INT70207

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Context Info
Confidence 0.75
First Reported 1996
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 3.99
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LPO) oxidoreductase activity (LPO) extracellular region (LPO)
cellular_component (LPO)
Anatomy Link Frequency
blood 2
cartilage 1
urine 1
LPO (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 111 99.84 Very High Very High Very High
ischemia 1 97.48 Very High Very High Very High
Angina 4 93.92 High High
Inflammatory response 9 87.04 High High
metalloproteinase 15 65.52 Quite High
Pain 3 53.72 Quite High
Inflammation 18 5.00 Very Low Very Low Very Low
Potency 6 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 117 99.84 Very High Very High Very High
Pathologic Processes 3 98.24 Very High Very High Very High
Coronary Artery Disease 3 97.92 Very High Very High Very High
Necrosis 7 96.36 Very High Very High Very High
Cancer 5 96.00 Very High Very High Very High
Cv General 3 Under Development 4 93.92 High High
Toxicity 36 93.76 High High
INFLAMMATION 27 86.64 High High
Aging 9 75.04 Quite High
Disease 6 59.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanism might be correlated to inhibit the calcium overload and reduce LPO production in cardiac cell as well as improve blood supply to myocardial ischemia.
Gene_expression (production) of LPO in blood associated with coronary artery disease and ischemia
1) Confidence 0.75 Published 1996 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Abstract Doc Link 9206240 Disease Relevance 0.55 Pain Relevance 0.36
Tiku et al. reported that chondrocyte-derived LPO products mediate the oxidation of cartilage collagens [14].
Gene_expression (products) of LPO in cartilage
2) Confidence 0.38 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991038 Disease Relevance 0.94 Pain Relevance 0.30
Our results also corroborated the existence of such correlations between As concentration in blood and urine and the activities of these enzymes (negative with GSH, and positive with AST, ALT, AcP, AlkP and LPO).
Neg (negative) Gene_expression (negative) of LPO in urine
3) Confidence 0.35 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1297497 Disease Relevance 0.33 Pain Relevance 0
Furthermore, the relevance of LPO products to OA pathogenesis was manifested by their ability to form adducts.
Gene_expression (products) of LPO associated with osteoarthritis
4) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991038 Disease Relevance 0.84 Pain Relevance 0.33
Generally, free HNE most likely represents one of the main LPO products that can modulate physiological as well as pathological processes, as depicted in a recent, dedicated review [13].
Gene_expression (products) of LPO associated with pathologic processes
5) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991038 Disease Relevance 1.00 Pain Relevance 0.45
Our results also corroborated the existence of such correlations between As concentration in blood and urine and the activities of these enzymes (negative with GSH, and positive with AST, ALT, AcP, AlkP and LPO).
Neg (negative) Gene_expression (negative) of LPO in blood
6) Confidence 0.12 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1297497 Disease Relevance 0.33 Pain Relevance 0

General Comments

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