INT7020

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Context Info
Confidence 0.57
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 25
Total Number 25
Disease Relevance 1.84
Pain Relevance 17.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Drd1a) plasma membrane (Drd1a) nucleus (Drd1a)
intracellular (Drd1a) signal transducer activity (Drd1a)
Anatomy Link Frequency
neurons 2
neuronal 1
hypothalamus 1
paw 1
spinal cord 1
Drd1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 616 100.00 Very High Very High Very High
antagonist 101 100.00 Very High Very High Very High
agonist 85 100.00 Very High Very High Very High
dopamine receptor 72 100.00 Very High Very High Very High
Enkephalin 20 99.82 Very High Very High Very High
narcan 7 99.82 Very High Very High Very High
opioid receptor 16 99.68 Very High Very High Very High
Morphine 22 99.60 Very High Very High Very High
analgesia 9 99.52 Very High Very High Very High
dexamethasone 3 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 76 98.80 Very High Very High Very High
Pain 10 97.50 Very High Very High Very High
Nociception 10 97.08 Very High Very High Very High
Urological Neuroanatomy 8 95.80 Very High Very High Very High
INFLAMMATION 1 94.36 High High
Attention Deficit Hyperactivity Disorder 17 89.88 High High
Schizophrenia 245 78.64 Quite High
Targeted Disruption 3 75.36 Quite High
Depression 8 69.56 Quite High
Cognitive Disorder 11 64.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The major changes found were an increased D-1 receptor stimulated cAMP production and an enhanced release of noradrenaline in morphine treated rats and a decreased D-1 receptor stimulated cAMP production in naltrexone treated rats.
Negative_regulation (decreased) of D-1 receptor associated with noradrenaline and morphine
1) Confidence 0.57 Published 1993 Journal Life Sci. Section Abstract Doc Link 8388977 Disease Relevance 0 Pain Relevance 1.02
The D1-receptor mRNA was decreased in the caudorostral striatum during cocaine withdrawal, a finding opposite to the increase observed following a single injection of the drug.
Negative_regulation (decreased) of D1-receptor in striatum associated with withdrawal and cocaine
2) Confidence 0.54 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602109 Disease Relevance 0 Pain Relevance 0.76
These results show long-term suppression on prodynorphin and D1-receptor systems in specific striatal populations localized mainly in rostral areas during withdrawal from cocaine.
Negative_regulation (suppression) of D1-receptor associated with withdrawal and cocaine
3) Confidence 0.54 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602109 Disease Relevance 0 Pain Relevance 0.66
Specific reductions of striatal prodynorphin and D1 dopamine receptor messenger RNAs during cocaine abstinence.
Negative_regulation (reductions) of D1 dopamine receptor associated with dopamine receptor, enkephalin and cocaine
4) Confidence 0.54 Published 1998 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9602109 Disease Relevance 0 Pain Relevance 0.91
The ability of the mu agonist DAMGO to inhibit the dopamine D-1 receptor stimulated cAMP production in striatal slices and the electrically evoked release of [3H]noradrenaline from cortical slices was unaffected in both experimental groups.
Negative_regulation (inhibit) of D-1 receptor associated with dopamine, noradrenaline and agonist
5) Confidence 0.50 Published 1993 Journal Life Sci. Section Abstract Doc Link 8388977 Disease Relevance 0 Pain Relevance 0.94
The attenuation of heroin intake during initiation of heroin self-administration by blockade of dopamine D1 receptor systems may be due to a decrease in the reinforcing effects of heroin or more likely to a reduction in non-reinforcement-related behavior.
Negative_regulation (blockade) of dopamine D1 receptor associated with dopamine
6) Confidence 0.43 Published 1994 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7855207 Disease Relevance 0 Pain Relevance 0.62
Dopamine D1 receptor agonist-induced grooming is blocked by the opioid receptor antagonist naloxone.
Negative_regulation (blocked) of D1 receptor associated with dopamine, antagonist, narcan, agonist and opioid receptor
7) Confidence 0.40 Published 1994 Journal Eur. J. Pharmacol. Section Title Doc Link 7982457 Disease Relevance 0 Pain Relevance 0.73
D1 dopamine receptor-stimulated adenylate cyclase activity was also slightly reduced (by approximately 20%) by high concentrations of the kappa-agonist U50,488 (EC50 = 0.63 microM).
Negative_regulation (reduced) of D1 dopamine receptor-stimulated associated with dopamine receptor and agonist
8) Confidence 0.39 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2168934 Disease Relevance 0 Pain Relevance 1.02
The receptors mediating the inhibition of D1 dopamine receptor-stimulated adenylate cyclase by opioids were examined in primary cultures of rat neostriatal neurons.
