INT7018

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Context Info
Confidence 0.59
First Reported 1992
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 5.09
Pain Relevance 5.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Npr1) intracellular (Npr1)
Anatomy Link Frequency
BNP 6
spinal cord 4
pituitary 4
spinal 2
dorsal root ganglion 2
Npr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 22 100.00 Very High Very High Very High
opioid receptor 2 100.00 Very High Very High Very High
opiate 6 99.98 Very High Very High Very High
nMDA receptor 5 99.64 Very High Very High Very High
Inflammation 16 99.60 Very High Very High Very High
Dopamine 9 99.58 Very High Very High Very High
Spinal cord 30 99.40 Very High Very High Very High
spinal dorsal horn 13 99.40 Very High Very High Very High
intrathecal 8 99.32 Very High Very High Very High
Opioid 4 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 22 100.00 Very High Very High Very High
Natriuresis 18 100.00 Very High Very High Very High
INFLAMMATION 8 99.60 Very High Very High Very High
Coronary Heart Disease 12 98.72 Very High Very High Very High
Opiate Addiction 5 97.44 Very High Very High Very High
Pain 6 96.92 Very High Very High Very High
Fibrosis 7 93.88 High High
Hyperalgesia 10 93.48 High High
Inflammatory Pain 4 92.92 High High
Stress Incontinence 2 88.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased natriuretic peptide receptor A and C gene expression in rats with pressure-overload cardiac hypertrophy.
Positive_regulation (Increased) of Gene_expression (expression) of natriuretic peptide receptor associated with natriuresis and coronary heart disease
1) Confidence 0.59 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Title Doc Link 16272201 Disease Relevance 0.90 Pain Relevance 0.23
During formalin-induced long-lasting inflammation, we found that the expression of the alpha(1) subunit of soluble guanylate cyclase was dramatically increased in the lumbar spinal cord on the second and fourth days after formalin injection into the dorsal side of a hind paw.
Positive_regulation (increased) of Gene_expression (expression) of cyclase in spinal cord associated with inflammation and spinal cord
2) Confidence 0.58 Published 2002 Journal Neuroscience Section Abstract Doc Link 12044461 Disease Relevance 0.55 Pain Relevance 0.74
The present results indicate that peripheral inflammation not only initially activates but also later up-regulates soluble guanylate cyclase expression via the NMDA receptor-NO signaling pathway, suggesting that soluble guanylate cyclase might be involved in the central mechanism of formalin-induced inflammatory hyperalgesia in the spinal cord.
Positive_regulation (up-regulates) of Gene_expression (expression) of cyclase in spinal cord associated with hyperalgesia, inflammation, nmda receptor and spinal cord
3) Confidence 0.58 Published 2002 Journal Neuroscience Section Abstract Doc Link 12044461 Disease Relevance 0.58 Pain Relevance 0.76
Aortic banding increased left ventricular expression of NPR-A and NPR-C mRNA by 110% (P < 0.001) and 520% (P < 0.01), respectively, after 8 wk; as expected, it also increased the expression of ANP and BNP mRNAs.
Positive_regulation (increased) of Gene_expression (expression) of NPR in BNP
4) Confidence 0.49 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16272201 Disease Relevance 0.83 Pain Relevance 0.26
Aortic banding increased left ventricular expression of NPR-A and NPR-C mRNA by 110% (P < 0.001) and 520% (P < 0.01), respectively, after 8 wk; as expected, it also increased the expression of ANP and BNP mRNAs.
Positive_regulation (increased) of Gene_expression (expression) of NPR in BNP
5) Confidence 0.49 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16272201 Disease Relevance 0.82 Pain Relevance 0.26
Using microarray and immunoblot analyses, we found that BNP and NPR-A were expressed in the dorsal root ganglion (DRG) of rats and upregulated after intraplantar injection of complete Freund's adjuvant (CFA).
Positive_regulation (upregulated) of Gene_expression (expressed) of NPR-A in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
6) Confidence 0.45 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20702721 Disease Relevance 0.91 Pain Relevance 0.60
When extracts from the urinary bladder were fractionated by reverse phase high pressure liquid chromatography immunoreactive components corresponding to synthetic pituitary adenylate cyclase activating peptide-38, pituitary adenylate cyclase activating peptide-27 and pituitary adenylate cyclase activating peptide-related peptide were identified with the respective antisera.
Positive_regulation (activating) of Gene_expression (synthetic) of cyclase in pituitary
7) Confidence 0.16 Published 1998 Journal Neuroscience Section Abstract Doc Link 9502264 Disease Relevance 0.09 Pain Relevance 0.07
When extracts from the urinary bladder were fractionated by reverse phase high pressure liquid chromatography immunoreactive components corresponding to synthetic pituitary adenylate cyclase activating peptide-38, pituitary adenylate cyclase activating peptide-27 and pituitary adenylate cyclase activating peptide-related peptide were identified with the respective antisera.
Positive_regulation (activating) of Gene_expression (synthetic) of cyclase in pituitary
8) Confidence 0.16 Published 1998 Journal Neuroscience Section Abstract Doc Link 9502264 Disease Relevance 0.09 Pain Relevance 0.07
Therefore, in nucleus accumbens opioids may inhibit DA-sensitive adenylate cyclase through activation of a mu/delta-opioid receptor complex, whereas in olfactory tubercle mu-receptors appear to mediate the inhibition of adenylate cyclase activity.
Spec (appear) Positive_regulation (mediate) of Spec (appear) Gene_expression (appear) of cyclase in olfactory tubercle associated with nucleus accumbens, dopamine, opioid receptor and opioid
9) Confidence 0.14 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1337044 Disease Relevance 0 Pain Relevance 1.09
We have found that chronic opiates increase levels of the G-protein subunits Gi alpha and Go alpha, adenylate cyclase, cyclic AMP-dependent protein kinase, and a number of phosphoproteins (including tyrosine hydroxylase) in this brain region.
Positive_regulation (increase) of Gene_expression (levels) of cyclase in brain associated with opiate
10) Confidence 0.11 Published 1993 Journal Neurochem. Res. Section Abstract Doc Link 8385277 Disease Relevance 0.17 Pain Relevance 0.70
Intrathecal administration of NMDA causes an increase in cGMP, a production of NO target guanylate cyclase (sGC), in the spinal dorsal horn [28].
Positive_regulation (increase) of Gene_expression (production) of cyclase in spinal associated with spinal dorsal horn and intrathecal
11) Confidence 0.03 Published 2010 Journal Mol Pain Section Body Doc Link PMC2826347 Disease Relevance 0.15 Pain Relevance 0.87

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