INT7022

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Context Info
Confidence 0.05
First Reported 1990
Last Reported 2000
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.26
Pain Relevance 4.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Drd1a, Npr1) intracellular (Drd1a, Npr1) endoplasmic reticulum (Drd1a)
nucleus (Drd1a) signal transducer activity (Drd1a)
Anatomy Link Frequency
neurons 2
hypothalamus 1
brain 1
Drd1a (Rattus norvegicus)
Npr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dopamine receptor 10 100.00 Very High Very High Very High
dopamine 24 99.98 Very High Very High Very High
Enkephalin 12 99.60 Very High Very High Very High
Mu opioid receptor 6 99.48 Very High Very High Very High
agonist 14 99.32 Very High Very High Very High
Accumbens nucleus 12 98.78 Very High Very High Very High
Morphine 6 97.40 Very High Very High Very High
tolerance 1 92.24 High High
addiction 1 91.12 High High
delta opioid receptors 2 90.40 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 4 95.64 Very High Very High Very High
Vibrio Infection 1 95.02 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data indicate that an homogeneous population of mu-opioid receptors coupled as inhibitors to D1 dopamine receptor-stimulated adenylate cyclase is expressed in rat neostriatal neurons in primary culture.
D1 dopamine receptor-stimulated Positive_regulation (stimulated) of cyclase in neurons associated with dopamine receptor and mu opioid receptor
1) Confidence 0.05 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2168934 Disease Relevance 0 Pain Relevance 0.67
D1 dopamine receptor-stimulated adenylate cyclase activity was also slightly reduced (by approximately 20%) by high concentrations of the kappa-agonist U50,488 (EC50 = 0.63 microM).
D1 dopamine receptor-stimulated Positive_regulation (stimulated) of cyclase associated with dopamine receptor and agonist
2) Confidence 0.05 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2168934 Disease Relevance 0 Pain Relevance 0.99
The kappa-agonist, U 50,488, did not affect DA- or D1 receptor-stimulated adenylate cyclase activity in any of the brain regions.
D1 receptor Neg (not) Positive_regulation (stimulated) of cyclase in brain associated with dopamine and agonist
3) Confidence 0.04 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1337044 Disease Relevance 0.07 Pain Relevance 1.12
In slices of rat nucleus accumbens, olfactory tubercle, frontal cortex and mediobasal hypothalamus exposed to dopamine (DA), the activation of DA D1 receptors stimulated cyclic AMP (cAMP) formation whereas, in nucleus accumbens slices only, activation of D2 receptors appeared to inhibit D1 receptor-stimulated adenylate cyclase at the same time.
D1 receptor Positive_regulation (stimulated) of cyclase in hypothalamus associated with dopamine, urological neuroanatomy and accumbens nucleus
4) Confidence 0.04 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1337044 Disease Relevance 0.10 Pain Relevance 0.79
Moreover, the observation that cholera toxin (0.1 nM)-stimulated cyclic AMP production, unlike that induced by forskolin (1 microM), was enhanced in morphine-treated neurons, indicates a causal relationship between the reciprocal changes in G-protein number and the increase of dopamine D1 receptor-stimulated adenylyl cyclase activity.
D1 receptor Positive_regulation (stimulated) of cyclase in neurons associated with dopamine, vibrio infection and morphine
5) Confidence 0.03 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8386668 Disease Relevance 0.10 Pain Relevance 0.75
Unlike U69593 and U50488H, bremazocine is also an antagonist at mu- and delta-opioid receptors, as well as an agonist at a subtype of delta-opioid receptors inhibiting dopamine D1 receptor-stimulated adenylate cyclase.
dopamine D1 receptor Positive_regulation (stimulated) of cyclase
6) Confidence 0.02 Published 2000 Journal Psychopharmacology (Berl.) Section Body Doc Link 10867974 Disease Relevance 0 Pain Relevance 0

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