INT70222

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Context Info
Confidence 0.37
First Reported 1997
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 11.73
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (POMT1) endoplasmic reticulum (POMT1) extracellular matrix organization (POMT1)
carbohydrate metabolic process (POMT1)
Anatomy Link Frequency
plasma 2
body 2
muscle 1
medial 1
brain 1
POMT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 109 100.00 Very High Very High Very High
imagery 98 99.84 Very High Very High Very High
cytokine 120 99.20 Very High Very High Very High
tolerance 114 97.40 Very High Very High Very High
Inflammatory marker 14 96.36 Very High Very High Very High
Inflammation 31 84.52 Quite High
depression 5 73.40 Quite High
backache 7 57.88 Quite High
Arthritis 7 57.28 Quite High
Angina 2 33.68 Quite Low
Disease Link Frequency Relevance Heat
Pain 109 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 89 100.00 Very High Very High Very High
Metastasis 27 99.56 Very High Very High Very High
Reprotox - General 1 56 99.40 Very High Very High Very High
Diabetes Mellitus 301 99.32 Very High Very High Very High
Impaired Glucose Tolerance 203 97.72 Very High Very High Very High
Radiation Pneumonitis 112 97.60 Very High Very High Very High
Frailty 79 97.20 Very High Very High Very High
Toxicity 34 96.72 Very High Very High Very High
INFLAMMATION 45 96.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additional assessments were done over the course of RT and for 4 months after the completion of RT.
RT Binding (completion) of
1) Confidence 0.37 Published 2009 Journal Support Care Cancer Section Body Doc Link PMC2762051 Disease Relevance 0.52 Pain Relevance 0.06
MIV-150 is a novel, potent NNRTI, which binds tightly to the HIV reverse transcriptase (RT), and has strong antiviral (IC50 of <1 nM) and potentially virucidal (IC50 of 400 nM) activity against R5 and X4 viruses [13], [20], [21].
RT Binding (binds) of associated with acquired immune deficiency syndrome or hiv infection
2) Confidence 0.35 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016413 Disease Relevance 0.71 Pain Relevance 0
160) who underwent RT for breast or prostate cancer.
RT Binding (underwent) of associated with reprotox - general 1
3) Confidence 0.32 Published 2009 Journal Support Care Cancer Section Abstract Doc Link PMC2762051 Disease Relevance 0.24 Pain Relevance 0.07
The mean number of symptoms per patient at the middle, end, and 1 month after the completion of RT was 6.5 (SD?
RT Binding (completion) of
4) Confidence 0.32 Published 2009 Journal Support Care Cancer Section Body Doc Link PMC2762051 Disease Relevance 0.55 Pain Relevance 0.09
In a study of patients who underwent RT for brain metastasis [7], three symptom clusters were identified at five different time points during RT.
RT Binding (underwent) of in brain associated with metastasis
5) Confidence 0.32 Published 2009 Journal Support Care Cancer Section Body Doc Link PMC2762051 Disease Relevance 0.36 Pain Relevance 0
The stability of these three symptoms is consistent with two previous longitudinal RT studies [7, 24] and suggests that these symptoms require systematic assessment and management in patients who undergo RT.
RT Binding (undergo) of
6) Confidence 0.32 Published 2009 Journal Support Care Cancer Section Body Doc Link PMC2762051 Disease Relevance 0.76 Pain Relevance 0.17
They interact at a specific site in the pain domain of the p66 subunit of RT.
RT Binding (interact) of associated with pain
7) Confidence 0.21 Published 1997 Journal Leukemia Section Abstract Doc Link 9209308 Disease Relevance 0.56 Pain Relevance 0.10
Since Y181C and L1001 are the most commonly observed resistance-engendering mutations, RT enzymatic analysis was correlated with molecular modeling to glean information on the structural interactions between these NNRTIs and RT.
RT Binding (interactions) of
8) Confidence 0.18 Published 1997 Journal Leukemia Section Abstract Doc Link 9209308 Disease Relevance 0.47 Pain Relevance 0.08
Oxathlin carboxanilide analogs (UC) and alpha APA, compounds recognized as nonnucleoside reverse transcriptase (RT) inhibitors (NNRTI), were evaluated for activity against the human immunodeficiency virus (HIV-1) and drug-resistant variants.
RT Binding (recognized) of associated with acquired immune deficiency syndrome or hiv infection
9) Confidence 0.18 Published 1997 Journal Leukemia Section Abstract Doc Link 9209308 Disease Relevance 0.50 Pain Relevance 0.08
Thus, there is an increasing influence of biomechanical constraints on RT with increasing number of axes of rotation, which exemplifies increased engagement in MI (Parsons 1994; Lust et al. 2006).
RT Binding (engagement) of associated with imagery
10) Confidence 0.07 Published 2010 Journal Exp Brain Res Section Body Doc Link PMC2871105 Disease Relevance 0.06 Pain Relevance 0.12
As a result, RT differences between lateral- and medial-rotated stimuli can be used as excellent measure to test for engagement in MI.
RT Binding (engagement) of in medial associated with imagery
11) Confidence 0.07 Published 2010 Journal Exp Brain Res Section Body Doc Link PMC2871105 Disease Relevance 0.39 Pain Relevance 0.26
Figure 2 shows examples of RT-PCR analyses of matched tumorous and nontumorous tissues from five patients for mRNA expression of 5?
RT Binding (examples) of
12) Confidence 0.05 Published 2004 Journal BMC Cancer Section Body Doc Link PMC459223 Disease Relevance 0.27 Pain Relevance 0
1 end-RT/TGF-?
RT Binding (end) of
13) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2483418 Disease Relevance 0.83 Pain Relevance 0
g/kg) is inadequate for older adults who engage in RT [142].
RT Binding (engage) of
14) Confidence 0.03 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3010636 Disease Relevance 0.49 Pain Relevance 0.10
Cytokine plasma levels before, during and after completion of RT
RT Binding (completion) of in plasma associated with cytokine
15) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2483418 Disease Relevance 1.04 Pain Relevance 0.17
Though older adults demonstrate reduced overall muscle protein synthesis (MPS) relative to younger adults after a bout of resistance training [104], clinical trials investigating RT interventions among older adults have shown improvements in insulin-resistance and sarcopenia, by increasing lean body mass [19–31].
RT Binding (interventions) of in body associated with frailty
16) Confidence 0.02 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3010636 Disease Relevance 0.45 Pain Relevance 0.09
Older adults who engage in RT may see benefits with respect to improvements in body composition, body fat distribution, inflammatory markers, and blood glucose homeostasis.
RT Binding (engage) of in body associated with inflammatory marker
17) Confidence 0.02 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3010636 Disease Relevance 0.77 Pain Relevance 0.14
With the possibility that high protein diets can be beneficial to those with impairments in glucose metabolism as well as older adults engaging in RT, the synergistic effect of RT and high protein diets on glucose tolerance warrants further investigation.
RT Binding (engaging) of associated with tolerance and impaired glucose tolerance
18) Confidence 0.02 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3010636 Disease Relevance 0.64 Pain Relevance 0.12
According to the ACSM, older adults should engage in RT at least twice per week.
RT Binding (engage) of
19) Confidence 0.02 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3010636 Disease Relevance 0.70 Pain Relevance 0
Major health organizations have recognized the benefits of RT.
RT Binding (recognized) of
20) Confidence 0.02 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3010636 Disease Relevance 0.39 Pain Relevance 0.04

General Comments

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