INT70104

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Context Info
Confidence 0.47
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 5.92
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CACNA1S) transmembrane transport (CACNA1S) cytoplasm (CACNA1S)
Anatomy Link Frequency
skeletal muscle 3
CACNA1S (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 27 98.12 Very High Very High Very High
Calcium channel 7 98.04 Very High Very High Very High
potassium channel 5 66.96 Quite High
headache 2 60.36 Quite High
Migraine 2 60.00 Quite High
anesthesia 2 25.76 Quite Low
Central nervous system 2 25.00 Low Low
Action potential 14 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
Mexiletine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Paralysis 63 100.00 Very High Very High Very High
Hypokalemic Periodic Paralysis 12 100.00 Very High Very High Very High
Myotonic Disorders 15 94.96 High High
Polio 4 94.44 High High
Hyperkalemic Periodic Paralysis 7 93.44 High High
Disease 26 92.32 High High
Channelopathies 12 91.36 High High
Bartter Syndrome 3 89.00 High High
Hyperkalemia 8 86.00 High High
Ataxia 2 83.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hypokalemic periodic paralysis (HypoPP) is a channel disorder caused primarily by mutations in the human skeletal muscle alpha1 subunit (CACNA1S) of the dihydropyridine-sensitive calcium channel.
Positive_regulation (caused) of HypoPP in skeletal muscle associated with hypokalemic periodic paralysis and calcium channel
1) Confidence 0.47 Published 2003 Journal Muscle Nerve Section Abstract Doc Link 12548523 Disease Relevance 0.24 Pain Relevance 0.05
We have also shown that hypokalemic periodic paralysis (hypoKPP) is caused by mutations in a gene encoding a voltage-gated calcium channel.
Positive_regulation (caused) of hypoKPP associated with hypokalemic periodic paralysis and calcium channel
2) Confidence 0.46 Published 1997 Journal Neuromuscul. Disord. Section Abstract Doc Link 9196907 Disease Relevance 1.63 Pain Relevance 0.29
Hypokalemic periodic paralysis (HypoPP) is a channel disorder caused primarily by mutations in the human skeletal muscle alpha1 subunit (CACNA1S) of the dihydropyridine-sensitive calcium channel.
Positive_regulation (caused) of paralysis in skeletal muscle associated with hypokalemic periodic paralysis and calcium channel
3) Confidence 0.41 Published 2003 Journal Muscle Nerve Section Abstract Doc Link 12548523 Disease Relevance 0.24 Pain Relevance 0.05
We have also shown that hypokalemic periodic paralysis (hypoKPP) is caused by mutations in a gene encoding a voltage-gated calcium channel.
Positive_regulation (caused) of paralysis associated with hypokalemic periodic paralysis and calcium channel
4) Confidence 0.40 Published 1997 Journal Neuromuscul. Disord. Section Abstract Doc Link 9196907 Disease Relevance 1.63 Pain Relevance 0.29
HypoPP is caused by mutations in two voltage-gated cation channels in skeletal muscle Cav1.1 (HypoPP-1) and Nav1.4 (HypoPP-2) [12, 21, 22].
Positive_regulation (caused) of HypoPP in skeletal muscle
5) Confidence 0.13 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883924 Disease Relevance 0.95 Pain Relevance 0
The results of this study indicate that characterization of NPEV isolates could provide better understanding of the epidemiology of NPEV causing paralysis.
Positive_regulation (causing) of paralysis associated with paralysis
6) Confidence 0.01 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC1804272 Disease Relevance 1.23 Pain Relevance 0

General Comments

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