INT70181

Context Info Confidence 0.58 First Reported 1997 Last Reported 1997 Negated 1 Speculated 1 Reported most in Abstract Documents 1 Total Number 4 Disease Relevance 0.36 Pain Relevance 1.26

nucleoplasm (FOS) peptidase activity (PRCP) aging (FOS) nucleolus (FOS) nucleus (FOS) plasma membrane (PRCP)

Anatomy Link Frequency cortex 1 hippocampus 1 PRCP (Homo sapiens) FOS (Homo sapiens)

Pain Link Frequency Relevance Heat fortral 12 100.00 Hippocampus 4 99.68 Thalamus 4 98.92 Limbic system 4 98.88 nMDA receptor 4 95.60 antagonist 4 87.52

Disease Link Frequency Relevance Heat Schizophrenia 4 98.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It was also proposed that PCP may induce c-fos via the sigma receptor.

PCP Spec (may) Positive_regulation (induce) of c-fos

1) Confidence 0.58 Published 1997 Journal Brain Res. Section Abstract Doc Link 9203533 Disease Relevance 0.09 Pain Relevance 0.28

It was hypothesized that PCP induction of the immediate-early gene, c-fos, should be seen in areas associated with emotional behavior, such as the cortex and limbic system.

PCP Positive_regulation (induction) of c-fos in cortex associated with limbic system

2) Confidence 0.39 Published 1997 Journal Brain Res. Section Abstract Doc Link 9203533 Disease Relevance 0.10 Pain Relevance 0.22

PCP and two sigma ligands, 1,3-di(2-tolyl)guanidine (DTG) and pentazocine, were shown to induce c-fos in similar patterns.

PCP Positive_regulation (induce) of c-fos associated with fortral

3) Confidence 0.39 Published 1997 Journal Brain Res. Section Abstract Doc Link 9203533 Disease Relevance 0.09 Pain Relevance 0.31

Neither PCP nor the sigma ligands induced c-fos in the hippocampus.

PCP Neg (nor) Positive_regulation (induced) of c-fos in hippocampus associated with hippocampus

4) Confidence 0.39 Published 1997 Journal Brain Res. Section Abstract Doc Link 9203533 Disease Relevance 0.08 Pain Relevance 0.45

General Comments

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