INT7017

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Context Info
Confidence 0.52
First Reported 1980
Last Reported 2009
Negated 11
Speculated 2
Reported most in Abstract
Documents 45
Total Number 47
Disease Relevance 3.38
Pain Relevance 20.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Npr1) intracellular (Npr1)
Anatomy Link Frequency
brain 5
striatum 2
Plasma 1
myocardium 1
ileum 1
Npr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 44 100.00 Very High Very High Very High
Dopamine 31 100.00 Very High Very High Very High
opiate 28 100.00 Very High Very High Very High
Clonidine 23 100.00 Very High Very High Very High
lidocaine 5 100.00 Very High Very High Very High
Opioid 21 99.98 Very High Very High Very High
qutenza 6 99.84 Very High Very High Very High
Catecholamine 3 99.84 Very High Very High Very High
tolerance 6 99.78 Very High Very High Very High
agonist 42 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypertrophy 1 99.50 Very High Very High Very High
Diabetes Mellitus 5 98.72 Very High Very High Very High
Adrenal Cancer 8 98.24 Very High Very High Very High
Vibrio Infection 3 98.10 Very High Very High Very High
Urological Neuroanatomy 5 98.08 Very High Very High Very High
Nociception 4 97.36 Very High Very High Very High
Hypotension 1 96.16 Very High Very High Very High
Obesity 13 88.52 High High
Opiate Addiction 2 81.72 Quite High
Bordatella Infection 3 79.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate a dual regulation of guanylate cyclase and adenylate cyclase by the alpha 2-receptor signal: guanylate cyclase is coupled to the receptor in a positive fashion, whereas adenylate cyclase is coupled in a negative fashion.
Regulation (regulation) of cyclase
1) Confidence 0.52 Published 1986 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 2875690 Disease Relevance 0.14 Pain Relevance 0.31
Dual regulation of adenylate cyclase and guanylate cyclase: alpha 2-adrenergic signal transduction in adrenocortical carcinoma cells.
Regulation (regulation) of cyclase associated with adrenal cancer
2) Confidence 0.52 Published 1986 Journal Arch. Biochem. Biophys. Section Title Doc Link 2875690 Disease Relevance 0.19 Pain Relevance 0.33
These results indicate a dual regulation of guanylate cyclase and adenylate cyclase by the alpha 2-receptor signal: guanylate cyclase is coupled to the receptor in a positive fashion, whereas adenylate cyclase is coupled in a negative fashion.
Regulation (regulation) of cyclase
3) Confidence 0.52 Published 1986 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 2875690 Disease Relevance 0.14 Pain Relevance 0.31
Dual regulation of adenylate cyclase and guanylate cyclase: alpha 2-adrenergic signal transduction in adrenocortical carcinoma cells.
Regulation (regulation) of cyclase associated with adrenal cancer
4) Confidence 0.52 Published 1986 Journal Arch. Biochem. Biophys. Section Title Doc Link 2875690 Disease Relevance 0.19 Pain Relevance 0.32
OBJECTIVES: To observe the changes of adenylate cyclase (AC) and guanylate cyclase (GC) in the cerebral regions including the locus ceruleus, periaqueductal gray, and substantia nigra in rats that were physiologically dependent on morphine.
Regulation (changes) of guanylate cyclase in substantia nigra associated with substantia nigra, locus ceruleus, central grey and morphine
5) Confidence 0.27 Published 2009 Journal Am J Drug Alcohol Abuse Section Abstract Doc Link 19353384 Disease Relevance 0.17 Pain Relevance 0.55
Most of the drugs that are active are known to increase neural levels of cyclic GMP either by acting on guanylate cyclase or on phosphodiesterase.
Regulation (acting) of guanylate cyclase in neural
6) Confidence 0.25 Published 1986 Journal Neurosci Biobehav Rev Section Abstract Doc Link 2871535 Disease Relevance 0 Pain Relevance 0.40
The regulation of bile acid transport in rat ileum was studied in vitro using the adenylate cyclase stimulator forskolin, or 3-isobutyl-1-methylxanthine (IBMX), a phosphodiesterase inhibitor.
Regulation (using) of cyclase in ileum associated with bile
7) Confidence 0.21 Published 1989 Journal Biochim. Biophys. Acta Section Abstract Doc Link 2469477 Disease Relevance 0 Pain Relevance 0.09
The effects of lithium on the activity of adenylate cyclase stimulated by hormones, which act via the stimulatory guanine nucleotide binding subunit (Ns), by forskolin, which acts at the catalytic subunit, and by guanyl-5'-yl imidodiphosphate (GppNHp), which locks the enzyme into a permanently active state, have been compared in a preparation of membranes from the cerebral cortex of the rat.