Negative_regulation (inhibition) of D1 dopamine receptor-stimulated in neurons associated with dopamine receptor and opioid
9) Confidence 0.39 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2168934 Disease Relevance 0 Pain Relevance 0.58
Repeated treatment with FNM also resulted in statistically significant increases in D2 dopamine receptor mRNA but decreases in D1 dopamine receptor mRNA.
Negative_regulation (decreases) of D1 dopamine receptor mRNA associated with dopamine receptor
10) Confidence 0.37 Published 1994 Journal Neurochem. Int. Section Abstract Doc Link 7820070 Disease Relevance 0 Pain Relevance 0.81
In both morphine-treated and untreated neurons, low concentrations (< .3 nM) of corticosterone or aldosterone, but not dexamethasone, caused a slight (about 20%) reduction of dopamine D-1 receptor-stimulated adenylyl cyclase activity, indicating the involvement of mineralocorticoid receptors.
Negative_regulation (reduction) of D-1 receptor in neurons associated with dopamine, dexamethasone and morphine
11) Confidence 0.34 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7562482 Disease Relevance 0 Pain Relevance 1.10
The results suggest that D2 receptor is involved in pain modulation and activation of D2 receptor and enhances AA in the spinal cord, while such effect is absent in D1 receptor and inactivation of D1 receptor attenuates AA.
Negative_regulation (inactivation) of D1 receptor in spinal cord associated with pain, spinal cord and analgesia
12) Confidence 0.30 Published 1998 Journal Sheng Li Xue Bao Section Abstract Doc Link 11324516 Disease Relevance 0.34 Pain Relevance 1.67
The neuropeptide cholecystokinin (CCK) has been shown to interact with dopamine in various ways, including attenuation of dopamine D1 receptor-mediated vacuous chewing and grooming.
Negative_regulation (attenuation) of dopamine D1 associated with dopamine, neuropeptide and cholecystokinin
13) Confidence 0.27 Published 1997 Journal Neuropharmacology Section Abstract Doc Link 9517439 Disease Relevance 0 Pain Relevance 0.73
The reduction in reinstatement caused by blocking dopamine D1 receptors in the NAc core in the present study may also be attributable to an effect on responding for the discrete stimulus.
Negative_regulation (blocking) of dopamine D1 associated with nucleus accumbens and dopamine
14) Confidence 0.26 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2770635 Disease Relevance 0 Pain Relevance 0.21
g/side) in the NAc core indicates selectivity, at this dose, in the effects of blocking dopamine D1-like receptors in the core on reinstated EtOH seeking.
Negative_regulation (blocking) of dopamine D1 associated with nucleus accumbens and dopamine
15) Confidence 0.26 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2770635 Disease Relevance 0 Pain Relevance 0.40
The combined treatment down-regulated D1 receptor and enkephalin mRNA in accumbens.
Negative_regulation (regulated) of D1 receptor associated with enkephalin
16) Confidence 0.19 Published 2008 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 18570703 Disease Relevance 0.25 Pain Relevance 0.75
Injection of 5-hydroxytryptamine into the s.c. tissue of the hind paw of rats produced nociceptive flinch behavior and inflammatory cell migration, that were significantly reduced by the nonspecific selectin inhibitor fucoidan. 5-Hydroxytryptamine-induced nociception was also significantly reduced by local blockade of the 5-HT3 receptor by tropisetron, by the cyclooxygenase inhibitor indomethacin and by local blockade of the beta1-adrenergic receptor or of the D1 receptor by atenolol or SCH 23390, respectively.
Negative_regulation (blockade) of D1 receptor in paw associated with nociception and inflammation
17) Confidence 0.13 Published 2006 Journal Neuroscience Section Abstract Doc Link 16750893 Disease Relevance 0.65 Pain Relevance 0.26
Under normal conditions, SPD works as a D1 receptor antagonist, while in the 6-OHDA-induced PD model, SPD serves as a partial agonist.
Negative_regulation (antagonist) of D1 receptor associated with antagonist, agonist and disease
18) Confidence 0.12 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644490 Disease Relevance 0.10 Pain Relevance 0.21
In slices of rat nucleus accumbens, olfactory tubercle, frontal cortex and mediobasal hypothalamus exposed to dopamine (DA), the activation of DA D1 receptors stimulated cyclic AMP (cAMP) formation whereas, in nucleus accumbens slices only, activation of D2 receptors appeared to inhibit D1 receptor-stimulated adenylate cyclase at the same time.
Negative_regulation (inhibit) of D1 receptor in hypothalamus associated with nucleus accumbens, dopamine and urological neuroanatomy
19) Confidence 0.10 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1337044 Disease Relevance 0.10 Pain Relevance 0.78
that the D1 receptor-dependent reduction in input resistance
Negative_regulation (reduction) of D1 receptor
20) Confidence 0.09 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2519792 Disease Relevance 0 Pain Relevance 0.52

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