INT70226

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Context Info
Confidence 0.24
First Reported 1997
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 4.50
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TAC1) extracellular region (TAC1) Golgi apparatus (B3GAT1)
plasma membrane (TAC1) carbohydrate metabolic process (B3GAT1) cell-cell signaling (TAC1)
Anatomy Link Frequency
brain 2
vasculature 1
brain stem 1
TAC1 (Homo sapiens)
B3GAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 99 100.00 Very High Very High Very High
substance P 14 100.00 Very High Very High Very High
Migraine 1 98.90 Very High Very High Very High
dexamethasone 116 93.60 High High
Antiemetics 22 90.92 High High
agonist 2 89.64 High High
Serotonin 44 88.56 High High
Calcitonin gene-related peptide 1 75.00 Quite High
corticosteroid 24 34.52 Quite Low
headache 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Vomiting 604 99.66 Very High Very High Very High
Headache 15 98.90 Very High Very High Very High
Increased Venous Pressure Under Development 4 97.20 Very High Very High Very High
Cancer 10 93.52 High High
Cerebral Edema 1 67.60 Quite High
Breast Cancer 6 55.44 Quite High
Clinical Trials And Case Reports 4 54.80 Quite High
Fatigue 12 5.00 Very Low Very Low Very Low
Constipation 12 5.00 Very Low Very Low Very Low
Appetite Loss 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Aprepitant is thought to prevent emesis by blocking the binding of substance P to NK1 receptors in the brain (Aguilar et al. 2005; Kris et al. 2005; Viale 2005).
substance P Binding (binding) of NK1 in brain associated with vomiting and substance p
1) Confidence 0.24 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012554 Disease Relevance 1.03 Pain Relevance 0.14
Aprepitant is believed to prevent emesis by blocking the binding of substance P to NK1 receptors in the brain.
substance P Binding (binding) of NK1 in brain associated with vomiting and substance p
2) Confidence 0.24 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012554 Disease Relevance 0.92 Pain Relevance 0.18
In humans, vasodilation within the meningeal vasculature has been implicated in the pathogenesis of migraine, the present experiments indicate that substance P or neurokinin A (both acting through NK1 receptors) or CGRP may be responsible.
neurokinin Binding (acting) of NK1 in vasculature associated with migraine, increased venous pressure under development and substance p
3) Confidence 0.07 Published 1997 Journal Cephalalgia Section Abstract Doc Link 9209773 Disease Relevance 0.35 Pain Relevance 0.42
Substance P, a tachykinin, binds to NK1 receptors in the brain stem which send messages to the vomiting center and induce vomiting.
tachykinin Binding (binds) of NK1 in brain stem associated with vomiting and substance p
4) Confidence 0.01 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504061 Disease Relevance 1.38 Pain Relevance 0.31
Its antiemetic properties are attributable to aprepitant, which is a selective neurokinin 1 (NK1) receptor antagonist with low affinity for NK2 and NK3 receptors (Watson et al 1998).
NK2 Binding (affinity) of NK1 associated with antagonist and vomiting
5) Confidence 0.01 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504061 Disease Relevance 0.82 Pain Relevance 0.20

General Comments

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