INT7021

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Context Info
Confidence 0.22
First Reported 1985
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 1.02
Pain Relevance 6.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Npr1) intracellular (Npr1)
Anatomy Link Frequency
neurons 2
endothelium 2
olfactory tubercle 2
Npr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 26 100.00 Very High Very High Very High
agonist 14 100.00 Very High Very High Very High
opioid receptor 13 100.00 Very High Very High Very High
Enkephalin 5 99.60 Very High Very High Very High
Opioid 8 99.12 Very High Very High Very High
Morphine 10 99.04 Very High Very High Very High
Antinociceptive 4 98.98 Very High Very High Very High
cocaine 3 98.70 Very High Very High Very High
opiate 8 98.56 Very High Very High Very High
Nucleus accumbens 6 96.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 9 98.14 Very High Very High Very High
Bordatella Infection 4 77.92 Quite High
Encephalopathy 1 75.00 Quite High
Urological Neuroanatomy 3 72.32 Quite High
Pain 1 31.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibitory effect of dopamine on striatal adenylate cyclase activity is dependent on the presence of GTP, with half-maximal inhibition occurring at 1 microM GTP.
Positive_regulation (dependent) of Negative_regulation (effect) of cyclase associated with dopamine
1) Confidence 0.22 Published 1985 Journal Mol. Pharmacol. Section Abstract Doc Link 2410769 Disease Relevance 0 Pain Relevance 0.64
This persistent decrease in adenylate cyclase was found to occur in a dose-dependent manner and to be mediated through the actions of morphine at opiate receptors, inasmuch as the inhibition was prevented by concomitant in vivo administration of naltrexone, a long-acting opiate receptor antagonist.
Positive_regulation (mediated) of Negative_regulation (decrease) of cyclase associated with antagonist, opiate and morphine
2) Confidence 0.18 Published 1989 Journal Mol. Pharmacol. Section Abstract Doc Link 2498635 Disease Relevance 0.07 Pain Relevance 1.84
Combined inhibition of guanylate cyclase and norepinephrine disposition increased the contractions and abolished the difference between the responses of rings with and without endothelium.
Positive_regulation (increased) of Negative_regulation (inhibition) of guanylate cyclase in endothelium
3) Confidence 0.14 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 3499086 Disease Relevance 0 Pain Relevance 0.12
Therefore, in nucleus accumbens opioids may inhibit DA-sensitive adenylate cyclase through activation of a mu/delta-opioid receptor complex, whereas in olfactory tubercle mu-receptors appear to mediate the inhibition of adenylate cyclase activity.
Spec (appear) Positive_regulation (mediate) of Negative_regulation (inhibition) of cyclase in olfactory tubercle associated with nucleus accumbens, dopamine, opioid receptor and opioid
4) Confidence 0.14 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1337044 Disease Relevance 0 Pain Relevance 0.98
This antinociceptive supersensitivity was accompanied by a significant increase of mu-agonist-induced inhibition of adenylyl cyclase that was resistant to the antagonism by PTX.
Positive_regulation (increase) of Negative_regulation (inhibition) of cyclase associated with agonist and antinociceptive
5) Confidence 0.11 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18384820 Disease Relevance 0.15 Pain Relevance 1.28
The possible involvement of Go in mediating phospholipase C activation and Gi in mediating adenylate cyclase inhibition is discussed.
Positive_regulation (mediating) of Negative_regulation (inhibition) of cyclase
6) Confidence 0.04 Published 1990 Journal Cell. Signal. Section Abstract Doc Link 2174693 Disease Relevance 0.14 Pain Relevance 0.15
In transfected cells expressing mGluR2, AIDA (< or = 1 mM) did not affect the inhibition of forskolin-stimulated adenylate cyclase activity induced by (1S,3R)-ACPD, but at large concentrations, it displayed a modest agonist activity.
Positive_regulation (induced) of Negative_regulation (inhibition) of cyclase associated with agonist
7) Confidence 0.04 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9152378 Disease Relevance 0 Pain Relevance 0.29
Concomitantly with such transductional alteration detected in chronic diabetes, we observed a marked increase of the striatal content of met-enkephalin, which is known to utilize Gi/Go proteins for inhibition of adenylate cyclase.
Positive_regulation (utilize) of Negative_regulation (inhibition) of cyclase associated with diabetes mellitus and enkephalin
8) Confidence 0.04 Published 1989 Journal J. Neurosci. Res. Section Abstract Doc Link 2513414 Disease Relevance 0.65 Pain Relevance 0.35
In support of this, cocaine-mediated increases in activation of dopamine D1 receptors (D1R) results in a desensitization of delta-opioid receptor (DOR) signaling through adenylyl cyclase (AC) in striatal neurons.
Positive_regulation (results) of Negative_regulation (desensitization) of cyclase in neurons associated with dopamine, opioid receptor and cocaine
9) Confidence 0.02 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16517070 Disease Relevance 0 Pain Relevance 0.72

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