INT70197

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Context Info
Confidence 0.24
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.61
Pain Relevance 2.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs1) nuclear envelope (Ptgs1) oxidoreductase activity (Ptgs1)
Golgi apparatus (Ptgs1) endoplasmic reticulum (Ptgs1) plasma membrane (Ptgs1)
Anatomy Link Frequency
poly 2
body 2
Ptgs1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 28 99.96 Very High Very High Very High
Inflammation 16 99.84 Very High Very High Very High
Paracetamol 11 99.48 Very High Very High Very High
Pyramidal cell 1 93.68 High High
Analgesic 1 93.56 High High
Pain 8 91.36 High High
antagonist 1 43.76 Quite Low
COX-2 inhibitor 4 36.24 Quite Low
COX2 3 25.00 Low Low
cOX1 2 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 27 99.84 Very High Very High Very High
Peptic Ulcer 3 98.88 Very High Very High Very High
Atherosclerosis 32 94.92 High High
Toxicity 2 94.48 High High
Neurodegenerative Disease 11 94.40 High High
Pain 7 91.36 High High
Ulcers 3 78.88 Quite High
Targeted Disruption 4 75.00 Quite High
Nociception 1 75.00 Quite High
Wound Healing 2 34.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While the development of selective inhibitors of inducible cyclooxygenase (COX)-2 (so called coxibs) has greatly reduced gastrointestinal side effects, the recent disappointment about a potential cardiovascular toxicity of COX-2-selective inhibitors has boosted interest in alternative targets.
Negative_regulation (inhibitors) of Positive_regulation (inducible) of cyclooxygenase associated with toxicity
1) Confidence 0.24 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 16959219 Disease Relevance 0.52 Pain Relevance 0.55
Traditional NSAIDs, selective cyclooxygenase (COX)-2 inhibitors, and inhibitors of nitric oxide synthase (NOS) impair the healing of preexisting gastric ulcers.
Negative_regulation (impair) of Positive_regulation (selective) of cyclooxygenase associated with cinod and peptic ulcer
2) Confidence 0.13 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16373427 Disease Relevance 0.45 Pain Relevance 0.10
Although the mechanism of action of acetaminophen (AAP) is not fully understood, some studies suggest that AAP and phenacetin (PHE) are selective cyclooxygenase (COX)-3 inhibitors.
Negative_regulation (inhibitors) of Positive_regulation (selective) of cyclooxygenase associated with paracetamol
3) Confidence 0.10 Published 2007 Journal J. Psychopharmacol. (Oxford) Section Abstract Doc Link 17606472 Disease Relevance 0 Pain Relevance 0.60
This year many papers have been published speculating about those NSAIDs that are reported to selectively inhibit the isoform of the cyclooxygenase enzyme that is induced in inflammatory conditions (Cox-2) rather than that associated with normal physiologic function (Cox-1).
Negative_regulation (inhibit) of Positive_regulation (induced) of cyclooxygenase associated with inflammation and cinod
4) Confidence 0.07 Published 1997 Journal Curr Opin Rheumatol Section Abstract Doc Link 9204251 Disease Relevance 0.57 Pain Relevance 0.53
Treatment with the nonselective cyclooxygenase (COX) inhibitor carprofen prevents poly(I ? 
Negative_regulation (inhibitor) of Positive_regulation (nonselective) of cyclooxygenase in poly
5) Confidence 0.05 Published 2010 Journal mBio Section Body Doc Link PMC2953007 Disease Relevance 0.46 Pain Relevance 0.23
Loxoprofen sodium, a non-selective NSAID, becomes active after metabolism in the body and inhibits the activation of cyclooxygenase.
Negative_regulation (inhibits) of Positive_regulation (activation) of cyclooxygenase in body associated with cinod
6) Confidence 0.05 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Abstract Doc Link PMC2935154 Disease Relevance 0.61 Pain Relevance 0.45

General Comments

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