Regulation (effects) of cyclase in cerebral cortex associated with cerebral cortex
8) Confidence 0.21 Published 1987 Journal Neuropharmacology Section Abstract Doc Link 3035412 Disease Relevance 0 Pain Relevance 0.14
Moving more distally in the NOS-guanylyl cyclase signaling pathway, we investigated the effects of the specific soluble guanylyl cyclase inhibitor ODQ, 1H-(1,2,4)oxadiazolo[4,3-a]quinoxalin-1-one, on anesthetic requirements.
Spec (investigated) Regulation (effects) of cyclase
9) Confidence 0.18 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15333406 Disease Relevance 0 Pain Relevance 0.53
Further analysis of naltrexone's mode of action was obtained by studying its effect on the adenylate cyclase activity.
Regulation (effect) of cyclase
10) Confidence 0.17 Published 1989 Journal J. Neurosci. Res. Section Abstract Doc Link 2540341 Disease Relevance 0 Pain Relevance 0.60
Naltrexone had no significant effect on the basal adenylate cyclase activity but it altered the pattern of cyclic AMP formation in isoproterenol-stimulated cultures.
Neg (no) Regulation (effect) of cyclase
11) Confidence 0.17 Published 1989 Journal J. Neurosci. Res. Section Abstract Doc Link 2540341 Disease Relevance 0 Pain Relevance 0.59
Thus chronic D1 blockade, like chronic morphine treatment, appears to cause a selective impairment of the regulation of adenylyl cyclase in A2a receptor-expressing striato-pallidal neurons.
Regulation (regulation) of cyclase in neurons associated with morphine
12) Confidence 0.17 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9353370 Disease Relevance 0 Pain Relevance 1.03
Superfusion of the ventral striatum with the guanylyl cyclase inhibitor LY83583 decreased acetylcholine release by 60% of basal release, whereas the less specific guanylyl cyclase inhibitor methylene blue was ineffective in this respect.
Regulation (ineffective) of cyclase in striatum
13) Confidence 0.14 Published 1995 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7477427 Disease Relevance 0 Pain Relevance 0.09
Infusions of phenylephrine and clonidine had no effect on adenylate cyclase responsiveness.
Neg (no) Regulation (effect) of cyclase associated with clonidine
14) Confidence 0.09 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2838602 Disease Relevance 0.44 Pain Relevance 0.10
Low concentrations (up to 30 nM) of the nucleotide increase activity whereas higher concentrations evoke a steady decline in activity; such behavior characterizes dually regulated adenylate cyclase systems.
Regulation (regulated) of cyclase
15) Confidence 0.08 Published 1982 Journal J. Neurochem. Section Abstract Doc Link 6278084 Disease Relevance 0 Pain Relevance 0.67
Both peptides were shown a) to bind with high affinity to the opiate receptors of rat brain membranes and b) to inhibit strongly the contractions of electrically stimulated vas deferens and the adenyl cyclase of the NG 108-15 cell membranes.
Regulation (contractions) of cyclase in vas deferens associated with opiate
16) Confidence 0.08 Published 1982 Journal Life Sci. Section Abstract Doc Link 6296569 Disease Relevance 0 Pain Relevance 0.62
METHODS: The authors have examined the effects of an NO synthase inhibitor and a soluble guanylate cyclase inhibitor on the concentrations of NO metabolites (NO2-/NO3-) and glutamate in the cerebrospinal fluid after intrathecal perfusion of NMDA, concomitantly observing pain-related behavior (scratching, biting, and vocalization) in unanesthetized, free-moving rats using an intrathecal microdialysis method.
Spec (examined) Regulation (effects) of cyclase in cerebrospinal fluid
17) Confidence 0.08 Published 1999 Journal Anesthesiology Section Body Doc Link 10551594 Disease Relevance 0.10 Pain Relevance 0
The kappa-agonist, U 50,488, did not affect DA- or D1 receptor-stimulated adenylate cyclase activity in any of the brain regions.
Neg (not) Regulation (affect) of cyclase in brain associated with dopamine and agonist
18) Confidence 0.07 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1337044 Disease Relevance 0.07 Pain Relevance 1.13
Our results suggest a role for pituitary and/or brain somatostatin in the physiological regulation of the intermediate pituitary lobe, and the possibility of an interaction between somatostatins and catecholamines on the regulation of intermediate lobe adenylate cyclase.
Regulation (regulation) of cyclase in pituitary associated with catecholamine and somatostatin
19) Confidence 0.07 Published 1983 Journal Neuroendocrinology Section Abstract Doc Link 6138724 Disease Relevance 0 Pain Relevance 0.43
The adaptive changes in D1 DA and delta receptor-regulated adenylate cyclase activity are discussed in relation to the well-known increase in the locomotor and reinforcing effects of mu-opioid receptor agonists upon chronic neuroleptic treatment.
Regulation (regulated) of cyclase associated with dopamine, agonist and opioid receptor
20) Confidence 0.06 Published 1994 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 7913003 Disease Relevance 0 Pain Relevance 0.71

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