INT70145

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.76
First Reported 1997
Last Reported 2011
Negated 2
Speculated 4
Reported most in Body
Documents 136
Total Number 140
Disease Relevance 69.60
Pain Relevance 18.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 42
NK cells 5
DP thymocytes 4
pancreas 3
thymus 2
Trav6-3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1883 100.00 Very High Very High Very High
chemokine 447 100.00 Very High Very High Very High
Inflammatory response 129 100.00 Very High Very High Very High
Neuritis 137 99.92 Very High Very High Very High
Arthritis 694 99.68 Very High Very High Very High
Osteoarthritis 251 99.64 Very High Very High Very High
Inflammation 1565 99.58 Very High Very High Very High
rheumatoid arthritis 1726 99.50 Very High Very High Very High
Spinal cord 118 97.80 Very High Very High Very High
qutenza 6 97.46 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1709 100.00 Very High Very High Very High
Targeted Disruption 317 100.00 Very High Very High Very High
Influenza Virus Infection 253 100.00 Very High Very High Very High
Respiratory Syncytial Virus 66 100.00 Very High Very High Very High
Lymphatic System Cancer 755 99.98 Very High Very High Very High
Neuritis 11 99.92 Very High Very High Very High
Disease 1592 99.84 Very High Very High Very High
Arthritis 666 99.68 Very High Very High Very High
Osteoarthritis 251 99.64 Very High Very High Very High
Tick Infestations 24 99.58 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, reduction of TCR expression may provide a potential therapy for self-reactive T cells involved in autoimmune diseases through the induction of anergy.
Gene_expression (expression) of TCR in T cells associated with autoimmune disease
1) Confidence 0.76 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18490725 Disease Relevance 0.63 Pain Relevance 0.10
These cells have a dramatic Ab dose-dependent reduction in proliferation, with a small reduction in TCR expression leading to a 50% reduction in proliferation in vitro.
Gene_expression (expression) of TCR
2) Confidence 0.76 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18490725 Disease Relevance 0.27 Pain Relevance 0
Previous studies have found that a 95% reduction in TCR expression does not adversely affect response to foreign Ags, indicating that T cells have an excess of TCR for Ag recognition.
Gene_expression (expression) of TCR in T cells associated with alagille syndrome
3) Confidence 0.76 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18490725 Disease Relevance 0.17 Pain Relevance 0
In contrast, a diverse expression of TCR Vbeta genes was noted at 25 wk.
Gene_expression (expression) of TCR
4) Confidence 0.75 Published 1997 Journal J. Immunol. Section Abstract Doc Link 9200482 Disease Relevance 0.43 Pain Relevance 0.06
METHODS: Using intravital microscopy we examined the ocular inflammatory response after the onset of arthritis in mice that overexpressed the T cell receptor (TCR) specific for a dominant arthritogenic epitope of cartilage proteoglycan [TCR-Tg (transgenic) mice] or BALB/c controls.
Gene_expression (overexpressed) of TCR in T cell
5) Confidence 0.73 Published 2008 Journal Ophthalmic Res. Section Body Doc Link 18421237 Disease Relevance 0.19 Pain Relevance 0
After masking the TCR with either continuous or prepulsed anti-Valpha3.2 Ab, 2D2 cells were immediately stimulated with myelin oligodendrocyte glycoprotein (MOG)(35-55).
Gene_expression (masking) of TCR in oligodendrocyte
6) Confidence 0.66 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18490725 Disease Relevance 0.18 Pain Relevance 0
Lymphomas were characterized by FACS in order to determine the expression of CD4, CD8, the TCR?
Spec (determine) Gene_expression (expression) of TCR associated with lymphatic system cancer
7) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 0.68 Pain Relevance 0
These results show that bacterial Sags upregulate the expression of Fas and Fas-L on lymphoma T cells expressing the appropriate TCR V?
Gene_expression (expressing) of TCR in T cells associated with lymphatic system cancer
8) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 0.90 Pain Relevance 0
rearrangement, and test the newly generated TCR?
Gene_expression (generated) of TCR
9) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.06 Pain Relevance 0
Useful TCR interactions will result in positive selection of the cell, upregulation of TCR and CD69 surface expression, and lineage commitment of CD4 SP and CD8 SP thymocytes.
Gene_expression (expression) of TCR in thymocytes
10) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.08 Pain Relevance 0
Similarly, T cells from transgenic animals expressing the cognate TCR are dye-labeled with 5-(and-6)-carboxyfluorescein diacetate succinimidyl ester (CSFE) or 5-(and-6)-(((4-chloromethyl) benzoyl) amino) tetramethylrhodamine (CMTMR) and injected intravenously (for a more extensive list of dyes that can be used for intravital microscopy, see the review by Cahalan and colleagues [16]).
Gene_expression (expressing) of TCR in T cells associated with targeted disruption
11) Confidence 0.23 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297591 Disease Relevance 0.24 Pain Relevance 0.08
We found that twenty eight of 38 (74%) AKR/J spontaneous lymphomas expressed TCR?
Gene_expression (expressed) of TCR associated with lymphatic system cancer
12) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 1.03 Pain Relevance 0.06
The capacity of bacterial Sags to induce the activation and deletion of T cells expressing T cell receptors (TCR) with a specific subset of TCR ?
Gene_expression (expressing) of TCR in T cell
13) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 0.44 Pain Relevance 0
Six of 28 lymphomas expressing the TCR?
Gene_expression (expressing) of TCR associated with lymphatic system cancer
14) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 1.05 Pain Relevance 0.06
It has been extensively reported that the interaction of Sags with normal T lymphocytes expressing particular TCR V?
Gene_expression (expressing) of TCR in T lymphocytes
15) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 0.82 Pain Relevance 0
Sags bind to major histocompatibility complex (MHC) class II molecules as unprocessed proteins and subsequently interact with a high number of T cells expressing particular T cell receptor (TCR) V?
Gene_expression (expressing) of TCR in T cell
16) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 0.35 Pain Relevance 0
PTPH1 overexpression in Jurkat T cells reduces indirectly the TCR-induced serine phosphorylation of Mek, Erk, Jnk and AP-1 leading to a decreased IL-2 gene activation [13].
Gene_expression (reduces) of TCR in T cells
17) Confidence 0.22 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2873500 Disease Relevance 0.23 Pain Relevance 0.04
Thus, the development of TCR?
Gene_expression (development) of TCR
18) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.16 Pain Relevance 0
We observed that the DPdull (CD4lowCD8low) thymocytes, a sub-population of DP thymocytes that are normally enriched for selected TCR?
Gene_expression (selected) of TCR in DP thymocytes
19) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.09 Pain Relevance 0
We observed that the DPdull (CD4lowCD8low) thymocytes, a sub-population of DP thymocytes that are normally enriched for selected TCR?
Gene_expression (enriched) of TCR in DP thymocytes
20) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.09 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox