol Section Abstract Doc Link 8966062 Disease Relevance 0.58 Pain Relevance 0.09
However, the absence of an effect on IgE-secreting B cells and epsilon mRNA in nasal lavage fluid suggests that omalizumab treatment for 6 months does not significantly modulate synthesis of nasal IgE.


Localization (secreting) of IgE in B cells
7) Confidence 0.75 Published 2004 Journal Ann. Allergy Asthma Immunol. Section Body Doc Link 15478383 Disease Relevance 0 Pain Relevance 0
Only 2000 IgE molecules are needed for half maximal release of histamine from basophils (Barnes 2007; MacGlashan 1993).


Localization (release) of IgE in basophils
8) Confidence 0.75 Published 2008 Journal Core Evidence Section Body Doc Link PMC2899803 Disease Relevance 0.78 Pain Relevance 0.11
Although, there was a significant correlation between IgE levels and IFN-?
Localization (correlation) of IgE
9) Confidence 0.73 Published 2007 Journal Malar J Section Body Doc Link PMC1781948 Disease Relevance 1.04 Pain Relevance 0.15
Antigen-induced IgE-mediated release of histamine from human leukocytes, an in vitro model of allergic reactions, was blocked by imidazole and imidazole-compounds such as oxymetazoline and clonidine.
Localization (release) of IgE in leukocytes associated with hypersensitivity and clonidine
10) Confidence 0.73 Published 1978 Journal Acta Pharmacol Toxicol (Copenh) Section Abstract Doc Link 79298 Disease Relevance 0.10 Pain Relevance 0.20
Serodiagnosis has relied on an IgG and IgE ELISA using excretory-secretory antigens from adult A. caninum, but Western blot using these antigens to identify IgG4 antibodies to a protein of molecular weight 68 kDa (Ac68) promises to be more specific and sensitive.
Localization (relied) of IgE in excretory
11) Confidence 0.73 Published 1996 Journal Acta Trop. Section Abstract Doc Link 8971276 Disease Relevance 1.02 Pain Relevance 0.07
We have investigated the antianaphylactic properties of tiaramide and its metabolites in three in vitro models of anaphylaxis; namely, IgE-induced release of histamine from rat mast cells and human basophils, and IgG1-induced release of histamine from guinea pig lung slices.
Localization (release) of IgE in lung associated with anaphylaxis
12) Confidence 0.73 Published 1982 Journal Int. Arch. Allergy Appl. Immunol. Section Abstract Doc Link 6179887 Disease Relevance 0.10 Pain Relevance 0.09
Novel drugs with an increased potential in the control of MC function (e.g., anti-IgE antibodies, the intracellular protein tyrosine kinase inhibitor Syk) and mediator release (e.g., second generation antihistamines, proteinase-activated receptor antagonists) may be useful pharmacological tools for these common disorders.
Localization (release) of IgE associated with antagonist and antihistamine
13) Confidence 0.73 Published 2006 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 16371078 Disease Relevance 0.55 Pain Relevance 0.53
Lesional skin mast cells had a net histamine release of 12.3% (+/- 1.3 SEM) and 31.1% (+/- 6.0 SEM) following stimulation with the purified human anaphylotoxin C3a and mouse monoclonal antihuman IgE antibodies, respectively.
Localization (release) of IgE in mast cells
14) Confidence 0.73 Published 1987 Journal J. Invest. Dermatol. Section Abstract Doc Link 3624898 Disease Relevance 0.47 Pain Relevance 0.12
Results of direct binding and inhibition experiments and correlations with clinical findings demonstrated that the assays are relevant to the detection of succinylcholine-, decamethonium- and gallamine-reactive IgE antibodies in patients who experienced adverse reactions to these drugs.
Localization (detection) of IgE associated with adverse drug reaction
15) Confidence 0.73 Published 1985 Journal Ann Fr Anesth Reanim Section Abstract Doc Link 3159315 Disease Relevance 0.10 Pain Relevance 0.08
CLINICAL IMPLICATIONS: IgE and histamine release can be used to support the diagnosis of allergy to chlorhexidine.


Localization (release) of IgE
16) Confidence 0.72 Published 2007 Journal J. Allergy Clin. Immunol. Section Body Doc Link 17559915 Disease Relevance 0 Pain Relevance 0
None of the skin test-negative patients had specific IgE or positive histamine release to chlorhexidine.
Localization (release) of IgE in skin
17) Confidence 0.72 Published 2007 Journal J. Allergy Clin. Immunol. Section Body Doc Link 17559915 Disease Relevance 0.07 Pain Relevance 0
Sera were analyzed retrospectively for IgE and histamine release (passive sensitization) to chlorhexidine.
Localization (release) of IgE
18) Confidence 0.72 Published 2007 Journal J. Allergy Clin. Immunol. Section Body Doc Link 17559915 Disease Relevance 0.08 Pain Relevance 0
CONCLUSION: This study confirms that chlorhexidine allergy is IgE-mediated and that measurement of specific IgE and histamine release are good adjuncts to skin testing in patients with clinical history suggesting chlorhexidine allergy.
Localization (release) of IgE in skin
19) Confidence 0.72 Published 2007 Journal J. Allergy Clin. Immunol. Section Body Doc Link 17559915 Disease Relevance 0 Pain Relevance 0
IgE is formed by the B lymphocyte and after several gene rearrangement steps is secreted.
Localization (secreted) of IgE in B lymphocyte
20) Confidence 0.71 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2837605 Disease Relevance 0.35 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox