INT70139

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Context Info
Confidence 0.52
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 11
Disease Relevance 8.41
Pain Relevance 6.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Bdkrb1) plasma membrane (Bdkrb1) signal transducer activity (Bdkrb1)
Anatomy Link Frequency
paw 1
Bdkrb1 (Mus musculus)
Pain Link Frequency Relevance Heat
bradykinin 289 100.00 Very High Very High Very High
B1 receptor 59 100.00 Very High Very High Very High
Pain 7 100.00 Very High Very High Very High
nociceptor 1 100.00 Very High Very High Very High
antagonist 60 99.96 Very High Very High Very High
Nicotine 576 99.94 Very High Very High Very High
cytokine 32 99.84 Very High Very High Very High
ischemia 16 99.60 Very High Very High Very High
Inflammation 192 99.18 Very High Very High Very High
Hyperalgesia 11 98.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 12 99.60 Very High Very High Very High
Diabetes Mellitus 11 99.32 Very High Very High Very High
INFLAMMATION 202 99.18 Very High Very High Very High
Hyperalgesia 13 98.64 Very High Very High Very High
Shock 1 98.12 Very High Very High Very High
Nociception 18 96.72 Very High Very High Very High
Autoimmune Disease 1 93.92 High High
Renal Disease 3 89.72 High High
Pain 2 89.56 High High
Pressure And Volume Under Development 15 89.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, PMA treatment did not alter B1 receptor mRNA levels, but greatly increased B1 receptor protein levels in the mouse paw.
Neg (not) Regulation (alter) of B1 receptor mRNA in paw associated with b1 receptor
1) Confidence 0.52 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18164734 Disease Relevance 0.82 Pain Relevance 0.76
Both bradykinin and des-Arg9-bradykinin elicits only negligible contractile responses in fresh segments and the culture procedure per se causes an up-regulation of the kinin receptors [20].
Regulation (regulation) of kinin associated with bradykinin
2) Confidence 0.26 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.07 Pain Relevance 0.37
Our results suggest a major influence of B1R in renal ischemia, since treatment with its antagonist resulted in functional improvement.
Regulation (influence) of B1R associated with antagonist and ischemia
3) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.47 Pain Relevance 0.71
Role of bradykinin B(1) receptors in diabetes-induced hyperalgesia in streptozotocin-treated mice.
Regulation (Role) of bradykinin B associated with hyperalgesia, diabetes mellitus and bradykinin
4) Confidence 0.23 Published 2002 Journal Eur. J. Pharmacol. Section Title Doc Link 12464357 Disease Relevance 1.56 Pain Relevance 0.63
Effects of the bradykinin B1 receptor antagonist des-Arg9[Leu8]bradykinin and genetic disruption of the B2 receptor on nociception in rats and mice.
Regulation (Effects) of B1 receptor associated with nociception, nociceptor, antagonist, b1 receptor, b2 receptor and bradykinin
5) Confidence 0.22 Published 1997 Journal Pain Section Title Doc Link 9200178 Disease Relevance 0.83 Pain Relevance 1.31
Thus, the present study was designed to investigate if long-term exposure to nicotine could induce AHR to bradykinin and des-Arg9-bradykinin through the selective up-regulation of kinin receptors and to explore the underlying intracellular inflammatory signal transduction mechanisms involved, with focus on both MAPK and PDE4.


Regulation (regulation) of kinin associated with inflammation, nicotine and bradykinin
6) Confidence 0.19 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.48 Pain Relevance 0.34
Our results show the simultaneous involvement of both JNK and PDE4/cAMP-mediated pathway in nicotine's effects on kinin receptors.
Regulation (effects) of kinin associated with nicotine
7) Confidence 0.19 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.13 Pain Relevance 0.48
One of the hypotheses of the present study is that long-term exposure to nicotine can induce activation of airway MAPK-mediated inflammatory signal pathways and subsequently cause AHR via up-regulation of kinin receptors.
Regulation (regulation) of kinin associated with inflammation and nicotine
8) Confidence 0.19 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.67 Pain Relevance 0.47
This is further corroborated by in vivo studies showing selective up-regulation of kinin receptors after exposure to cigarette smoke [8] and by in vitro results presenting activation of MAPK in human bronchial cells following stimulation of nicotinic receptors [9].
Regulation (regulation) of kinin
9) Confidence 0.19 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.61 Pain Relevance 0.48
B inflammatory signal pathways in AHR along with an up-regulation of kinin receptors [20,22,23].
Regulation (regulation) of kinin associated with inflammation
10) Confidence 0.19 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.62 Pain Relevance 0.44
The B1 receptor is generally expressed at low levels under normal conditions but is up-regulated by cytokines in stressful situations, such as shock and inflammation [5-7].
Regulation (regulated) of B1 receptor associated with inflammation, b1 receptor, shock and cytokine
11) Confidence 0.12 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 1.15 Pain Relevance 0.67

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