INT70174

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Context Info
Confidence 0.42
First Reported 1997
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.88
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcg) plasma membrane (Prkcg) nucleus (Prkcg)
intracellular (Prkcg) response to stress (Prkcg) cytoplasm (Prkcg)
Anatomy Link Frequency
endothelium 2
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 44 100.00 Very High Very High Very High
agonist 8 100.00 Very High Very High Very High
Clonidine 2 100.00 Very High Very High Very High
adenocard 1 100.00 Very High Very High Very High
substance P 66 99.28 Very High Very High Very High
Hyperalgesia 5 98.96 Very High Very High Very High
nav1.8 65 97.12 Very High Very High Very High
dorsal root ganglion 43 94.72 High High
Action potential 10 68.32 Quite High
Hippocampus 24 55.56 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 5 98.96 Very High Very High Very High
Ganglion Cysts 45 94.72 High High
Sepsis 4 92.72 High High
Sprains And Strains 1 80.84 Quite High
Depression 1 48.40 Quite Low
Pain 13 5.00 Very Low Very Low Very Low
INFLAMMATION 11 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 6 5.00 Very Low Very Low Very Low
Nociception 3 5.00 Very Low Very Low Very Low
Inflammatory Pain 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Relaxation responses to the alpha 2-adrenoceptor agonist clonidine, the endothelium-dependent vasodilator adenosine 5'-diphosphate, and the PKC inhibitor staurosporine were reduced, but the relaxation to the endothelium-independent cyclic GMP-mediated vasodilator sodium nitroprusside was preserved.
Negative_regulation (reduced) of Regulation (responses) of PKC in endothelium associated with kinase c, adenocard, agonist and clonidine
1) Confidence 0.42 Published 1997 Journal J. Surg. Res. Section Abstract Doc Link 9202648 Disease Relevance 0.40 Pain Relevance 0.51
Therefore, to explore the effect of PKC?
Negative_regulation (explore) of Regulation (effect) of PKC associated with kinase c
2) Confidence 0.21 Published 2009 Journal Mol Pain Section Body Doc Link PMC2715383 Disease Relevance 0.48 Pain Relevance 1.34
Furthermore, we observed a substantial reduction in the dADP amplitude in response to PKC activation which is consistent with the report that in HEK cells, TRPC5 channels are desensitized by PKC phosphorylation of T972 located in the C-terminal region [44],[45],[46].
Negative_regulation (reduction) of Regulation (response) of PKC
3) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.13

General Comments

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