INT70137

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Context Info
Confidence 0.27
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.45
Pain Relevance 4.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bdkrb2) signal transduction (Bdkrb2) plasma membrane (Bdkrb2)
signal transducer activity (Bdkrb2)
Anatomy Link Frequency
leukocyte 1
brain 1
Bdkrb2 (Mus musculus)
Pain Link Frequency Relevance Heat
Nicotine 297 100.00 Very High Very High Very High
bradykinin 167 100.00 Very High Very High Very High
b2 receptor 139 100.00 Very High Very High Very High
antagonist 47 100.00 Very High Very High Very High
B1 receptor 34 100.00 Very High Very High Very High
Pain 7 100.00 Very High Very High Very High
nociceptor 1 100.00 Very High Very High Very High
Morphine 18 98.52 Very High Very High Very High
Spinal cord 33 97.04 Very High Very High Very High
Inflammation 151 95.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 5 99.84 Very High Very High Very High
Disease 56 99.66 Very High Very High Very High
Stroke 9 99.64 Very High Very High Very High
Multiple Sclerosis 258 97.36 Very High Very High Very High
INFLAMMATION 173 95.72 Very High Very High Very High
Hyperalgesia 6 95.20 Very High Very High Very High
Targeted Disruption 14 91.32 High High
Pressure And Volume Under Development 49 90.84 High High
Cv General 4 Under Development 12 85.96 High High
Retina Disease 50 81.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
levels at day 14 (peak of disease) in both WT and B2-/- compared to control mice.
Regulation (control) of B2 associated with disease
1) Confidence 0.27 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 1.03 Pain Relevance 0.35
Thus, the present study clearly suggests an important role for B2 in mediating leukocyte adherence to vessels in brain, and extensively in spinal cord, as suggested by histology of both sites in the same animal.
Regulation (role) of B2 in brain associated with spinal cord
2) Confidence 0.27 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 0.85 Pain Relevance 0.38
On the other hand, our findings of improvement of neurological clinical score in B2-/- mice associated with impaired leukocyte recruitment parameters are in contrast to the findings of Xia et al. [41], which provide evidence for a protective role of the kinin B2 receptor against ischemic stroke.
Regulation (role) of kinin B2 receptor in leukocyte associated with stroke and b2 receptor
3) Confidence 0.18 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 1.45 Pain Relevance 0.22
The data also imply that patterns B2 and B3 appear to be regulated by steroid hormones that respond to morphine, heroin and ethanol.
Regulation (regulated) of B2 associated with morphine
4) Confidence 0.07 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0.05 Pain Relevance 0.35
Effects of the bradykinin B1 receptor antagonist des-Arg9[Leu8]bradykinin and genetic disruption of the B2 receptor on nociception in rats and mice.
Regulation (Effects) of B2 receptor associated with nociception, nociceptor, antagonist, b1 receptor, b2 receptor and bradykinin
5) Confidence 0.06 Published 1997 Journal Pain Section Title Doc Link 9200178 Disease Relevance 0.97 Pain Relevance 1.37
There were two previous observations which prompted us to study the effect of Dp71 depletion on BRB integrity.
Regulation (effect) of BRB
6) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.64 Pain Relevance 0.25
These findings indicate a key role for glial Dp71 in the maintenance of retinal potassium and water homeostasis and cellular volume regulation, as well as in the control of the BRB.
Regulation (control) of BRB
7) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.16 Pain Relevance 0.04
Effects of nicotine on kinin B1 and B2 receptor-mediated airway relaxations
Regulation (Effects) of B2 receptor associated with nicotine and b2 receptor
8) Confidence 0.01 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0 Pain Relevance 0.75
Effects of nicotine on airway kinin B1 and B2 receptor mRNA and protein expressions
Regulation (Effects) of B2 receptor mRNA associated with nicotine and b2 receptor
9) Confidence 0.01 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0 Pain Relevance 0.45
The presented results show that nicotine up-regulated kinin B1 and B2 receptor-mediated airway contractions, leaving 5-HT, cholinergic and endothelin receptor-mediated contractions completely unaffected.
Regulation (regulated) of B2 receptor associated with nicotine and b2 receptor
10) Confidence 0.01 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.29 Pain Relevance 0.47

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