INT70138

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Context Info
Confidence 0.41
First Reported 1997
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.31
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex assembly (Ccnb1) cytoplasm (Ccnb1) mitosis (Ccnb1)
nucleus (Ccnb1) cytoskeleton (Ccnb1) cell cycle (Ccnb1)
Anatomy Link Frequency
lungs 2
limb 1
Ccnb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 26 99.00 Very High Very High Very High
bradykinin 8 98.76 Very High Very High Very High
Arthritis 1 98.60 Very High Very High Very High
agonist 2 98.34 Very High Very High Very High
B1 receptor 4 98.18 Very High Very High Very High
Hyperalgesia 5 97.12 Very High Very High Very High
Inflammation 7 75.52 Quite High
antagonist 3 75.00 Quite High
b2 receptor 1 75.00 Quite High
Thermal hyperalgesia 1 60.56 Quite High
Disease Link Frequency Relevance Heat
Papillomavirus Infection 42 99.78 Very High Very High Very High
Skin Cancer 15 99.70 Very High Very High Very High
Cancer 82 99.44 Very High Very High Very High
Leukemia 3 99.42 Very High Very High Very High
Lymphatic System Cancer 3 99.22 Very High Very High Very High
Arthritis 1 98.60 Very High Very High Very High
Hyperalgesia 6 97.12 Very High Very High Very High
Nociception 5 96.00 Very High Very High Very High
Retinoblastoma 2 95.80 Very High Very High Very High
Cervical Cancer 27 91.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, we observed significant upregulation of known FoxM1 targets, including Plk1, Cenp-a, Birc5/survivin, and Ccnb1 (Fig. 2).
Positive_regulation (upregulation) of Ccnb1
1) Confidence 0.41 Published 2008 Journal Diabetes Section Body Doc Link PMC2570403 Disease Relevance 0.12 Pain Relevance 0
Consistent with the induction of proliferation observed by immunohistochemistry (Fig. 3), transcripts for genes that promote cell cycle progression, including Foxm1, cyclin A2, cyclin B1, cyclin D1, and cyclin E1, were increased in lungs of CCSPrtTA/tetO-Sox17 mice after 3 days of Dox treatment (Fig. 5).
Positive_regulation (increased) of cyclin B1 in lungs
2) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
Studies in different human tumors and cell lines including breast, lung, colorectal, lymphoma, leukemia, and melanoma have detected increased levels of cyclin B1 at both protein and mRNA [39].
Positive_regulation (increased) of cyclin B1 in lung associated with leukemia, lymphatic system cancer, cancer and skin cancer
3) Confidence 0.26 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 0.65 Pain Relevance 0
The abnormally increased cyclin B1 level previously found in human tumors has been shown to correlate with either mutation or deletion of p53 function [40].
Positive_regulation (increased) of cyclin B1 associated with cancer
4) Confidence 0.26 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 0.49 Pain Relevance 0
For example, HPV-positive cancers, compared to HPV-negative, upregulated a much larger set of cell cycle-specific genes such cyclin E2 (G1 associated), cyclin B1 (G2 associated) and multiple MCMs [50].
Positive_regulation (upregulated) of cyclin B1 associated with papillomavirus infection and cancer
5) Confidence 0.17 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 1.40 Pain Relevance 0
Upregulation of cyclinB1 also points to the G2/M checkpoint, which depends on cdk2/cyclinB1 activity.
Positive_regulation (Upregulation) of cyclinB1
6) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748684 Disease Relevance 0.52 Pain Relevance 0.09
In rats with monoarthritis, des-Arg9[Leu8]bradykinin (up to 30 nmol/kg i.v.) failed to reduce the number of vocalisations elicited by gentle flexion and extension of the inflamed limb; however, hyperalgesia was exacerbated by administration of the B1 receptor agonist des-[Arg9]bradykinin (100 nmol/kg i.v.), consistent with other evidence for local induction of B1 receptors during adjuvant-induced arthritis.
Positive_regulation (induction) of B1 in limb associated with hyperalgesia, b1 receptor, agonist, bradykinin and arthritis
7) Confidence 0.01 Published 1997 Journal Pain Section Abstract Doc Link 9200178 Disease Relevance 1.12 Pain Relevance 1.17

General Comments

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